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dc.contributor.authorHughes, David J.
dc.contributor.authorSchomburg, Lutz
dc.contributor.authorJenab, Mazda
dc.contributor.authorBiessy, Carine
dc.contributor.authorMéplan, Catherine
dc.contributor.authorMoskal, Aurelie
dc.contributor.authorSun, Qian
dc.contributor.authorDemircan, Kamil
dc.contributor.authorFedirko, Veronika
dc.contributor.authorWeiderpass Vainio, Elisabete
dc.contributor.authorMukhtar, Maryam
dc.contributor.authorOlsen, Anja
dc.contributor.authorTjønneland, Anne
dc.contributor.authorOvervad, Kim
dc.contributor.authorSchulze, Matthias
dc.contributor.authorNøst, Therese Haugdahl
dc.contributor.authorSkeie, Guri
dc.contributor.authorOlsen, Karina Standahl
dc.contributor.authorRicceri, Fulvio
dc.contributor.authorGrioni, Sara
dc.contributor.authorPalli, Domenico
dc.contributor.authorMasala, Giovanna
dc.contributor.authorTumino, Rosario
dc.contributor.authorPasanisi, Fabrizio
dc.contributor.authorAmiano, Pilar
dc.contributor.authorColorado Yohar, Sandra M.
dc.contributor.authorAgudo, Antonio
dc.contributor.authorSánchez, Maria-Jose
dc.contributor.authorArdanaz, Eva
dc.contributor.authorSund, Malin
dc.contributor.authorAndersson, Anne
dc.contributor.authorPerez-Cornago, Aurora
dc.contributor.authorTravis, Ruth
dc.contributor.authorHeath, Alicia K.
dc.contributor.authorDossus, Laure
dc.date.accessioned2024-01-05T12:03:23Z
dc.date.available2024-01-05T12:03:23Z
dc.date.issued2023-11-01
dc.description.abstractSelenium (Se) may help prevent breast cancer (BC) development. Owing to limited observational evidence, we investigated whether prediagnostic Se status and/or variants in the selenoprotein genes are associated with BC risk in a large European cohort. Se status was assessed by plasma measures of Se and its major circulating proteins, selenoprotein P (SELENOP) and glutathione peroxidase 3 (GPX3), in matched BC case-control pairs (2208 for SELENOP; 1785 for GPX3 and Se) nested within the European Prospective Investigation into Cancer and Nutrition (EPIC). Single nucleotide polymorphisms (SNPs, n = 452) in 55 selenoprotein and Se metabolic pathway genes and an additional 18 variants previously associated with Se concentrations were extracted from existing genotyping data within EPIC for 1564 case-control pairs. Multivariable-adjusted logistic regression models were used to calculate the odds ratios (ORs) and 95 % confidence intervals (CIs) of the association between Se status markers, SNP variants and BC risk. Overall, there was no statistically significant association of Se status with BC risk. However, higher GPX3 activity was associated with lower risk of premenopausal BC (4th versus 1st quartile, OR = 0.54, 95 % CI: 0.30–0.98, Ptrend = 0.013). While none of the genetic variant associations (P ≤ 0.05) retained significance after multiple testing correction, rs1004243 in the SELENOM selenoprotein gene and two SNPs in the related antioxidant TXN2 gene (rs4821494 and rs5750261) were associated with respective lower and higher risks of BC at a significance threshold of P ≤ 0.01. Fourteen SNPs in twelve Se pathway genes (P ≤ 0.01) in interaction with Se status were also associated with BC risk. Higher Se status does not appear to be associated with BC risk, although activity of the selenoenzyme GPX3 may be inversely associated with premenopausal BC risk, and SNPs in the Se pathway alone or in combination with suboptimal Se status may influence BC risk.en_US
dc.identifier.citationHughes, Schomburg, Jenab, Biessy, Méplan, Moskal, Sun, Demircan, Fedirko, Weiderpass Vainio, Mukhtar, Olsen, Tjønneland, Overvad, Schulze, Nøst, Skeie, Olsen, Ricceri, Grioni, Palli, Masala, Tumino, Pasanisi, Amiano, Colorado Yohar, Agudo, Sánchez, Ardanaz, Sund, Andersson, Perez-Cornago, Travis, Heath, Dossus. Prediagnostic selenium status, selenoprotein gene variants and association with breast cancer risk in a European cohort study. Free Radical Biology & Medicine. 2023;209:381-393en_US
dc.identifier.cristinIDFRIDAID 2208499
dc.identifier.doi10.1016/j.freeradbiomed.2023.10.401
dc.identifier.issn0891-5849
dc.identifier.issn1873-4596
dc.identifier.urihttps://hdl.handle.net/10037/32347
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalFree Radical Biology & Medicine
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titlePrediagnostic selenium status, selenoprotein gene variants and association with breast cancer risk in a European cohort studyen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
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