Show simple item record

dc.contributor.authorHoltedahl, Knut Arne
dc.contributor.authorBorgquist, Lars
dc.contributor.authorDonker, Gé A.
dc.contributor.authorBuntinx, Frank
dc.contributor.authorWeller, David
dc.contributor.authorCampbell, Christine
dc.contributor.authorMånsson, Jörgen
dc.contributor.authorHammersley, Victoria
dc.contributor.authorBraaten, Tonje Bjørndal
dc.contributor.authorParajuli, Ranjan
dc.date.accessioned2023-08-11T12:16:47Z
dc.date.available2023-08-11T12:16:47Z
dc.date.issued2023-04-26
dc.description.abstractBackground - Urogenital cancers are common, accounting for approximately 20% of cancer incidence globally. Cancers belonging to the same organ system often present with similar symptoms, making initial management challenging. In this study, 511 cases of cancer were recorded after the date of consultation among 61,802 randomly selected patients presenting in primary care in six European countries: a subgroup analysis of urogenital cancers was carried out in order to study variation in symptom presentation.<p> <p>Methods - Initial data capture was by completion of standardised forms containing closed questions about symptoms recorded during the consultation. The general practitioner (GP) provided follow-up data after diagnosis, based on medical record data made after the consultation. GPs also provided free text comments about the diagnostic procedure for individual patients.<p> <p>Results - The most common symptoms were mainly associated with one or two specific types of cancer: ‘Macroscopic haematuria’ with bladder or renal cancer (combined sensitivity 28.3%), ‘Increased urinary frequency’ with bladder (sensitivity 13.3%) or prostatic (sensitivity 32.1%) cancer, or to uterine body (sensitivity 14.3%) cancer, ‘Unexpected genital bleeding’ with uterine cancer (cervix, sensitivity 20.0%, uterine body, sensitivity 71.4%). ‘Distended abdomen, bloating’ had sensitivity 62.5% (based on eight cases of ovarian cancer). In ovarian cancer, increased abdominal circumference and a palpable tumour also were important diagnostic elements. Specificity for ‘Macroscopic haematuria’ was 99.8% (99.7–99.8). PPV > 3% was noted for ‘Macroscopic haematuria’ and bladder or renal cancer combined, for bladder cancer in male patients. In males aged 55–74, PPV = 7.1% for ‘Macroscopic haematuria’ and bladder cancer. Abdominal pain was an infrequent symptom in urogenital cancers.<p> <p>Conclusions - Most types of urogenital cancer present with rather specific symptoms. If the GP considers ovarian cancer, increased abdominal circumference should be actively determined. Several cases were clarified through the GP’s clinical examination, or laboratory investigations.en_US
dc.identifier.citationHoltedahl, Borgquist, Donker, Buntinx, Weller, Campbell, Månsson, Hammersley, Braaten, Parajuli. Symptoms and signs of urogenital cancer in primary care. BMC Primary Care. 2023;24(1)en_US
dc.identifier.cristinIDFRIDAID 2159175
dc.identifier.doi10.1186/s12875-023-02063-z
dc.identifier.issn2731-4553
dc.identifier.urihttps://hdl.handle.net/10037/29884
dc.language.isoengen_US
dc.publisherSpringer Natureen_US
dc.relation.journalBMC Primary Care
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleSymptoms and signs of urogenital cancer in primary careen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


File(s) in this item

Thumbnail

This item appears in the following collection(s)

Show simple item record

Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's license is described as Attribution 4.0 International (CC BY 4.0)