Vis enkel innførsel

dc.contributor.authorSkjevling, Linn
dc.contributor.authorHanssen, Hege Marie
dc.contributor.authorValle, Per Christian
dc.contributor.authorGoll, Rasmus
dc.contributor.authorJuul, Frederik Emil
dc.contributor.authorArlov, Øystein
dc.contributor.authorJohnsen, Peter Holger
dc.description.abstractBackground Fecal microbiota transplantation (FMT) has become an important treatment method in recurrent Clostridioides difficile infections and is under investigation as a treatment for several other diseases. FMT’s mechanism of action is assumed to be through alterations of the colon microbiota. FMT can be delivered by several methods, but few studies have directly compared how FMT is distributed in the colon by different methods. Specifically, the proximal distribution of FMT delivered by enema is unknown.<p> <p>Methods In eight participants, we administered contrast fluid (CF) with viscosity similar to an FMT in a crossover study design. First, CF was administered by colonoscopy, followed by an abdominal X-ray to visualize the CF distribution. Next, after four to eight weeks, participants were given CF, but as an enema, followed by a positioning procedure. X-rays were obtained before (enema ÷) and after (enema +) the positioning procedure. <p>Conclusion Proportion of participants with CF in cecum were 100% after colonoscopy, 50% after enema+and 38% after enema ÷. In the transverse colon, proportions were 100% (colonoscopy), 88% (enema +) and 63% (enema ÷). There were no adverse events. <p>Interpretation This study shows proof of concept for the distribution of FMT to proximal colon when delivered by enema. A positioning procedure after the enema slightly improves the proximal distribution. However, colonoscopy is the only method that ensures delivery to the cecum. Studies are needed to see if FMT colon distribution correlates with treatment effectiveness. <p>Trial registration The study was retrospectively registered at (NCT05121285) (16/11/2021).en_US
dc.identifier.citationSkjevling, Hanssen, Valle, Goll, Juul, Arlov, Johnsen. Colonic distribution of FMT by different enema procedures compared to colonoscopy – proof of concept study using contrast fluid. BMC Gastroenterology. 2023;23(1)en_US
dc.identifier.cristinIDFRIDAID 2193911
dc.relation.journalBMC Gastroenterology
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleColonic distribution of FMT by different enema procedures compared to colonoscopy – proof of concept study using contrast fluiden_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US

Tilhørende fil(er)


Denne innførselen finnes i følgende samling(er)

Vis enkel innførsel

Attribution 4.0 International (CC BY 4.0)
Med mindre det står noe annet, er denne innførselens lisens beskrevet som Attribution 4.0 International (CC BY 4.0)