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dc.contributor.authorAntunes De Sousa, Alexandra Sofia
dc.contributor.authorPhung, Anna Ngoc
dc.contributor.authorSkalko-Basnet, Natasa
dc.contributor.authorObuobi, Sybil Akua Okyerewa
dc.date.accessioned2023-08-28T07:36:56Z
dc.date.available2023-08-28T07:36:56Z
dc.date.issued2023-01-18
dc.description.abstractBacterial biofilms are highly protected surface attached communities of bacteria that typically cause chronic infections. To address their recalcitrance to antibiotics and minimise side effects of current therapies, smart drug carriers are being explored as promising platforms for antimicrobials. Herein, we briefly summarize recent efforts and considerations that have been applied in the design of these smart carriers. We guide readers on a journey on how they can leverage the inherent biofilm microenvironment, external stimuli, or combine both types of stimuli in a predictable manner. The specific carrier features that are responsible for their ‘on-demand’ properties are detailed and their impact on antibiofilm property are further discussed. Moreover, an analysis on the impact of such features on drug release profiles is provided. Since nanotechnology represents a significant slice of the drug delivery pie, some insights on the potential toxicity are also depicted. We hope that this review inspires researchers to use their knowledge and creativity to design responsive systems that can eradicate biofilm infections.en_US
dc.identifier.citationAntunes De Sousa AS, Phung AN, Skalko-Basnet N, Obuobi SAO. Smart delivery systems for microbial biofilm therapy: Dissecting design, drug release and toxicological features. Journal of Controlled Release. 2023;354:394-416en_US
dc.identifier.cristinIDFRIDAID 2110979
dc.identifier.doi10.1016/j.jconrel.2023.01.003
dc.identifier.issn0168-3659
dc.identifier.issn1873-4995
dc.identifier.urihttps://hdl.handle.net/10037/30454
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalJournal of Controlled Release
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleSmart delivery systems for microbial biofilm therapy: Dissecting design, drug release and toxicological featuresen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's license is described as Attribution 4.0 International (CC BY 4.0)