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dc.contributor.authorLinkas, Jonas
dc.contributor.authorAhmed, Luai A.
dc.contributor.authorCsifcsak, Gabor
dc.contributor.authorEmaus, Nina
dc.contributor.authorFurberg, Anne-Sofie
dc.contributor.authorGrimnes, Guri
dc.contributor.authorPettersen, Gunn
dc.contributor.authorRognmo, Kamilla
dc.contributor.authorChristoffersen, Tore
dc.date.accessioned2022-08-23T09:09:27Z
dc.date.available2022-08-23T09:09:27Z
dc.date.issued2022-03-11
dc.description.abstractObjective: The scarcity of research on associations between inflammatory markers and symptoms of depression and anxiety during adolescence has yielded inconsistent results. Further, not all studies have controlled for potential confounders. We explored the associations between baseline inflammatory markers and psychological distress including moderators at follow-up in a Norwegian adolescent population sample.<p> <p>Methods: Data was derived from 373 girls and 294 boys aged 15–18 years at baseline, in the Fit Futures Study, a large-scale 2-year follow-up study on adolescent health. Baseline data was gathered from 2010 to 2011 and follow-up data from 2012 to 2013. Psychological distress was measured with Hopkins Symptom Checklist (HSCL-10). Serum levels of the following inflammatory markers were measured: C-reactive protein (CRP), Interleukin 6 (IL-6), Transforming growth factor alpha (TGF-α), Tumor necrosis factor alpha variant 1 (TRANCE), and variant 2 (TWEAK). Independent associations between baseline inflammatory markers and HSCL-10 at follow-up were explored by linear regressions, in sex-stratified analyses.<p> <p>Results: In girls, analyses showed positive associations between all inflammatory markers and HSCL-10, except for TRANCE. However, all associations were non-significant in crude as well as in adjusted analyses. In boys, CRP (p = 0.03) and TGF-α (p < 0.01) showed significant associations with HSCL-10, that remained significant after adjustment. Additionally, moderators were found. In boys, CRP was associated with HSCL-10 in those with high body fat and those being physical inactive, and the association between TWEAK and HSCL-10 was dependent upon sleep duration.<p> <p>Conclusion: There were significant prospective associations between CRP, TFG-α, and HSCL-10 in boys aged 15–18 years at baseline.en_US
dc.identifier.citationLinkas J, Ahmed L, Csifcsak G, Emaus N, Furberg A-S, Grimnes G, Pettersen, Rognmo K, Christoffersen T. C-Reactive Protein and TGF-α Predict Psychological Distress at Two Years of Follow-Up in Healthy Adolescent Boys: The Fit Futures Study. Frontiers in Psychology. 2022;13:1-12en_US
dc.identifier.cristinIDFRIDAID 2009194
dc.identifier.doi10.3389/fpsyg.2022.823420
dc.identifier.issn1664-1078
dc.identifier.urihttps://hdl.handle.net/10037/26357
dc.language.isoengen_US
dc.publisherFrontiers Mediaen_US
dc.relation.ispartofLinkas, J. (2022). Inflammation and Sleep as Risk Factors for Psychological Distress During Adolescence. The influence of low-grade inflammation and sleep duration on psychological distress in girls and boys aged 15-18 years. The Fit Futures study. (Doctoral thesis). <a href=https://hdl.handle.net/10037/27917 >https://hdl.handle.net/10037/27917</a>.
dc.relation.journalFrontiers in Psychology
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.titleC-Reactive Protein and TGF-α Predict Psychological Distress at Two Years of Follow-Up in Healthy Adolescent Boys: The Fit Futures Studyen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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