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dc.contributor.authorMeknas, Dana
dc.contributor.authorBrækkan, Sigrid Kufaas
dc.contributor.authorHansen, John Bjarne
dc.contributor.authorMorelli, Vania Maris
dc.date.accessioned2023-11-14T12:26:58Z
dc.date.available2023-11-14T12:26:58Z
dc.date.issued2023-09-20
dc.description.abstractBackground Surgery is a major transient risk factor for venous thromboembolism (VTE). However, the impact of major surgery as a VTE trigger has been scarcely investigated using a case-crossover design.<p> <p>Aim To investigate the role of major surgery as a trigger for incident VTE in a population-based case-crossover study while adjusting for other concomitant VTE triggers. <p>Methods We conducted a case-crossover study with 531 cancer-free VTE cases derived from the Tromsø Study cohort. Triggers were registered during the 90 days before a VTE event (hazard period) and in four preceding 90-day control periods. Conditional logistic regression was used to estimate odds ratios (ORs) with 95% confidence intervals (CIs) for VTE according to major surgery and after adjustment for other VTE triggers. <p>Results Surgery was registered in 85 of the 531 (16.0%) hazard periods and in 38 of the 2,124 (1.8%) control periods, yielding an OR for VTE of 11.40 (95% CI: 7.42–17.51). The OR decreased to 4.10 (95% CI: 2.40–6.94) after adjustment for immobilization and infection and was further attenuated to 3.31 (95% CI: 1.83–5.96) when additionally adjusted for trauma, blood transfusion, and central venous catheter. In a mediation analysis, 51.4% (95% CI: 35.5–79.7%) of the effect of surgery on VTE risk could be mediated through immobilization and infection. <p>Conclusions Major surgery was a trigger for VTE, but the association between surgery and VTE risk was in part explained by other VTE triggers often coexisting with surgery, particularly immobilization and infection.en_US
dc.identifier.citationMeknas, Brækkan, Hansen, Morelli. Surgery As a Trigger for Incident Venous Thromboembolism: Results from a Population-Based Case-Crossover Study. TH Open. 2023en_US
dc.identifier.cristinIDFRIDAID 2178684
dc.identifier.doi10.1055/a-2159-9957
dc.identifier.issn2512-9465
dc.identifier.urihttps://hdl.handle.net/10037/31768
dc.language.isoengen_US
dc.publisherGeorg Thieme Verlagen_US
dc.relation.journalTH Open
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleSurgery As a Trigger for Incident Venous Thromboembolism: Results from a Population-Based Case-Crossover Studyen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Med mindre det står noe annet, er denne innførselens lisens beskrevet som Attribution 4.0 International (CC BY 4.0)