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dc.contributor.authorLekva, Tove
dc.contributor.authorUeland, Thor
dc.contributor.authorHalvorsen, Bente
dc.contributor.authorMurphy, Sarah Louise Mikalsen
dc.contributor.authorDyrhol-Riise, Anne Ma
dc.contributor.authorTveita, Anders Aune
dc.contributor.authorFinbråten, Ane-Kristine
dc.contributor.authorMathiessen, Alexander
dc.contributor.authorMuller, Karl Erik
dc.contributor.authorAaløkken, Trond Mogens
dc.contributor.authorSkjønsberg, Ole Henning
dc.contributor.authorLerum, Tøri Vigeland
dc.contributor.authorAukrust, Pål
dc.contributor.authorDahl, Tuva Børresdatter
dc.date.accessioned2022-11-30T08:24:45Z
dc.date.available2022-11-30T08:24:45Z
dc.date.issued2022-08-19
dc.description.abstractBackground: The lungs are the organ most likely to sustain serious injury from coronavirus disease 2019 (COVID-19). However, the mechanisms for long-term complications are not clear. Patients with severe COVID-19 have shorter telomere lengths and higher levels of cellular senescence, and we hypothesized that circulating levels of the telomere-associated senescence markers chitotriosidase, b-galactosidase, cathelicidin antimicrobial peptide and stathmin 1 (STMN1) were elevated in hospitalized COVID-19 patients compared to controls and could be associated with pulmonary sequelae following hospitalization.<p> <p>Methods: Ninety-seven hospitalized patients with COVID-19 who underwent assessment for pulmonary sequelae at threemonth follow-up were included in the study. b-Galactosidase and chitotriosidase were analysed by fluorescence; stathmin 1 and cathelicidin antimicrobial peptide were analysed by enzyme immuno-assay in plasma samples from the acute phase and after three-months. In addition, the classical senescence markers cyclin-dependent kinase inhibitor 1A and 2A were analysed by enzyme immuno-assay in peripheral blood mononuclear cell lysate after three months. <p>Results: We found elevated plasma levels of the senescence markers chitotriosidase and stathmin 1 in patients three months after hospitalization with COVID-19, and these markers in addition to protein levels of cyclin-dependent kinase inhibitor 2A in cell lysate, were associated with pulmonary pathology. The elevated levels of these markers seem to reflect both age-dependent (chitotriosidase) and age-independent (stathmin 1, cyclin-dependent kinase inhibitor 2A) processes. <p>Conclusions: We suggest that accelerated ageing or senescence could be important for long-term pulmonary complications of COVID-19, and our findings may be relevant for future research exploring the pathophysiology and management of these patients.en_US
dc.identifier.citationLekva, Ueland, Halvorsen, Murphy, Dyrhol-Riise, Tveita, Finbråten, Mathiessen, Muller, Aaløkken, Skjønsberg, Lerum, Aukrust, Dahl. Markers of cellular senescence is associated with persistent pulmonary pathology after COVID-19 infection. Infectious Diseases. 2022;54(12):918-923en_US
dc.identifier.cristinIDFRIDAID 2069709
dc.identifier.doi10.1080/23744235.2022.2113135
dc.identifier.issn2374-4235
dc.identifier.issn2374-4243
dc.identifier.urihttps://hdl.handle.net/10037/27610
dc.language.isoengen_US
dc.publisherTaylor & Francisen_US
dc.relation.journalInfectious Diseases
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0en_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)en_US
dc.titleMarkers of cellular senescence is associated with persistent pulmonary pathology after COVID-19 infectionen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)