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dc.contributor.advisorSkalko-Basnet, Natasa
dc.contributor.advisorTho, Ingunn
dc.contributor.authorHussain, Haider
dc.date.accessioned2010-10-18T10:49:32Z
dc.date.available2010-10-18T10:49:32Z
dc.date.issued2010-06-16
dc.description.abstractCurcumin (I), demethoxy curcumin (II) and bisdemethoxy curcumin (III) are commonly called curcuminoids, and derived products from the spice, turmeric. It has reported numerous of therapeutic activities including, anti-inflammatory, and anticancer properties. The aim of the current study was to develop a formulation which can overcome the limitation of curcumin being so poorly soluble in aqueous medium. Our approach has been directed toward investigating the potential of using liposomal formulations as carrier system for curcumin destined for treatment of vaginal inflammation. Curcumin containing liposomes were prepared using soya phosphatidylcholine by the modified film method. Moreover, we added cholesterol in various molar ratios to affect the vesicle membrane rigidity. Curcumin entrapped in the liposomes was quantified and the entrapment efficiency was found to be reaching up to 100%. The size and size distribution of liposomes were determined on photon correlation spectroscopy. The results showed an increase in size of liposomes containing curcumin in comparison with empty liposomes. The accelerated stability testing was used to predict the stability of the formulations. The test revealed changes in the characteristics of the liposomes. The free radical scavenging activity (DPPH) assay of curcumin and Curcuma extract, as well as isolated pure curcumin I, revealed that curcuminoids mixtures have stronger activity.en
dc.format.extent1044202 bytes
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/10037/2751
dc.identifier.urnURN:NBN:no-uit_munin_2496
dc.language.isoengen
dc.publisherUniversitetet i Tromsøen
dc.publisherUniversity of Tromsøen
dc.rights.accessRightsopenAccess
dc.rights.holderCopyright 2010 The Author(s)
dc.subject.courseIDFAR-3901nor
dc.subjectVDP::Medisinske fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Biofarmasi: 736en
dc.subjectDrug transport and deliveryen
dc.subjectPharmacyen
dc.titleDevelopment of liposomal curcumin for vaginal drug deliveryen
dc.typeMaster thesisen
dc.typeMastergradsoppgaveen


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