Institutt for klinisk medisin: Recent submissions
Now showing items 541-560 of 1804
-
Aspirin as secondary prevention in colorectal cancer liver metastasis (ASAC trial): study protocol for a multicentre randomized placebo-controlled trial
(Journal article; Tidsskriftartikkel, 2021-09-20)Background: Colorectal cancer is one the most common cancers in the western world with increasing incidence. Approximately 50% of the patients develop liver metastases. Resection of liver metastases is the treatment of choice although almost half of the resected patients get recurrence in the liver. Methods: The ASAC trial is a Scandinavian, multicentre, double-blinded, randomized, placebo-controlled ... -
Identification of Endothelial Proteins in Plasma Associated With Cardiovascular Risk Factors
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-28)<b>Objective:</b> Endothelial cell (EC) dysfunction is a well-established response to cardiovascular disease risk factors, such as smoking and obesity. Risk factor exposure can modify EC signaling and behavior, leading to arterial and venous disease development. Here, we aimed to identify biomarker panels for the assessment of EC dysfunction, which could be useful for risk stratification or to monitor ... -
Development of quantitative assay for simultaneous measurement of purine metabolites and creatinine in biobanked urine by liquid chromatography-tandem mass spectrometry
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-20)Purine metabolism is essential for all known living creatures, including humans in whom elevated serum concentration of purine break-down product uric acid (UA) is probably an independent risk factor for mortality, type 2 diabetes and cardiovascular events. An automated multiplex assay that measures several purine metabolites could therefore prove useful in many areas of medical, veterinary and ... -
Radiofrequency Microtenotomy or Physical Therapy for Achilles Tendinopathy: Results of a Randomized Clinical Trial
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-20)Background: Achilles tendinopathy is a painful disorder, and various treatment options are available. Bipolar radiofrequency microtenotomy (RFM) has shown promising results in treating tendinosis.<p> <p>Purpose/Hypothesis: The purpose was to compare the results between treatment with bipolar RFM and physical therapy (PT) for patients with midportion Achilles tendinopathy. It was hypothesized that ... -
Radiofrequency Microtenotomy or Physical Therapy for Achilles Tendinopathy
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-20)Background: Achilles tendinopathy is a painful disorder, and various treatment options are available. Bipolar radiofrequency microtenotomy (RFM) has shown promising results in treating tendinosis.<p> <p>Purpose/Hypothesis: The purpose was to compare the results between treatment with bipolar RFM and physical therapy (PT) for patients with midportion Achilles tendinopathy. It was hypothesized that ... -
Plasma procoagulant phospholipid clotting time and venous thromboembolism risk
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-20)Background - Negatively charged procoagulant phospholipids, phosphatidylserine (PS) in particular, are vital to coagulation and expressed on the surface membrane of extracellular vesicles. No previous study has investigated the association between plasma procoagulant phospholipid clotting time (PPL<sub>CT</sub>) and future risk of venous thromboembolism (VTE).<p> <p>Objectives - To investigate the ... -
GABAA subunit single nucleotide polymorphisms show sex-specific association to alcohol consumption and mental distress in a Norwegian population-based sample
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-14)Little is known about genetic influences on the relationship between alcohol consumption and mental distress in the general population, where the majority report consumption and distress far below diagnostic thresholds. This study investigated single nucleotide polymorphisms (SNPs) from candidate gene studies on alcohol use disorder and depressive disorders, for association with alcohol consumption ... -
Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-24)Background - Hypertension can be detected at the primary health-care level and low-cost treatments can effectively control hypertension. We aimed to measure the prevalence of hypertension and progress in its detection, treatment, and control from 1990 to 2019 for 200 countries and territories.<p> <p>Methods - We used data from 1990 to 2019 on people aged 30–79 years from population-representative ... -
A rapid, sensitive, and specific assay to measure TF activity based on chromogenic determination of thrombin generation
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-25)Background - Most tissue factor (TF) activity assays are based on measurement of factor X (FX) activation by TF in the presence of factor VII (FVII)/FVIIa. This requires long incubation, which may result in TF-independent activity of FX and inaccurate measurement of TF activity.<p> <p>Aim - To develop a sensitive and specific TF activity assay, which does not register a non-specific TF activity, ... -
Rosuvastatin treatment decreases plasma procoagulant phospholipid activity after a VTE: A randomized controlled trial
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-25)Background - Venous thromboembolism (VTE) is a frequent cardiovascular disease with severe complications, including recurrence and death. There is a great need for alternative prophylactic treatment options as anticoagulation is accompanied by increased bleeding risk. Statins are reported to reduce the risk of incident and recurrent VTE, but the mechanisms are elusive. Procoagulant phospholipids ... -
Obesity does not protect from subarachnoid haemorrhage: Pooled analysis of 3 large prospective Nordic cohorts
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-10)Background and purpose: Several population-based cohort studies have related higher body mass index (BMI) to a decreased risk of subarachnoid hemorrhage (SAH). The main objective of our study was to investigate whether the previously reported inverse association can be explained by modifying effects of the most important risk factors of SAH—smoking and hypertension.<p> <p>Methods: We conducted ... -
Tocilizumab increases citrullinated histone 3 in non-ST segment elevation myocardial infarction
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-05-10)Objective: Beyond reducing inflammation and troponin T (TnT) release, the interleukin-6 receptor antagonist tocilizumab reduces neutrophil counts in patients with non-ST segment elevation myocardial infarction (NSTEMI). It is unclear if this is related to formation of neutrophil extracellular traps (NETs), carrying inflammatory and thrombotic properties.<p> <p>Methods - In a placebo-controlled ... -
A porcine model of hemodialyzer reactions: roles of complement activation and rinsing back of extracorporeal blood
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-09)Hemodialysis reactions (HDRs) resemble complement-activation-related pseudoallergy (CARPA) to certain i.v. drugs, for which pigs provide a sensitive model. On this basis, to better understand the mechanism of human HDRs, we subjected pigs to hemodialysis using polysulfone (FX CorDiax 40, Fresenius) or cellulose triacetate (SureFlux-15UX, Nipro) dialyzers, or Dialysis exchange-set without membranes, ... -
Management of patients with metastatic renal cell cancer and bone metastases
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-02-28)Background/Aim: Previous research has suggested that patients with metastatic renal cell cancer (mRCC) and bone metastases have a poorer prognosis compared to their counterparts with no skeletal involvement. Therefore, we analyzed the management and outcomes of such patients in our center. Patients and Methods: We performed a retrospective study of 35 consecutive patients who received systemic ... -
On the Use of Time Series Kernel and Dimensionality Reduction to Identify the Acquisition of Antimicrobial Multidrug Resistance in the Intensive Care Unit
(Conference object; Konferansebidrag, 2021)The acquisition of Antimicrobial Multidrug Resistance (AMR) in patients admitted to the Intensive Care Units (ICU) is a major global concern. This study analyses data in the form of multivariate time series (MTS) from 3476 patients recorded at the ICU of University Hospital of Fuenlabrada (Madrid) from 2004 to 2020. 18% of the patients acquired AMR during their stay in the ICU. The goal of ... -
Hemostatic factors, inflammatory markers, and risk of incident venous thromboembolism: The Multi-Ethnic Study of Atherosclerosis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-03-27)Background - Several hemostatic factors and inflammatory markers are associated with the risk of incident venous thromboembolism (VTE), however, most existing data are from case-control studies in Caucasian populations.<p> <p>Objectives - We aimed to prospectively confirm previous findings and explore less studied biomarkers in relation to VTE risk in a multi-racial/multi-ethnic cohort.<p> <p>Methods ... -
Prognostic Impact of Resection Margin Status in Distal Pancreatectomy for Ductal Adenocarcinoma
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-22)Background. Resection margin status is considered one of the few surgeon-controlled parameters affecting prognosis in pancreatic ductal adenocarcinoma (PDAC). While studies mostly focus on resection margins in pancreatoduodenectomy, little is known about their role in distal pancreatectomy (DP). This study aimed to investigate resection margins in DP for PDAC.<p> <p>Methods. Patients who ... -
Chronic iron deficiency and anaemia were highly prevalent in a population-based longitudinal study among adolescent girls
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-01)<b>Aim:</b> The combination of iron deficiency and anaemia is a major health problem, and adolescents are an at- risk group. The main aim of this study was to explore the mag-nitude of these conditions among adolescents aged 15–19 and identify possible as-sociated risk factors. <br><b>Methods:</b> This population- based longitudinal study of adolescents in North Norway was conducted in 2010–2011, ... -
Surgery for Degenerative Cervical Myelopathy: A Nationwide Registry-Based Observational Study With Patient-Reported Outcomes
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-29)Background: Indications and optimal timing for surgical treatment of degenerative cervical myelopathy (DCM) remain unclear, and data from daily clinical practice are warranted.<p> <p>Objective: To investigate clinical outcomes following decompressive surgery for DCM. Methods: Data were obtained from the Norwegian Registry for Spine Surgery. The primary outcome was change in the neck disability index ... -
High-density lipoprotein subfractions: Much ado about nothing or clinically important?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-18)High-density lipoproteins (HDL) are a heterogenous group of plasma molecules with a large variety in composition. There is a wide specter in lipid content and the number of different proteins that has been associated with HDL is approaching 100. Given this heterogeneity and the fact that the total amount of HDL is inversely related to the risk of coronary heart disease (CHD), there has been ...