Vis enkel innførsel

dc.contributor.authorBystad, Erikka Wikan
dc.contributor.authorStefansson, Vidar Tor Nyborg
dc.contributor.authorEriksen, Bjørn Odvar
dc.contributor.authorMelsom, Toralf
dc.date.accessioned2023-11-29T08:47:31Z
dc.date.available2023-11-29T08:47:31Z
dc.date.issued2023-07-01
dc.description.abstractIntroduction: One-quarter of adults worldwide meet the criteria of metabolic syndrome (MetS). MetS increases the risk of diabetes, chronic kidney disease (CKD), and cardiovascular disease. However, the association between MetS, hyperfiltration, and long-term glomerular filtration rate (GFR) decline in the general population is unknown.<p> <p>Methods: In the Renal Iohexol Clearance Survey (RENIS), we investigated 1551 people aged 50 to 63 years; representative of the general population without diabetes, cardiovascular disease, or kidney disease. The GFR was measured using iohexol clearance at baseline and twice during 11 years of follow-up. Hyperfiltration at baseline was defined as an absolute GFR (ml/min) above the 90th percentile adjusted for sex, age, and height, because these variables correlate with nephron number. MetS was defined as increased waist circumference and 2 risk factors among hypertension, hyperglycemia, elevated triglycerides, and low high density lipoprotein (HDL)-cholesterol levels. The GFR decline rate was calculated using linear mixed models. <p>Results: MetS was associated with hyperfiltration at baseline (odds ratio [OR] 2.4; 95% CI: 1.7–3.5, P < 0.001) and a steeper GFR decline rate during follow-up ( 0.30 [ 0.43 to 0.16] ml/min per 1.73 m<sup>2</sup> /yr). Compared to those without MetS, GFR decline was 0.83 (95% CI: 1.13 to 0.53) ml/min per 1.73 m<sup>2</sup> /yr in those with MetS and baseline hyperfiltration and 0.15 ( 0.30 to 0.00) in those MetS without hyperfiltration, P ¼ 0.2 for interaction. <p>Conclusions: In the nondiabetic general population, those with MetS had an increased OR of hyperfiltration and steeper long-term GFR decline. Randomized controlled trials are needed to explore whether treatment of hyperfiltration can prevent loss of GFR in persons with MetS.en_US
dc.identifier.citationBystad, Stefansson, Eriksen, Melsom. The Association Between Metabolic Syndrome, Hyperfiltration, and Long-Term GFR Decline in the General Population. Kidney International Reports. 2023;8(9):1831-1840en_US
dc.identifier.cristinIDFRIDAID 2182423
dc.identifier.doi10.1016/j.ekir.2023.06.022
dc.identifier.issn2468-0249
dc.identifier.urihttps://hdl.handle.net/10037/31881
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalKidney International Reports
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleThe Association Between Metabolic Syndrome, Hyperfiltration, and Long-Term GFR Decline in the General Populationen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


Tilhørende fil(er)

Thumbnail

Denne innførselen finnes i følgende samling(er)

Vis enkel innførsel

Attribution 4.0 International (CC BY 4.0)
Med mindre det står noe annet, er denne innførselens lisens beskrevet som Attribution 4.0 International (CC BY 4.0)