Vis enkel innførsel

dc.contributor.authorPopp, Ilinca
dc.contributor.authorHartong, Nanna E.
dc.contributor.authorNieder, Carsten
dc.contributor.authorGrosu, Anca-L.
dc.date.accessioned2023-09-08T10:21:56Z
dc.date.available2023-09-08T10:21:56Z
dc.date.issued2023-06-15
dc.description.abstract(1) Background: In recent decades, the use of whole-brain radiation therapy (WBRT) in the treatment of brain metastases has significantly decreased, with clinicians fearing adverse neurocognitive events and data showing limited efficacy regarding local tumor control and overall survival. The present study thus aimed to reassess the role that WBRT holds in the treatment of brain metastases. (2) Methods: This review summarizes the available evidence from 1990 until today supporting the use of WBRT, as well as new developments in WBRT and their clinical implications. (3) Results: While one to four brain metastases should be exclusively treated with radiosurgery, WBRT does remain an option for patients with multiple metastases. In particular, hippocampus-avoidance WBRT, WBRT with dose escalation to the metastases, and their combination have shown promising results and offer valid alternatives to local stereotactic radiotherapy. Ongoing and published prospective trials on the efficacy and toxicity of these new methods are presented. (4) Conclusions: Unlike conventional WBRT, which has limited indications, modern WBRT techniques continue to have a significant role to play in the treatment of multiple brain metastases. In which situations radiosurgery or WBRT should be the first option should be investigated in further studies. Until then, the therapeutic decision must be made individually depending on the oncological context.en_US
dc.identifier.citationPopp, Hartong, Nieder, Grosu. PRO: Do We Still Need Whole-Brain Irradiation for Brain Metastases?. Cancers. 2023;15(12)en_US
dc.identifier.cristinIDFRIDAID 2171058
dc.identifier.doi10.3390/cancers15123193
dc.identifier.issn2072-6694
dc.identifier.urihttps://hdl.handle.net/10037/30824
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.relation.journalCancers
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titlePRO: Do We Still Need Whole-Brain Irradiation for Brain Metastases?en_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


Tilhørende fil(er)

Thumbnail

Denne innførselen finnes i følgende samling(er)

Vis enkel innførsel

Attribution 4.0 International (CC BY 4.0)
Med mindre det står noe annet, er denne innførselens lisens beskrevet som Attribution 4.0 International (CC BY 4.0)