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dc.contributor.authorTong, Kit I
dc.contributor.authorHopstock, Laila Arnesdatter
dc.contributor.authorCook, Sarah
dc.date.accessioned2023-11-23T09:33:10Z
dc.date.available2023-11-23T09:33:10Z
dc.date.issued2023-09-29
dc.description.abstractObjectives The extent to which observed associations between high-sensitivity C-reactive protein (hs-CRP) and incident diabetes are explained by obesity and hypertension remains unclear. This study aimed to investigate the association of hs-CRP with developing diabetes in a Norwegian general population sample.<p> <p>Design A cohort study using two population-based surveys of the Tromsø Study: the sixth survey Tromsø6 (2007–2008) as baseline and the seventh survey Tromsø7 (2015–2016) at follow-up. <p>Setting Tromsø municipality of Norway, a country with increasing proportion of older adults and a high prevalence of overweight, obesity and hypertension. <p>Participants 8067women and men without diabetes, aged 30–87 years, at baseline Tromsø6 who subsequently also participated in Tromsø7. Outcome measures Diabetes defined by self-reported diabetes, diabetes medication use and/or HbA1c≥6.5% (≥48mmol/mol) was modelled by logistic regression for the association with baseline hs-CRP, either stratified into three quantiles or as continuous variable, adjusted for demographic factors, behavioural and cardiovascular risk factors, lipid-lowering medication use, and hypertension. Interactions by sex, body mass index (BMI), hypertension or abdominal obesity were assessed by adding interaction terms in the fully adjusted model. <p>Results There were 320 (4.0%) diabetes cases after 7 years. After multivariable adjustment including obesity and hypertension, individuals in the highest hs-CRP tertile 3 had 73% higher odds of developing diabetes (OR 1.73; p=0.004; 95%CI 1.20 to 2.49) when compared with the lowest tertile or 28% higher odds of incidence per one-log of hs-CRP increment (OR 1.28; p=0.003; 95%CI 1.09 to 1.50). There was no evidence for interaction between hsCRP and sex, hypertension, BMI or abdominal obesity. <p>Conclusions Raised hs-CRP was associated with future diabetes development in a Norwegian adult population sample. The CRP-diabetes association could not be fully explained by obesity or hypertension.en_US
dc.identifier.citationTong, Hopstock, Cook. Association of C-reactive protein with future development of diabetes: A population-based 7-year cohort study among Norwegian adults aged 30 and older in the Tromsø Study 2007-2016. BMJ Open. 2023;13(9)en_US
dc.identifier.cristinIDFRIDAID 2193811
dc.identifier.doi10.1136/bmjopen-2022-070284
dc.identifier.issn2044-6055
dc.identifier.urihttps://hdl.handle.net/10037/31858
dc.language.isoengen_US
dc.publisherBMJen_US
dc.relation.journalBMJ Open
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleAssociation of C-reactive protein with future development of diabetes: A population-based 7-year cohort study among Norwegian adults aged 30 and older in the Tromsø Study 2007-2016en_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's license is described as Attribution 4.0 International (CC BY 4.0)