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dc.contributor.authorEltoft, Agnethe
dc.contributor.authorWilsgaard, Tom
dc.contributor.authorRoaldsen, Melinda Berg
dc.contributor.authorSøyland, Mary-Helen
dc.contributor.authorLundström, Erik
dc.contributor.authorPetersson, Jesper
dc.contributor.authorIndredavik, Bent
dc.contributor.authorPutaala, Jukka
dc.contributor.authorChristensen, Hanne
dc.contributor.authorKõrv, Janika
dc.contributor.authorJatužis, Dalius
dc.contributor.authorEngelter, Stefan T.
dc.contributor.authorDe Marchis, Gian Marco
dc.contributor.authorWerring, David J.
dc.contributor.authorRobinson, Thompson
dc.contributor.authorTveiten, Arnstein
dc.contributor.authorMathiesen, Ellisiv B.
dc.date.accessioned2022-11-10T09:24:19Z
dc.date.available2022-11-10T09:24:19Z
dc.date.issued2022-05-19
dc.description.abstractBackground: Patients with wake-up ischemic stroke are frequently excluded from thrombolytic treatment due to unknown symptom onset time and limited availability of advanced imaging modalities. The Tenecteplase in Wake-up Ischaemic Stroke Trial (TWIST) is a randomized controlled trial of intravenous tenecteplase 0.25 mg/kg and standard care versus standard care alone (no thrombolysis) in patients who wake up with acute ischemic stroke and can be treated within 4.5 h of wakening based on non-contrast CT findings.<p> <p>Objective: To publish the detailed statistical analysis plan for TWIST prior to unblinding. Methods: The TWIST statistical analysis plan is consistent with the Consolidating Standard of Reporting Trials (CON‑ SORT) statement and provides clear and open reporting. <p>Discussion: Publication of the statistical analysis plan serves to reduce potential trial reporting bias and clearly out‑ lines the pre-specifed analyses. <p>Trial registration: ClinicalTrials.gov NCT03181360. EudraCT Number 2014-000096-80. WHO ICRTP registry number ISRCTN10601890.en_US
dc.identifier.citationEltoft, Wilsgaard, Roaldsen, Søyland, Lundström, Petersson, Indredavik, Putaala, Christensen, Kõrv, Jatužis, Engelter, De Marchis, Werring, Robinson, Tveiten, Mathiesen. Statistical analysis plan for the randomized controlled trial Tenecteplase in Wake-up Ischaemic Stroke Trial (TWIST). Trials. 2022;23(1)en_US
dc.identifier.cristinIDFRIDAID 2045816
dc.identifier.doi10.1186/s13063-022-06301-0
dc.identifier.issn1745-6215
dc.identifier.urihttps://hdl.handle.net/10037/27320
dc.language.isoengen_US
dc.publisherBMCen_US
dc.relation.journalTrials
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleStatistical analysis plan for the randomized controlled trial Tenecteplase in Wake-up Ischaemic Stroke Trial (TWIST)en_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Med mindre det står noe annet, er denne innførselens lisens beskrevet som Attribution 4.0 International (CC BY 4.0)