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dc.contributor.authorde Freitas Almeida, Gabriel Magno
dc.contributor.authorHoikkala, Ville
dc.contributor.authorRavantti, Janne
dc.contributor.authorRantanen, Noora
dc.contributor.authorSundberg, Lotta-Riina
dc.date.accessioned2022-10-31T11:32:09Z
dc.date.available2022-10-31T11:32:09Z
dc.date.issued2022-06-25
dc.description.abstractMucin induces CRISPR-Cas defense in an opportunistic pathogenen_US
dc.description.abstractParasitism by bacteriophages has led to the evolution of a variety of defense mechanisms in their host bacteria. However, it is unclear what factors lead to specific defenses being deployed upon phage infection. To explore this question, we co-evolved the bacterial fish pathogen <i>Flavobacterium columnare</i> and its virulent phage V156 in presence and absence of a eukaryotic host signal (mucin) for sixteen weeks. The presence of mucin leads to a dramatic increase in CRISPR spacer acquisition, especially in low nutrient conditions where over 60% of colonies obtain at least one new spacer. Additionally, we show that the presence of a competitor bacterium further increases CRISPR spacer acquisition in <i>F. columnare</i>. These results suggest that ecological factors are important in determining defense strategies against phages, and that the phage-bacterium interactions on mucosal surfaces may select for the diversification of bacterial immune systems.en_US
dc.identifier.citationde Freitas Almeida, Hoikkala, Ravantti, Rantanen, Sundberg. Mucin induces CRISPR-Cas defense in an opportunistic pathogen. Nature Communications. 2022;13(1)en_US
dc.identifier.cristinIDFRIDAID 2055248
dc.identifier.doi10.1038/s41467-022-31330-3
dc.identifier.issn2041-1723
dc.identifier.urihttps://hdl.handle.net/10037/27189
dc.language.isoengen_US
dc.publisherNature Researchen_US
dc.relation.journalNature Communications
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleMucin induces CRISPR-Cas defense in an opportunistic pathogenen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Med mindre det står noe annet, er denne innførselens lisens beskrevet som Attribution 4.0 International (CC BY 4.0)