dc.contributor.advisor | Lukic, Marko | |
dc.contributor.author | Subedi, Sibila | |
dc.date.accessioned | 2022-12-27T09:18:24Z | |
dc.date.available | 2022-12-27T09:18:24Z | |
dc.date.issued | 2022-12-01 | en |
dc.description.abstract | Introduction: Breast cancer is a disease in which there is a rapid multiplying of cells in the
breast. It has been a serious concern as it is the most commonly diagnosed cancer among
women, especially in the old-age group. Vitamin D is a fat-soluble vitamin that is consumed
via diet or produced when the ultraviolet (UV) rays of the sun make contact with the skin. Its
putative anticarcinogenic property might play a role to minimize the increasing burden of
breast cancer. Thus, this study focuses on vitamin D level as a risk factor for postmenopausal
breast cancer.
Methodology: A systematic review of prospective cohort studies was conducted. The search
was performed in MEDLINE (Ovid) using the mesh terms and keywords of the modified
PICOS diagram. The free-text search was done in Google Scholar. The reference lists of
relevant systematic reviews were screened manually. The population for the review was
healthy women, the exposure was vitamin D level, and the outcome was postmenopausal
breast cancer.
The information from the eligible studies was extracted and presented in the table. The Risk
of bias (RoB) assessment was done using a CASP tool.
Results: Eight studies met the inclusion criteria. All the studies were prospective cohorts. The
included studies were conducted in high-resource settings. The study population was diverse.
Vitamin D was measured in various forms and the data was collected using a questionnaire.
Breast cancer occurrence was self-reported but was confirmed through reports.
The effect estimates of the fully adjusted models in the included studies ranged from 0.87 to
1.30. The result showed that there was no association between pre-diagnostic vitamin D level
and postmenopausal breast cancer risk.
Conclusion: The review does not have enough evidence to conclude the association between
pre-diagnostic vitamin D level and postmenopausal breast cancer risk. Further research is
necessary to assess the relationship. | en_US |
dc.identifier.uri | https://hdl.handle.net/10037/27919 | |
dc.language.iso | eng | en_US |
dc.publisher | UiT Norges arktiske universitet | no |
dc.publisher | UiT The Arctic University of Norway | en |
dc.rights.holder | Copyright 2022 The Author(s) | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-sa/4.0 | en_US |
dc.rights | Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) | en_US |
dc.subject.courseID | HEL-3950 | |
dc.subject | vitamin D | en_US |
dc.subject | postmenopausal breast cancer | en_US |
dc.title | Association of pre-diagnostic vitamin D level with postmenopausal breast cancer risk: A systematic review | en_US |
dc.type | Mastergradsoppgave | no |
dc.type | Master thesis | en |