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dc.contributor.authorBramness, Jørgen Gustav
dc.contributor.authorPandey, Susmita
dc.contributor.authorMoe, Jenny Skumsnes
dc.contributor.authorWalby, Fredrik A
dc.contributor.authorMyhre, Martin Øverlien
dc.contributor.authorBolstad, Ingeborg
dc.contributor.authorLien, Lars
dc.date.accessioned2023-11-15T10:03:38Z
dc.date.available2023-11-15T10:03:38Z
dc.date.issued2023-10-12
dc.description.abstractBackground: Patients with alcohol use disorder (AUD) have an increased risk of suicide. Neuroimmunological measures, such as cytokines, are shown to deviate in people with attempted suicide. Few studies have investigated this among AUD patients.<p> <p>Patients and Methods: One-hundred and fourteen patients undergoing residential treatment for AUD were interviewed on lifetime suicide attempts (SA) along with several other background variables and clinical characteristics. Serum blood samples were drawn for analysis of cytokines. <p>Results: Thirty-one patients (27%) reported at least one SA. These patients had more symptoms of current affective disorders and more severe dependence. In bivariate analysis only IL-6 and IL-10 appeared to be associated with lifetime SA but without reaching statistical significance. In multivariate linear regression, adjusting for sex, nicotine use, somatic illness, and the use of antiinflammatory drugs, IL-6 was associated to SA (p = 0.033). <p>Conclusion: The cytokine IL-6 has repeatedly been found to be associated with suicidality. The present study concurs with this role of IL-6 in a naturalistic observational study of AUD patients.en_US
dc.identifier.citationBramness, Pandey, Moe, Walby FA, Myhre, Bolstad, Lien. Levels of IL-6 are Associated with Lifetime Attempted Suicide in Alcohol Use Disorder Patients. Neuropsychiatric Disease and Treatment. 2023;19:2141-2148en_US
dc.identifier.cristinIDFRIDAID 2192690
dc.identifier.doi10.2147/NDT.S413101
dc.identifier.issn1176-6328
dc.identifier.issn1178-2021
dc.identifier.urihttps://hdl.handle.net/10037/31793
dc.language.isoengen_US
dc.publisherDove Pressen_US
dc.relation.journalNeuropsychiatric Disease and Treatment
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0en_US
dc.rightsAttribution-NonCommercial 4.0 International (CC BY-NC 4.0)en_US
dc.titleLevels of IL-6 are Associated with Lifetime Attempted Suicide in Alcohol Use Disorder Patientsen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
Except where otherwise noted, this item's license is described as Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)