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Diversity and Selection of Surface Marine Microbiomes in the Atlantic-Influenced Arctic

Permanent link
https://hdl.handle.net/10037/26466
DOI
https://doi.org/10.3389/fmicb.2022.892634
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Date
2022-07-14
Type
Journal article
Tidsskriftartikkel
Peer reviewed

Author
Aalto, Nerea Johanna; Schweitzer, Hannah D.; Krsmanovic, Stina; Campbell, Karley; Bernstein, Hans Christopher
Abstract
Serglycin is a proteoglycan highly expressed by immune cells, in which its functions are linked to storage, secretion, transport, and protection of chemokines, proteases, histamine, growth factors, and other bioactive molecules. In recent years, it has been demonstrated that serglycin is also expressed by several other cell types, such as endothelial cells, muscle cells, and multiple types of cancer cells. Here, we show that serglycin expression is upregulated in transforming growth factor beta (TGF-b) induced epithelial-mesenchymal transition (EMT). Functional studies provide evidence that serglycin plays an important role in the regulation of the transition between the epithelial and mesenchymal phenotypes, and it is a significant EMT marker gene. We further find that serglycin is more expressed by breast cancer cell lines with a mesenchymal phenotype as well as the basal-like subtype of breast cancers. By examining immune staining and single cell sequencing data of breast cancer tissue, we show that serglycin is highly expressed by infiltrating immune cells in breast tumor tissue.
Is part of
Aalto, N.J. (2022). Atmospheric CO2 drawdown, community dynamics and selection of surface microbiomes in marine cold-water ecosystems. (Doctoral thesis). https://hdl.handle.net/10037/26900.
Publisher
Frontiers Media
Citation
Aalto, Schweitzer HD, Krsmanovic S, Campbell KL, Bernstein HC. Diversity and Selection of Surface Marine Microbiomes in the Atlantic-Influenced Arctic. Frontiers in Microbiology. 2022;13
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