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Cellular and molecular mediators of intestinal fibrosis

Permanent lenke
https://hdl.handle.net/10037/25352
DOI
https://doi.org/10.1016/j.crohns.2014.09.008
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article.pdf (937.6Kb)
Publisert versjon (PDF)
Dato
2015-11-02
Type
Journal article
Tidsskriftartikkel
Peer reviewed

Forfatter
Lawrance, Ian; Rogler, Gerhard; Bamias, Giorgos; Breynaert, Chrstine; Florholmen, Jon; Pellino, Gianluca; Reif, Shimon; Speca, Silvia; Latella, Giovanni
Sammendrag
Intestinal fibrosis is a major complication of the inflammatory bowel diseases (IBD) and although inflammation is necessary for its development, it would appear that it plays a minor role in its progression as anti-inflammatory treatments in IBD do not prevent fibrosis once it has started. The processes that regulate fibrosis would thus appear to be distinct from those regulating inflammation and, therefore, a detailed understanding of these pathways is vital to the development of antifibrogenic strategies. There have been several recent reviews exploring what is known, and what remains unknown, about the development of intestinal fibrosis. This review is designed to add to this literature but with a focus on the cellular components that are involved in the development of fibrogenesis and the major molecular mediators that impact on these cells. The aim is to heighten the understanding of the factors involved in intestinal fibrogenesis so that detailed research can be encouraged in order to advance the processes that could lead to effective treatments.
Forlag
Oxford University Press
Sitering
Ian C Lawrance, Gerhard Rogler, Giorgos Bamias, Christine Breynaert, Jon Florholmen, Gianluca Pellino, Shimon Reif, Silvia Speca, Giovanni Latella, Cellular and Molecular Mediators of Intestinal Fibrosis, Journal of Crohn's and Colitis, Volume 11, Issue 12, December 2017, Pages 1491–1503
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Samlinger
  • Artikler, rapporter og annet (klinisk medisin) [1974]
Copyright 2015 Oxford University Press

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