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dc.contributor.authorNieder, Carsten
dc.contributor.authorMannsåker, Bård
dc.contributor.authorStanisavljevic, Luka
dc.contributor.authorHaukland, Ellinor Christin
dc.date.accessioned2024-01-19T10:18:48Z
dc.date.available2024-01-19T10:18:48Z
dc.date.issued2023-02-15
dc.description.abstractIntroduction: Immune checkpoint inhibitors (ICIs) have become a mainstay of treatment for different cancer types. The purpose of this study was to evaluate patterns of care and overall survival (OS) after diagnosis of brain metastases in patients managed with ICI as component of care. Methods: This was a retrospective cohort study. Fifty patients were included (34 with brain metastases at first cancer diagnosis, 16 with metachronous spread). Results: Depending on symptoms, lesion number and size, and other individualized criteria, multidisciplinary tumor (MDT) board discussion resulted in highly individualized treatment sequences. Selected patients received systemic treatment alone. Twenty-four patients (48%) had any stereotactic radiosurgery or neurosurgical resection at some point in time (upfront/salvage). Only 7 patients (14%) were never treated with brain irradiation or neurosurgery. Median OS was 13.0 months. Better Karnofsky performance status, absence of extracranial metastases, and time interval between cancer diagnosis and brain metastases of 0–18 months predicted for improved survival. Treatment sequence was not associated with survival. Patients without extracranial metastases had median OS of 52.2 months. Conclusion: Long-term survival is possible in patients managed with ICI ± brain-directed treatment. This study did not identify a clear treatment sequence of choice. MDT assessment at diagnosis and each progression is recommended to ensure favorable outcomes.en_US
dc.identifier.citationNieder, Mannsåker, Stanisavljevic, Haukland. Patterns of Care and Survival in Cancer Patients with Brain Metastases Receiving Immune Checkpoint Inhibitors. Oncology Research and Treatment. 2023;46(4):157-164en_US
dc.identifier.cristinIDFRIDAID 2142162
dc.identifier.doi10.1159/000529627
dc.identifier.issn2296-5270
dc.identifier.issn2296-5262
dc.identifier.urihttps://hdl.handle.net/10037/32628
dc.language.isoengen_US
dc.publisherKarger Publishersen_US
dc.relation.journalOncology Research and Treatment
dc.relation.projectIDSHARE - Centre for Resilience in Healthcare: 5091en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.titlePatterns of Care and Survival in Cancer Patients with Brain Metastases Receiving Immune Checkpoint Inhibitorsen_US
dc.type.versionacceptedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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