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dc.contributor.authorNieder, Carsten
dc.contributor.authorDalhaug, Astrid
dc.date.accessioned2024-01-19T10:24:50Z
dc.date.available2024-01-19T10:24:50Z
dc.date.issued2023-01-25
dc.description.abstractBackground/Aim: This study aimed at validation of a prognostic model, originally developed by Rades et al., in an age-restricted, particularly vulnerable subgroup of patients with brain metastases, because international variations in clinical practice and survival outcomes may impact on the performance of survival prediction tools. Patients and Methods: Retrospectively, data from a single institution were analyzed. The study included 50 patients managed with palliative whole-brain radiotherapy. The Rades et al. score was assigned and the resulting 3 prognostic strata compared. Results: The 3-month survival rates for the 3 strata were 0, 35, and 41%, respectively (p<0.001 pooled over all strata, log-rank test for Kaplan–Meier curves). However, the prognostic impact of extracranial metastases suggested by Rades et al., together with the performance status and number of brain metastases in their study of 94 patients, was absent. In contrast, cancer type (better survival for breast and melanoma) and lack of steroid treatment were significant in the present study. Conclusion: The original Rades et al. score is a useful prognostic model in our validation database. However, additional factors, such as primary cancer type and need to prescribe corticosteroids, appear to play a role and might therefore be considered when performing future large-scale studies.en_US
dc.identifier.citationNieder, Dalhaug. Prognostic factors and independent validation of a risk stratification model in octogenarian patients irradiated for brain metastases. Anticancer Research. 2023;43(2):749-753en_US
dc.identifier.cristinIDFRIDAID 2129675
dc.identifier.doi10.21873/anticanres.16214
dc.identifier.issn0250-7005
dc.identifier.issn1791-7530
dc.identifier.urihttps://hdl.handle.net/10037/32631
dc.language.isoengen_US
dc.publisherInternational Institute of Anticancer Researchen_US
dc.relation.journalAnticancer Research
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.titlePrognostic factors and independent validation of a risk stratification model in octogenarian patients irradiated for brain metastasesen_US
dc.type.versionacceptedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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