Is There a Causal Relationship between Physical Activity and Bone Microarchitecture? A Study of Adult Female Twin Pairs
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https://hdl.handle.net/10037/30019Date
2023-05-17Type
Journal articleTidsskriftartikkel
Author
Nissen, Frida Igland; Esser, Vivienne F. C.; Bui, Minh; Li, Shuai; Hopper, John L.; Bjørnerem, Åshild Marit; Hansen, Ann KristinAbstract
The reasons for the association between physical activity (PA) and bone microarchitecture traits are unclear. We examined whether these
associations were consistent with causation and/or with shared familial factors using a cross-sectional study of 47 dizygotic and 93 monozygotic female twin pairs aged 31–77 years. Images of the nondominant distal tibia were obtained using high-resolutionperipheral quantitative computed tomography. The bone microarchitecture was assessed using StrAx1.0 software. Based on a self-completed
questionnaire, a PA index was calculated as a weighted sum of weekly hours of light (walking, light gardening), moderate (social tennis,
golf, hiking), and vigorous activity (competitive active sports) = light + 2 * moderate + 3 * vigorous. We applied Inference about Causation through Examination of FAmiliaL CONfounding (ICE FALCON) to test whether cross-pair cross-trait associations changed after
adjustment for within-individual associations. Within-individual distal tibia cortical cross-sectional area (CSA) and cortical thickness were
positively associated with PA (regression coefficients [β] = 0.20 and 0.22), while the porosity of the inner transitional zone was negatively
associated with PA (β = 0.17), all p < 0.05. Trabecular volumetric bone mineral density (vBMD) and trabecular thickness were positively
associated with PA (β = 0.13 and 0.14), and medullary CSA was negatively associated with PA (β = 0.22), all p ≤ 0.01. Cross-pair crosstrait associations of cortical thickness, cortical CSA, and medullary CSA with PA attenuated after adjustment for the within-individual association (p = 0.048, p = 0.062, and p = 0.028 for changes). In conclusion, increasing PA was associated with thicker cortices, larger cortical
area, lower porosity of the inner transitional zone, thicker trabeculae, and smaller medullary cavities. The attenuation of cross-pair crosstrait associations after accounting for the within-individual associations was consistent with PA having a causal effect on the improved
cortical and trabecular microarchitecture of adult females, in addition to shared familial factors.
Publisher
WileyCitation
Nissen, Esser, Bui, Li, Hopper, Bjørnerem, Hansen. Is There a Causal Relationship between Physical Activity and Bone Microarchitecture? A Study of Adult Female Twin Pairs. Journal of Bone and Mineral Research. 2023Metadata
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