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dc.contributor.authorTveita, Torkjel
dc.contributor.authorSieck, Gary C.
dc.date.accessioned2023-03-13T13:02:36Z
dc.date.available2023-03-13T13:02:36Z
dc.date.issued2022-02-22
dc.description.abstractHypothermia is defined as a core body temperature of <35°C, and as body temperature is reduced the impact on physiological processes can be beneficial or detrimental. The beneficial effect of hypothermia enables circulation of cooled experimental animals to be interrupted for 1–2 h without creating harmful effects, while tolerance of circulation arrest in normothermia is between 4 and 5 min. This striking difference has attracted so many investigators, experimental as well as clinical, to this field, and this discovery was fundamental for introducing therapeutic hypothermia in modern clinical medicine in the 1950s. Together with the introduction of cardiopulmonary bypass, therapeutic hypothermia has been the cornerstone in the development of modern cardiac surgery. Therapeutic hypothermia also has an undisputed role as a protective agent in organ transplantation and as a therapeutic adjuvant for cerebral protection in neonatal encephalopathy. However, the introduction of therapeutic hypothermia for organ protection during neurosurgical procedures or as a scavenger after brain and spinal trauma has been less successful. In general, the best neuroprotection seems to be obtained by avoiding hyperthermia in injured patients. Accidental hypothermia occurs when endogenous temperature control mechanisms are incapable of maintaining core body temperature within physiologic limits and core temperature becomes dependent on ambient temperature. During hypothermia spontaneous circulation is considerably reduced and with deep and/or prolonged cooling, circulatory failure may occur, which may limit safe survival of the cooled patient. Challenges that limit safe rewarming of accidental hypothermia patients include cardiac arrhythmias, uncontrolled bleeding, and “rewarming shock.”en_US
dc.identifier.citationTveita, Sieck. Physiological Impact of Hypothermia: The Good, the Bad, and the Ugly. Physiology. 2022;37(2):69-87en_US
dc.identifier.cristinIDFRIDAID 2026674
dc.identifier.doi10.1152/physiol.00025.2021
dc.identifier.issn1548-9213
dc.identifier.issn1548-9221
dc.identifier.urihttps://hdl.handle.net/10037/28731
dc.language.isoengen_US
dc.publisherAmerican Physiological Societyen_US
dc.relation.journalPhysiology
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titlePhysiological Impact of Hypothermia: The Good, the Bad, and the Uglyen_US
dc.type.versionacceptedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's license is described as Attribution 4.0 International (CC BY 4.0)