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dc.contributor.authorUrbarova, Ilona Halva
dc.contributor.authorSkogholt, Anne Heidi
dc.contributor.authorSun, Yi-Qian
dc.contributor.authorMai, Xiao-Mei
dc.contributor.authorGrønberg, Bjørn Henning
dc.contributor.authorSandanger, Torkjel Manning
dc.contributor.authorSætrom, Pål
dc.contributor.authorNøst, Therese Haugdahl
dc.date.accessioned2024-01-22T13:24:31Z
dc.date.available2024-01-22T13:24:31Z
dc.date.issued2023-11-25
dc.description.abstractLung cancer (LC) mortality rates are still increasing globally. As survival is linked to stage, there is a need to identify markers for earlier LC diagnosis and individualized treatment. The whole blood transcriptome of LC patients represents a source of potential LC biomarkers. We compared expression of > 60,000 genes in whole blood specimens taken from LC cases at diagnosis (n = 128) and controls (n = 62) using genome-wide RNA sequencing, and identified 14 candidate genes associated with LC. High expression of ANXA3, ARG1 and HP was strongly associated with lower survival in late-stage LC cases (hazard ratios (HRs) = 2.81, 2.16 and 2.54, respectively). We validated these markers in two independent population-based studies with pre-diagnostic whole blood specimens taken up to eight years prior to LC diagnosis (n = 163 cases, 184 matched controls). ANXA3 and ARG1 expression was strongly associated with LC in these specimens, especially with late-stage LC within two years of diagnosis (odds ratios (ORs) = 3.47 and 5.00, respectively). Additionally, blood CD4 T cells, NK cells and neutrophils were associated with LC at diagnosis and improved LC discriminative ability beyond candidate genes. Our results indicate that in whole blood, increased expression levels of ANXA3, ARG1 and HP are diagnostic and prognostic markers of late-stage LC.en_US
dc.identifier.citationUrbarova, Skogholt, Sun, Mai, Grønberg, Sandanger, Sætrom, Nøst. Increased expression of individual genes in whole blood is associated with late-stage lung cancer at and close to diagnosis. Scientific Reports. 2023;13(1):20760en_US
dc.identifier.cristinIDFRIDAID 2211783
dc.identifier.doi10.1038/s41598-023-48216-z
dc.identifier.issn2045-2322
dc.identifier.urihttps://hdl.handle.net/10037/32675
dc.language.isoengen_US
dc.publisherSpringer Natureen_US
dc.relation.journalScientific Reports
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleIncreased expression of individual genes in whole blood is associated with late-stage lung cancer at and close to diagnosisen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Med mindre det står noe annet, er denne innførselens lisens beskrevet som Attribution 4.0 International (CC BY 4.0)