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dc.contributor.authorMorales-Berstein, Fernanda
dc.contributor.authorBiessy, Carine
dc.contributor.authorViallon, Vivian
dc.contributor.authorGoncalves-Soares, Ana
dc.contributor.authorCasagrande, Corinne
dc.contributor.authorHémon, Bertrand
dc.contributor.authorKliemann, Nathalie
dc.contributor.authorCairat, Manon
dc.contributor.authorBlanco Lopez, Jessica
dc.contributor.authorAl Nahas, Aline
dc.contributor.authorChang, Kiara
dc.contributor.authorVamos, Eszter
dc.contributor.authorRauber, Fernanda
dc.contributor.authorBertazzi Levy, Renata
dc.contributor.authorBarbosa Cunha, Diana
dc.contributor.authorJakszyn, Paula
dc.contributor.authorFerrari, Pietro
dc.contributor.authorVineis, Paolo
dc.contributor.authorMasala, Giovanna
dc.contributor.authorCatalano, Alberto
dc.contributor.authorSonestedt, Emily
dc.contributor.authorBorné, Yan
dc.contributor.authorKatzke, Verena
dc.contributor.authorBajracharya, Rashmita
dc.contributor.authorAgnoli, Claudia
dc.contributor.authorGuevara, Marcela
dc.contributor.authorHeath, Alicia
dc.contributor.authorRadoï, Loredana
dc.contributor.authorMancini, Francesca
dc.contributor.authorWeiderpass Vainio, Elisabete
dc.contributor.authorHuerta, José María
dc.contributor.authorSánchez, María-José
dc.contributor.authorTjønneland, Anne
dc.contributor.authorKyrø, Cecilie
dc.contributor.authorSchulze, Matthias B.
dc.contributor.authorSkeie, Guri
dc.contributor.authorLukic, Marko
dc.contributor.authorBraaten, Tonje Bjørndal
dc.contributor.authorGunter, Marc
dc.contributor.authorMillett, Christopher
dc.contributor.authorAgudo, Antonio
dc.contributor.authorBrennan, Paul
dc.contributor.authorBorges, M. Carolina
dc.contributor.authorRichmond, Rebecca C.
dc.contributor.authorRichardson, Tom G.
dc.contributor.authorDavey Smith, George
dc.contributor.authorRelton, Caroline L.
dc.contributor.authorHuybrechts, Inge
dc.date.accessioned2024-01-05T10:14:26Z
dc.date.available2024-01-05T10:14:26Z
dc.date.issued2023-11-22
dc.description.abstractPurpose - To investigate the role of adiposity in the associations between ultra-processed food (UPF) consumption and head and neck cancer (HNC) and oesophageal adenocarcinoma (OAC) in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.<p> <p>Methods - Our study included 450,111 EPIC participants. We used Cox regressions to investigate the associations between the consumption of UPFs and HNC and OAC risk. A mediation analysis was performed to assess the role of body mass index (BMI) and waist-to-hip ratio (WHR) in these associations. In sensitivity analyses, we investigated accidental death as a negative control outcome.<p> <p>Results - During a mean follow-up of 14.13 ± 3.98 years, 910 and 215 participants developed HNC and OAC, respectively. A 10% g/d higher consumption of UPFs was associated with an increased risk of HNC (hazard ratio [HR] = 1.23, 95% confidence interval [CI] 1.14–1.34) and OAC (HR = 1.24, 95% CI 1.05–1.47). WHR mediated 5% (95% CI 3–10%) of the association between the consumption of UPFs and HNC risk, while BMI and WHR, respectively, mediated 13% (95% CI 6–53%) and 15% (95% CI 8–72%) of the association between the consumption of UPFs and OAC risk. UPF consumption was positively associated with accidental death in the negative control analysis.<p> <p>Conclusions - We reaffirmed that higher UPF consumption is associated with greater risk of HNC and OAC in EPIC. The proportion mediated via adiposity was small. Further research is required to investigate other mechanisms that may be at play (if there is indeed any causal effect of UPF consumption on these cancers).en_US
dc.identifier.citationMorales-Berstein, Biessy, Viallon, Goncalves-Soares, Casagrande, Hémon, Kliemann, Cairat, Blanco Lopez, Al Nahas, Chang, Vamos, Rauber, Bertazzi Levy, Barbosa Cunha, Jakszyn, Ferrari, Vineis, Masala, Catalano, Sonestedt, Borné, Katzke, Bajracharya, Agnoli, Guevara, Heath, Radoï, Mancini, Weiderpass Vainio, Huerta, Sánchez, Tjønneland, Kyrø, Schulze, Skeie, Lukic, Braaten, Gunter, Millett, Agudo, Brennan, Borges, Richmond, Richardson, Davey Smith, Relton, Huybrechts. Ultra-processed foods, adiposity and risk of head and neck cancer and oesophageal adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition study: a mediation analysis. European Journal of Nutrition. 2023en_US
dc.identifier.cristinIDFRIDAID 2207505
dc.identifier.doi10.1007/s00394-023-03270-1
dc.identifier.issn1436-6207
dc.identifier.issn1436-6215
dc.identifier.urihttps://hdl.handle.net/10037/32339
dc.language.isoengen_US
dc.publisherSpringer Natureen_US
dc.relation.journalEuropean Journal of Nutrition
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/874739/Finland/Dynamic longitudinal exposome trajectories in cardiovascular and metabolic non-communicable diseases/LONGITOOLS/en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleUltra-processed foods, adiposity and risk of head and neck cancer and oesophageal adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition study: a mediation analysisen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's license is described as Attribution 4.0 International (CC BY 4.0)