Show simple item record

dc.contributor.authorAndreassen, Runa Marie
dc.contributor.authorKronborg, Jens
dc.contributor.authorSchirmer, Henrik
dc.contributor.authorMathiesen, Ellisiv B.
dc.contributor.authorMelsom, Toralf
dc.contributor.authorEriksen, Bjørn Odvar
dc.contributor.authorJenssen, Trond Geir
dc.contributor.authorSolbu, Marit Dahl
dc.description.abstractObjectives. Urinary albumin excretion is a risk marker for cardiovascular disease (CVD). Studies suggest that urinary orosomucoid may be a more sensitive marker of general endothelial dysfunction than albuminuria. The aim of this population-based cross-sectional study was to examine the associations between urinary orosomucoid to creatinine ratio (UOCR), urinary albumin to creatinine ratio (UACR) and subclinical CVD. Design. From the Tromsø Study (2007/2008), we included all men and women who had measurements of urinary orosomucoid (n ¼ 7181). Among these, 6963 were examined with ultrasound of the right carotid artery and 2245 with echocardiography. We assessed the associations between urinary markers and subclinical CVD measured as intima media thickness of the carotid artery, presence and area of carotid plaque and diastolic dysfunction (DD). UOCR and UACR were dichotomized as upper quartile versus the three lowest. Results. High UOCR, adjusted for UACR, age, cardiovascular risk factors and kidney function, was associated with presence of DD in men (OR: 3.18, 95% CI [1.27, 7.95], p ¼ .013), and presence of plaque (OR: 1.20, 95% CI [1.01, 1.44], p ¼ .038) and intima media thickness in women (OR: 1.34, 95% CI [1.09, 1.65], p ¼ .005). Analyses showed no significant interaction between sex and UOCR for any endpoints. UACR was not significantly associated with DD, but the associations with intima media thickness and plaque were of magnitudes comparable to those observed for UOCR. Conclusions. UOCR was positively associated with subclinical CVD. We need prospective studies to confirm whether UOCR is a clinically useful biomarker and to study possible sex differences.en_US
dc.identifier.citationAndreassen, Kronborg, Schirmer, Mathiesen, Melsom, Eriksen, Jenssen, Solbu. Urinary orosomucoid is associated with diastolic dysfunction and carotid arteriopathy in the general population. Cross-sectional data from the Tromsø study. Scandinavian Cardiovascular Journal. 2022;56(1):148-156en_US
dc.identifier.cristinIDFRIDAID 2046747
dc.publisherTaylor & Francisen_US
dc.relation.journalScandinavian Cardiovascular Journal
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleUrinary orosomucoid is associated with diastolic dysfunction and carotid arteriopathy in the general population. Cross-sectional data from the Tromsø studyen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US

File(s) in this item


This item appears in the following collection(s)

Show simple item record

Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's license is described as Attribution 4.0 International (CC BY 4.0)