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dc.contributor.authorGjerstad, Ann Christin
dc.contributor.authorSkrunes, Rannveig
dc.contributor.authorTøndel, Camilla
dc.contributor.authorÅsberg, Anders
dc.contributor.authorLeh, Sabine
dc.contributor.authorKlingenberg, Claus Andreas
dc.contributor.authorDøllner, Henrik
dc.contributor.authorHammarström, Clara Louise
dc.contributor.authorBjerre, Anna Kristina
dc.description.abstractBackground There is scarce information on biopsy-verifed kidney disease in childhood and its progression to chronic kidney disease stage 5 (CKD 5). This study aims to review biopsy fndings in children, and to investigate risk of kidney replacement therapy (KRT).<p> <p>Methods We conducted a retrospective long-term follow-up study of children included in the Norwegian Kidney Biopsy Registry (NKBR) and in the Norwegian Renal Registry (NRR) from 1988 to 2021. <p>Results In total, 575 children with a median (interquartile range, IQR) age of 10.7 (6.1 to 14.1) years were included, and median follow-up time (IQR) after kidney biopsy was 14.3 (range 8.9 to 21.6) years. The most common biopsy diagnoses were minimal change disease (MCD; n=92), IgA vasculitis nephritis (IgAVN; n=76), IgA nephropathy (n=63), and focal and segmental glomerulosclerosis (FSGS; n=47). In total, 118 (20.5%) of the biopsied children reached CKD 5, median (IQR) time to KRT 2.3 years (7 months to 8.4 years). Most frequently, nephronophthisis (NPHP; n=16), FSGS (n=30), IgA nephropathy (n=9), and membranoproliferative glomerulonephritis (MPGN; n=9) led to KRT. <p>Conclusions The risk of KRT after a kidney biopsy diagnosis is highly dependent on the diagnosis. None of the children with MCD commenced KRT, while 63.8% with FSGS and 100% with NPHP reached KRT. Combining data from kidney biopsy registries with registries on KRT allows for detailed information concerning the risk for later CKD 5 after biopsyverifed kidney disease in childhood.en_US
dc.identifier.citationGjerstad AC, Skrunes R, Tøndel C, Åsberg A, Leh S, Klingenberg C, Døllner H, Hammarström CL, Bjerre AK. Kidney biopsy diagnosis in childhood in the Norwegian Kidney Biopsy Registry and the long-term risk of kidney replacement therapy: a 25-year follow-up. Pediatric nephrology (Berlin, West). 2022:1-8en_US
dc.identifier.cristinIDFRIDAID 2045133
dc.relation.journalPediatric nephrology (Berlin, West)
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleKidney biopsy diagnosis in childhood in the Norwegian Kidney Biopsy Registry and the long-term risk of kidney replacement therapy: a 25-year follow-upen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US

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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's license is described as Attribution 4.0 International (CC BY 4.0)