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dc.contributor.authorRothwell, Joseph A.
dc.contributor.authorBešević, Jelena
dc.contributor.authorDimou, Niki
dc.contributor.authorBreeur, Marie
dc.contributor.authorMurphy, Neil
dc.contributor.authorJenab, Mazda
dc.contributor.authorWedekind, Roland
dc.contributor.authorViallon, Vivian
dc.contributor.authorFerrari, Pietro
dc.contributor.authorAchaintre, David
dc.contributor.authorGicquiau, Audrey
dc.contributor.authorRinaldi, Sabina
dc.contributor.authorScalbert, Augustin
dc.contributor.authorHuybrechts, Inge
dc.contributor.authorPrehn, Cornelia
dc.contributor.authorAdamski, Jerzy
dc.contributor.authorCross, Amanda J.
dc.contributor.authorKeun, Hector
dc.contributor.authorChadeau-Hyam, Marc
dc.contributor.authorBoutron-Ruault, Marie-Christine
dc.contributor.authorOvervad, Kim
dc.contributor.authorDahm, Christina C.
dc.contributor.authorNøst, Therese Haugdahl
dc.contributor.authorSandanger, Torkjel M
dc.contributor.authorSkeie, Guri
dc.contributor.authorZamora-Ros, Raul
dc.contributor.authorTsilidis, Kostas K.
dc.contributor.authorEichelmann, Fabian
dc.contributor.authorSchulze, Matthias B.
dc.contributor.authorvan Guelpen, Bethany
dc.contributor.authorVidman, Linda
dc.contributor.authorSánchez, Maria-José
dc.contributor.authorAmiano, Pilar
dc.contributor.authorArdanaz, Eva
dc.contributor.authorSmith-Byrne, Karl
dc.contributor.authorTravis, Ruth
dc.contributor.authorKatzke, Verena
dc.contributor.authorKaaks, Rudolf
dc.contributor.authorDerksen, Jeroen W. G.
dc.contributor.authorColorado-Yohar, Sandra
dc.contributor.authorTumino, Rosario
dc.contributor.authorBueno-de-Mesquita, Bas
dc.contributor.authorVineis, Paolo
dc.contributor.authorPalli, Domenico
dc.contributor.authorPasanisi, Fabrizio
dc.contributor.authorEriksen, Anne Kirstine
dc.contributor.authorTjønneland, Anne
dc.contributor.authorSeveri, Gianluca
dc.contributor.authorGunter, Marc J.
dc.date.accessioned2023-08-17T06:40:17Z
dc.date.available2023-08-17T06:40:17Z
dc.date.issued2023-02-28
dc.description.abstractBackground Amino acid metabolism is dysregulated in colorectal cancer patients; however, it is not clear whether pre-diagnostic levels of amino acids are associated with subsequent risk of colorectal cancer. We investigated circulat‑ ing levels of amino acids in relation to colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) and UK Biobank cohorts.<p> <p>Methods Concentrations of 13-21 amino acids were determined in baseline fasting plasma or serum samples in 654 incident colorectal cancer cases and 654 matched controls in EPIC. Amino acids associated with colorectal cancer risk fol‑ lowing adjustment for the false discovery rate (FDR) were then tested for associations in the UK Biobank, for which meas‑ urements of 9 amino acids were available in 111,323 participants, of which 1221 were incident colorectal cancer cases. <p>Results Histidine levels were inversely associated with colorectal cancer risk in EPIC (odds ratio [OR] 0.80 per stand‑ ard deviation [SD], 95% confdence interval [CI] 0.69–0.92, FDR P-value=0.03) and in UK Biobank (HR 0.93 per SD, 95% CI 0.87–0.99, P-value=0.03). Glutamine levels were borderline inversely associated with colorectal cancer risk in EPIC (OR 0.85 per SD, 95% CI 0.75–0.97, FDR P-value=0.08) and similarly in UK Biobank (HR 0.95, 95% CI 0.89–1.01, P=0.09)en_US
dc.identifier.citationRothwell, Bešević, Dimou, Breeur, Murphy, Jenab, Wedekind, Viallon, Ferrari, Achaintre, Gicquiau, Rinaldi, Scalbert, Huybrechts, Prehn, Adamski, Cross, Keun, Chadeau-Hyam, Boutron-Ruault, Overvad, Dahm, Nøst, Sandanger, Skeie, Zamora-Ros, Tsilidis, Eichelmann, Schulze, van Guelpen, Vidman, Sánchez, Amiano, Ardanaz, Smith-Byrne, Travis, Katzke, Kaaks, Derksen, Colorado-Yohar, Tumino, Bueno-de-Mesquita, Vineis, Palli, Pasanisi, Eriksen, Tjønneland, Severi, Gunter. Circulating amino acid levels and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition and UK Biobank cohorts. BMC Medicine. 2023;21(1)en_US
dc.identifier.cristinIDFRIDAID 2155155
dc.identifier.doi10.1186/s12916-023-02739-4
dc.identifier.issn1741-7015
dc.identifier.urihttps://hdl.handle.net/10037/30000
dc.language.isoengen_US
dc.publisherBMCen_US
dc.relation.journalBMC Medicine
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleCirculating amino acid levels and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition and UK Biobank cohortsen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's license is described as Attribution 4.0 International (CC BY 4.0)