Vis enkel innførsel

dc.contributor.authorMarsh, Phillip L.
dc.contributor.authorMoore, Ernest E.
dc.contributor.authorMoore, Hunter B.
dc.contributor.authorBunch, Connor M.
dc.contributor.authorAboukhaled, Michael
dc.contributor.authorCondon, Shaun M.
dc.contributor.authorAl-Fadhl, Mahmoud D.
dc.contributor.authorThomas, Samuel J.
dc.contributor.authorLarson, John R.
dc.contributor.authorBower, Charles W.
dc.contributor.authorMiller, Craig B.
dc.contributor.authorPearson, Michelle L.
dc.contributor.authorTwilling, Christopher L.
dc.contributor.authorReser, David W.
dc.contributor.authorKim, George S.
dc.contributor.authorTroyer, Brittany M.
dc.contributor.authorYeager, Doyle
dc.contributor.authorThomas, Scott G.
dc.contributor.authorSrikureja, Daniel P.
dc.contributor.authorPatel, Shivani S.
dc.contributor.authorAñón, Sofía L.
dc.contributor.authorThomas, Anthony V.
dc.contributor.authorMiller, Joseph B.
dc.contributor.authorVan Ryn, David E.
dc.contributor.authorPamulapati, Saagar V.
dc.contributor.authorZimmerman, Devin
dc.contributor.authorWells, Byars
dc.contributor.authorMartin, Peter L.
dc.contributor.authorSeder, Christopher W.
dc.contributor.authorAversa, John G.
dc.contributor.authorGreene, Ryan B.
dc.contributor.authorMarch, Robert J.
dc.contributor.authorKwaan, Hau C.
dc.contributor.authorFulkerson, Daniel H.
dc.contributor.authorVande Lune, Stefani A.
dc.contributor.authorMollnes, Tom Eirik
dc.contributor.authorNielsen, Erik Waage
dc.contributor.authorStage Storm, Benjamin
dc.contributor.authorWalsh, Mark M.
dc.date.accessioned2023-11-14T13:06:23Z
dc.date.available2023-11-14T13:06:23Z
dc.date.issued2023-09-19
dc.description.abstractIatrogenic vascular air embolism is a relatively infrequent event but is associated with significant morbidity and mortality. These emboli can arise in many clinical settings such as neurosurgery, cardiac surgery, and liver transplantation, but more recently, endoscopy, hemodialysis, thoracentesis, tissue biopsy, angiography, and central and peripheral venous access and removal have overtaken surgery and trauma as significant causes of vascular air embolism. The true incidence may be greater since many of these air emboli are asymptomatic and frequently go undiagnosed or unreported. Due to the rarity of vascular air embolism and because of the many manifestations, diagnoses can be difficult and require immediate therapeutic intervention. An iatrogenic air embolism can result in both venous and arterial emboli whose anatomic locations dictate the clinical course. Most clinically significant iatrogenic air emboli are caused by arterial obstruction of small vessels because the pulmonary gas exchange filters the more frequent, smaller volume bubbles that gain access to the venous circulation. However, there is a subset of patients with venous air emboli caused by larger volumes of air who present with more protean manifestations. There have been significant gains in the understanding of the interactions of fluid dynamics, hemostasis, and inflammation caused by air emboli due to in vitro and in vivo studies on flow dynamics of bubbles in small vessels. Intensive research regarding the thromboinflammatory changes at the level of the endothelium has been described recently. The obstruction of vessels by air emboli causes immediate pathoanatomic and immunologic and thromboinflammatory responses at the level of the endothelium. In this review, we describe those immunologic and thromboinflammatory responses at the level of the endothelium as well as evaluate traditional and novel forms of therapy for this rare and often unrecognized clinical condition.en_US
dc.identifier.citationMarsh, Moore, Moore, Bunch, Aboukhaled, Condon, Al-Fadhl, Thomas, Larson, Bower, Miller, Pearson, Twilling, Reser, Kim, Troyer, Yeager, Thomas, Srikureja, Patel, Añón, Thomas, Miller, Van Ryn, Pamulapati, Zimmerman, Wells, Martin, Seder, Aversa, Greene, March, Kwaan, Fulkerson, Vande Lune, Mollnes, Nielsen, Stage Storm, Walsh. Iatrogenic air embolism: pathoanatomy, thromboinflammation, endotheliopathy, and therapies. Frontiers in Immunology. 2023;14en_US
dc.identifier.cristinIDFRIDAID 2190535
dc.identifier.doi10.3389/fimmu.2023.1230049
dc.identifier.issn1664-3224
dc.identifier.urihttps://hdl.handle.net/10037/31774
dc.language.isoengen_US
dc.publisherFrontiers Mediaen_US
dc.relation.journalFrontiers in Immunology
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleIatrogenic air embolism: pathoanatomy, thromboinflammation, endotheliopathy, and therapiesen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


Tilhørende fil(er)

Thumbnail

Denne innførselen finnes i følgende samling(er)

Vis enkel innførsel

Attribution 4.0 International (CC BY 4.0)
Med mindre det står noe annet, er denne innførselens lisens beskrevet som Attribution 4.0 International (CC BY 4.0)