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Neonatal sepsis: a systematic review of core outcomes from randomised clinical trials

Permanent lenke
https://hdl.handle.net/10037/26481
DOI
https://doi.org/10.1038/s41390-021-01883-y
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Åpne
article.pdf (1.144Mb)
Publisert versjon (PDF)
Dato
2022-01-07
Type
Journal article
Tidsskriftartikkel
Peer reviewed

Forfatter
Henry, Cían J.; Semova, Gergana; Barnes, Ellen; Cotter, Isabel; Devers, Tara; Rafaee, Aisyah; Slavescu, Andreea; Cathain, Niamh O.; McCollum, Danielle; Roche, Edna; Mockler, David; Allen, John; Meehan, Judith; Klingenberg, Claus Andreas; Latour, Jos M.; van den Hoogen, Agnes; Strunk, Tobias; Giannoni, Eric; Schlapbach, Luregn J.; Degtyareva, Marina; Plötz, Frans B.; de Boode, Willem P.; Naver, Lars; Wynn, James L.; Küster, Helmut; Janota, Jan; Keij, Fleur M.; Reiss, Irwin K. M.; Bliss, Joseph M.; Polin, Richard; Koenig, Joyce M.; Turner, Mark A.; Gale, Christopher; Molloy, Eleanor J.
Sammendrag
BACKGROUND: The lack of a consensus definition of neonatal sepsis and a core outcome set (COS) proves a substantial impediment to research that influences policy and practice relevant to key stakeholders, patients and parents.

METHODS: A systematic review of the literature was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. In the included studies, the described outcomes were extracted in accordance with the provisions of the Core Outcome Measures in Effectiveness Trials (COMET) handbook and registered.

RESULTS: Among 884 abstracts identified, 90 randomised controlled trials (RCTs) were included in this review. Only 30 manuscripts explicitly stated the primary and/or secondary outcomes. A total of 88 distinct outcomes were recorded across all 90 studies included. These were then assigned to seven different domains in line with the taxonomy for classification proposed by the COMET initiative. The most frequently reported outcome was survival with 74% (n = 67) of the studies reporting an outcome within this domain.

CONCLUSIONS: This systematic review constitutes one of the initial phases in the protocol for developing a COS in neonatal sepsis. The paucity of standardised outcome reporting in neonatal sepsis hinders comparison and synthesis of data. The final phase will involve a Delphi Survey to generate a COS in neonatal sepsis by consensus recommendation.

Forlag
Springer Nature
Sitering
Henry, Semova, Barnes, Cotter, Devers, Rafaee, Slavescu, Cathain, McCollum, Roche, Mockler, Allen, Meehan, Klingenberg, Latour, van den Hoogen, Strunk, Giannoni, Schlapbach, Degtyareva, Plötz, de Boode, Naver, Wynn, Küster, Janota, Keij, Reiss, Bliss, Polin, Koenig, Turner, Gale, Molloy. Neonatal sepsis: a systematic review of core outcomes from randomised clinical trials. Pediatric Research. 2022;91:735-742
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  • Artikler, rapporter og annet (klinisk medisin) [1974]
Copyright 2022 The Author(s)

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