dc.contributor.author | Tong, Kit I | |
dc.contributor.author | Hopstock, Laila Arnesdatter | |
dc.contributor.author | Cook, Sarah | |
dc.date.accessioned | 2023-11-23T09:33:10Z | |
dc.date.available | 2023-11-23T09:33:10Z | |
dc.date.issued | 2023-09-29 | |
dc.description.abstract | Objectives The extent to which observed associations
between high-sensitivity C-reactive protein (hs-CRP)
and incident diabetes are explained by obesity and
hypertension remains unclear. This study aimed to
investigate the association of hs-CRP with developing
diabetes in a Norwegian general population sample.<p>
<p>Design A cohort study using two population-based
surveys of the Tromsø Study: the sixth survey Tromsø6
(2007–2008) as baseline and the seventh survey Tromsø7
(2015–2016) at follow-up.
<p>Setting Tromsø municipality of Norway, a country with
increasing proportion of older adults and a high prevalence
of overweight, obesity and hypertension.
<p>Participants 8067women and men without diabetes,
aged 30–87 years, at baseline Tromsø6 who subsequently
also participated in Tromsø7.
Outcome measures Diabetes defined by self-reported
diabetes, diabetes medication use and/or HbA1c≥6.5%
(≥48mmol/mol) was modelled by logistic regression for
the association with baseline hs-CRP, either stratified into
three quantiles or as continuous variable, adjusted for
demographic factors, behavioural and cardiovascular risk
factors, lipid-lowering medication use, and hypertension.
Interactions by sex, body mass index (BMI), hypertension
or abdominal obesity were assessed by adding interaction
terms in the fully adjusted model.
<p>Results There were 320 (4.0%) diabetes cases after 7
years. After multivariable adjustment including obesity
and hypertension, individuals in the highest hs-CRP tertile
3 had 73% higher odds of developing diabetes (OR 1.73;
p=0.004; 95%CI 1.20 to 2.49) when compared with the
lowest tertile or 28% higher odds of incidence per one-log
of hs-CRP increment (OR 1.28; p=0.003; 95%CI 1.09 to
1.50). There was no evidence for interaction between hsCRP and sex, hypertension, BMI or abdominal obesity.
<p>Conclusions Raised hs-CRP was associated with future
diabetes development in a Norwegian adult population
sample. The CRP-diabetes association could not be fully
explained by obesity or hypertension. | en_US |
dc.identifier.citation | Tong, Hopstock, Cook. Association of C-reactive protein with future development of diabetes: A population-based 7-year cohort study among Norwegian adults aged 30 and older in the Tromsø Study 2007-2016. BMJ Open. 2023;13(9) | en_US |
dc.identifier.cristinID | FRIDAID 2193811 | |
dc.identifier.doi | 10.1136/bmjopen-2022-070284 | |
dc.identifier.issn | 2044-6055 | |
dc.identifier.uri | https://hdl.handle.net/10037/31858 | |
dc.language.iso | eng | en_US |
dc.publisher | BMJ | en_US |
dc.relation.journal | BMJ Open | |
dc.rights.accessRights | openAccess | en_US |
dc.rights.holder | Copyright 2023 The Author(s) | en_US |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | en_US |
dc.rights | Attribution 4.0 International (CC BY 4.0) | en_US |
dc.title | Association of C-reactive protein with future development of diabetes: A population-based 7-year cohort study among Norwegian adults aged 30 and older in the Tromsø Study 2007-2016 | en_US |
dc.type.version | publishedVersion | en_US |
dc.type | Journal article | en_US |
dc.type | Tidsskriftartikkel | en_US |
dc.type | Peer reviewed | en_US |