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dc.contributor.authorPetrovic, Dusan
dc.contributor.authorBodinier, Barbara
dc.contributor.authorDagnino, Sonia
dc.contributor.authorWhitaker, Matthew
dc.contributor.authorKarimi, Maryam
dc.contributor.authorCampanella, Gianluca
dc.contributor.authorNøst, Therese Haugdahl
dc.contributor.authorPolidoro, Silvia
dc.contributor.authorPalli, Domenico
dc.contributor.authorKrogh, Vittorio
dc.contributor.authorTumino, Rosario
dc.contributor.authorSacerdote, Carlotta
dc.contributor.authorPanico, Salvatore
dc.contributor.authorLund, Eiliv
dc.contributor.authorDugué, Pierre-Antoine
dc.contributor.authorGiles, Graham G
dc.contributor.authorSeveri, Gianluca
dc.contributor.authorSouthey, Melissa
dc.contributor.authorVineis, Paolo
dc.contributor.authorStringhini, Silvia
dc.contributor.authorBochud, Murielle
dc.contributor.authorSandanger, Torkjel M
dc.contributor.authorVermeulen, Roel CH
dc.contributor.authorGuida, Florence
dc.contributor.authorChadeau-Hyam, Marc
dc.date.accessioned2022-08-29T06:17:25Z
dc.date.available2022-08-29T06:17:25Z
dc.date.issued2022-05-20
dc.description.abstractSmoking-related epigenetic changes have been linked to lung cancer, but the contribution of epigenetic alterations unrelated to smoking remains unclear. We sought for a sparse set of CpG sites predicting lung cancer and explored the role of smoking in these associations. We analysed CpGs in relation to lung cancer in participants from two nested case–control studies, using (LASSO)-penalised regression. We accounted for the efects of smoking using known smoking-related CpGs, and through conditional-independence network. We identifed 29 CpGs (8 smoking-related, 21 smoking-unrelated) associated with lung cancer. Models additionally adjusted for Comprehensive Smoking Index-(CSI) selected 1 smoking-related and 49 smokingunrelated CpGs. Selected CpGs yielded excellent discriminatory performances, outperforming information provided by CSI only. Of the 8 selected smoking-related CpGs, two captured lung cancer-relevant efects of smoking that were missed by CSI. Further, the 50 CpGs identifed in the CSI-adjusted model complementarily explained lung cancer risk. These markers may provide further insight into lung cancer carcinogenesis and help improving early identifcation of high-risk patients.en_US
dc.identifier.citationPetrovic, Bodinier, Dagnino, Whitaker, Karimi, Campanella, Nøst, Polidoro, Palli, Krogh, Tumino, Sacerdote, Panico, Lund, Dugué, Giles, Severi, Southey, Vineis, Stringhini, Bochud, Sandanger, Vermeulen, Guida, Chadeau-Hyam. Epigenetic mechanisms of lung carcinogenesis involve differentially methylated CpG sites beyond those associated with smoking. European Journal of Epidemiology (EJE). 2022en_US
dc.identifier.cristinIDFRIDAID 2028199
dc.identifier.doi10.1007/s10654-022-00877-2
dc.identifier.issn0393-2990
dc.identifier.issn1573-7284
dc.identifier.urihttps://hdl.handle.net/10037/26449
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.relation.journalEuropean Journal of Epidemiology (EJE)
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7-IDEAS-ERC/232997/EU/TRANSCRIPTOMICS IN CANCER EPIDEMIOLOGY/TICE/en_US
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/SOCIETAL CHALLENGES/874627/EU/EXposome Powered tools for healthy living in urbAN SEttings/EXPANSE/en_US
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/EXCELLENT SCIENCE/708392/EU/Identifying biomarkers of Exposure leading to Lung Cancer with Adductomics/EXACT/en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.titleEpigenetic mechanisms of lung carcinogenesis involve differentially methylated CpG sites beyond those associated with smokingen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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