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dc.contributor.authorBerglin, Mattias
dc.contributor.authorCavanagh, Jorunn Pauline
dc.contributor.authorCaous, Josefin Seth
dc.contributor.authorThakkar, Balmukund
dc.contributor.authorVasquez, Jeddah Marie
dc.contributor.authorStensen, Wenche Gunvor B
dc.contributor.authorLyvén, Benny
dc.contributor.authorSvendsen, John Sigurd Mjøen
dc.contributor.authorSvenson, Johan
dc.date.accessioned2024-01-23T14:20:20Z
dc.date.available2024-01-23T14:20:20Z
dc.date.issued2023-11-27
dc.description.abstractEfficient, simple antibacterial materials to combat implant-associated infections are much in demand. Herein, the development of polyurethanes, both cross-linked thermoset and flexible and versatile thermoplastic, suitable for “click on demand” attachment of antibacterial compounds enabled via incorporation of an alkyne-containing diol monomer in the polymer backbone, is described. By employing different polyolic polytetrahydrofurans, isocyanates, and chain extenders, a robust and flexible material comparable to commercial thermoplastic polyurethane is prepared. A series of short synthetic antimicrobial peptides are designed, synthesized, and covalently attached in a single coupling step to generate a homogenous coating. The lead material is shown to be biocompatible and does not display any toxicity against either mouse fibroblasts or reconstructed human epidermis according to ISO and OECD guidelines. The repelling performance of the peptide-coated materials is illustrated against colonization and biofilm formation by Staphylococcus aureus and Staphylococcus epidermidis on coated plastic films and finally, on coated commercial central venous catheters employing LIVE/DEAD staining, confocal laser scanning microscopy, and bacterial counts. This study presents the successful development of a versatile and scalable polyurethane with the potential for use in the medical field to reduce the impact of bacterial biofilms.en_US
dc.identifier.citationBerglin, Cavanagh, Caous, Thakkar, Vasquez, Stensen, Lyvén, Svendsen, Svenson. Flexible and Biocompatible Antifouling Polyurethane Surfaces Incorporating Tethered Antimicrobial Peptides through Click Reactions. Macromolecular Bioscience. 2023en_US
dc.identifier.cristinIDFRIDAID 2215303
dc.identifier.doi10.1002/mabi.202300425
dc.identifier.issn1616-5187
dc.identifier.issn1616-5195
dc.identifier.urihttps://hdl.handle.net/10037/32689
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.journalMacromolecular Bioscience
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleFlexible and Biocompatible Antifouling Polyurethane Surfaces Incorporating Tethered Antimicrobial Peptides through Click Reactionsen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's license is described as Attribution 4.0 International (CC BY 4.0)