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norskInstitutt for medisinsk biologi: Recent submissions
Now showing items 921-940 of 1198
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Long-Term Use of Lipid-Lowering Drugs Slows Progression of Carotid Atherosclerosis The Tromso Study 1994 to 2008
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)Data on the effect of lipid-lowering drugs (LLD) on carotid atherosclerosis outside clinical trials are limited. The aim of this study was to determine the effect of LLD on change in carotid intima media thickness and total plaque area in a general population. Subjects were 1532 women and 1442 men who participated in a longitudinal population-based study with ultrasound examination of intima media ... -
Doctors are to blame for perceived medical adverse events. A cross sectional population study. The Tromsø study.
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)Most current knowledge of the incidence of medical adverse events (AEs) comes from studies carried out in hospital settings. Little is known about AEs occurring outside hospitals, in spite the fact that most of contacts between patients and health care take place in primary care. Small sample population studies report that 4–49% of the general public have experienced AEs related to their own or ... -
What professional activities do general practitioners find most meaningful? Cross sectional survey of Norwegian general practitioners
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)Health reforms in many countries affect the scope and nature of primary care. General Practitioners (GPs) are expected to spend more time developing public health, preventive health care, coordination of care and teamwork. We aimed to explore which professional activities GPs consider to be meaningful and how they would like to prioritise tasks. In a cross sectional online survey 3,270 GPs were ... -
Human endogenous retroviruses and cancer prevention: evidence and prospects
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)Cancer is a significant and growing problem worldwide. While this increase may, in part, be attributed to increasing longevity, improved case notifications and risk-enhancing lifestyle (such as smoking, diet and obesity), hygiene-related factors resulting in immuno-regulatory failure may also play a major role and call for a revision of vaccination strategies to protect against a range of cancers ... -
Vertebral fractures and self-perceived health in elderly women and men in a population-based cross-sectional study: the Tromsø Study 2007-08
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)Health-related quality of life (HRQL) may be associated with increased mortality in the elderly. The effect of prevalent vertebral fractures on HRQL in elderly women and men is not well described. The purpose of this study was to examine the association between prevalent vertebral fractures and back pain, neck pain, and HRQL in elderly women and men, and to study possible gender differences in the ... -
Active and passive smoking and the risk of myocardial infarction in 24,968 men and women during 11 year of follow-up: the Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)Active smoking is a well-established risk factor for myocardial infarction, but less is known about the impact of passive smoking, and possible sex differences in risk related to passive smoking. We investigated active and passive smoking as risk factors for myocardial infarction in an 11-year follow-up of 11,762 men and 13,206 women included in the Tromsø Study. There were a total of 769 and 453 ... -
Sex differences in mortality of admitted patients with personality disorders in North Norway - a prospective register study.
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)It is well established that patients with serious mental disorders have higher mortality than the general population, yet there are few studies on mortality of both natural and unnatural causes in patients with personality disorders. The aim of this study was to investigate the mortality of in-patients with personality disorder diagnosis in a 27-year follow-up cohort in North Norway, with a special ... -
Prevalence and population structure of Staphylococcus aureus nasal carriage in healthcare workers in a general population. The Tromsø Staph and Skin Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)Healthcare workers (HCWs) may be a reservoir for Staphylococcus aureus transmission to patients. We examined whether HCW status is associated with S. aureus nasal carriage and population structure (spa types) in 1302 women (334 HCWs) and 977 men (71 HCWs) aged 30–69 years participating in the population-based Tromsø Study in 2007–2008. Multivariable logistic regression models were used. While no ... -
Risk of cardiovascular disease? A qualitative study of risk interpretation among patients with high cholesterol
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)Previous studies have shown the importance of paying attention to lay peoples’ interpretations of risk of disease, in order to explain health-related behavior. However, risk interpretations interplay with social context in complex ways. The objective was to explore how asymptomatic patients with high cholesterol interpret risk of cardiovascular disease. Fourteen patients with high cholesterol and ... -
GPs' decision-making - perceiving the patient as a person or a disease
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012)Background: The aim of this study was to analyse the clinical decision making strategies of GPs with regard to the whole range of problems encountered in everyday work. Methods: A prospective questionnaire study was carried through, where 16 General practitioners in Sweden registered consecutively 378 problems in 366 patients. Results: 68.3% of the problems were registered as somatic, 5.8% as ... -
Abdominal aortic aneurysms, or a relatively large diameter of non-aneurysmal aortas, increase total and cardiovascular mortality: the Tromsø study.
(Journal article; Tidsskriftartikkel; Peer reviewed, 2010)Background: In a population-based study in Tromsø, Norway, the authors assessed whether an abdominal aortic aneurysm (AAA) or the maximal infrarenal aortic diameter in a non-aneurismal aorta influence total and cardiovascular disease (CVD) mortality. Methods: A total of 6640 men and women, aged 25–84 years, were included in a 10-year mortality follow-up: 345 subjects with a diagnosed AAA and ... -
The complexity of managing COPD exacerbations: a grounded theory study of European general practice
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)To understand the concerns and challenges faced by general practitioners (GPs) and respiratory physicians about primary care management of acute exacerbations in patients with chronic obstructive pulmonary disease (COPD). 21 focus group discussions (FGDs) were performed in seven countries with a Grounded Theory approach. Each country performed three rounds of FGDs. Primary and secondary care in ... -
Characterization of novel precursor miRNAs using next generation sequencing and prediction of miRNA targets in Atlantic halibut
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)microRNAs (miRNAs) are implicated in regulation of many cellular processes. miRNAs are processed to their mature functional form in a step-wise manner by multiple proteins and cofactors in the nucleus and cytoplasm. Many miRNAs are conserved across vertebrates. Mature miRNAs have recently been characterized in Atlantic halibut (Hippoglossus hippoglossus L.). The aim of this study was to identify and ... -
Identification and cloning of immunogenic Aliivibrio salmonicida Pal-like protein present in profiled outer membrane and secreted subproteome
(Journal article; Tidsskriftartikkel; Peer reviewed, 2011)Aliivibrio salmonicida is the aetiological agent of cold water vibriosis affecting farmed fish species, a disease that today is fully controlled by vaccination. However, the molecular mechanisms behind the successful vaccine are largely unknown. In order to gain insight into the possible mechanisms of A. salmonicida vaccines, we report here the profiles of both the outer membrane and secreted ... -
Marginalisation and cardiovascular disease among rural Sami in Northern Norway: a population-based cross-sectional study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)Like other indigenous peoples, the Sami have been exposed to the huge pressures of colonisation, rapid modernisation and subsequent marginalisation. Previous studies among indigenous peoples show that colonialism, rapid modernisation and marginalisation is accompanied by increased stress, an unhealthy cardiovascular risk factor profile and disease burden. Updated data on the general burden of ... -
A study of the protein kinase MK5's effect on melanoma cell proliferation
(Master thesis; Mastergradsoppgave, 2012-09-14)The mitogen-activated protein kinases (MAPKs) play a crucial role in cellular processes such as proliferation, differentiation, apoptosis, metabolism and motility. Both conventional and atypical MAPKs can phosphorylate other proteins referred to as MAPK- activated protein kinases (MAPKAPK) such as MK5 or p38-regulated /activated protein kinase. Mutations in the MK5 gene have been detected in lung, ... -
Use of Complementary and Alternative Medicine Among Patients: Classification Criteria Determine Level of Use
(Journal article; Tidsskriftartikkel; Peer reviewed, 2008)Background and objectives: Self-reported use of complementary and alternative medicine (CAM) among patients varies widely between studies, possibly because the definition of a CAM user is not comparable. This makes it difficult to compare studies. The aim of this study is to present a six-level model for classifying patients' reported exposure to CAM. Prayer, physical exercise, special diets, ... -
Do cancer patients with a poor prognosis use Complementary and Alternative Medicine more often than others?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2009)Introduction: One reason for patients with cancer to use complementary and alternative medicine (CAM) is that their cancer cannot be cured by conventional therapy. The aim of the present study is to explore whether use of CAM is associated with survival prognosis in long-term survivors of cancer. Materials and methods: Cancer patients who were alive 5 years or more after diagnosis were chosen to ... -
Complementary and Alternative Medicine Use among Norwegian Cancer Survivors: Gender-Specific Prevalence and Associations for Use
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)The associations for CAM use are only occasionally differentiated by gender in populations where both male and female cancer survivors occur. The aim of this study is to describe the prevalence of CAM use in individuals with a previous cancer diagnosis and to investigate gender differences regard to factors associated with use. A total of 12982 men and women filled in a questionnaire with questions ... -
Molecular targets and biological effects of PAX6 in lung cancer
(Master thesis; Mastergradsoppgave, 2013-05-15)Lung cancer is by far the leading cause of cancer-related mortality worldwide regardless of sex, and has a dismal overall 5-year survival rate of approximately 15%. More than 85% of all lung cancers are non-small cell lung cancer (NSCLC), and about 50% of these are adenocarcinomas. Targeted treatment has shown promising results in treating certain types of NSCLC, but the overall survival is still ...
