Vis enkel innførsel

dc.contributor.authorSkhvitaridze, Natia
dc.contributor.authorGamkrelidze, Amiran
dc.contributor.authorManjavidze, Tinatin
dc.contributor.authorBrenn, Tormod Ola
dc.contributor.authorRylander, Karin Charlotta Maria
dc.date.accessioned2024-09-23T08:47:47Z
dc.date.available2024-09-23T08:47:47Z
dc.date.issued2024-02-22
dc.description.abstractBackground Georgia experienced an increase in maternal deaths (MD) during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, which warrants further investigation. This study aimed to assess associations between timing of SARS-CoV-2 infection during pregnancy and MD, post-delivery intensive care unit (ICU) admission, and caesarean section (CS) delivery.<p> <p>Methods We performed a national birth registry-based cohort study of pregnant women who had completed 22 weeks of gestation and delivered between February 28, 2020, and August 31, 2022. The data were linked to coronavirus disease 2019 (COVID-19) testing, vital, and immunization registries. Pregnant women were classified into three groups: confirmed SARS-CoV-2 infection from conception through 31 days before delivery; confirmed infection within 30 days before or at delivery; and women negative for SARS-CoV-2 infection or without any test results (reference group). Multivariable logistic regression was used to calculate the adjusted odds ratios (aORs) and 95% confidence intervals (CIs). <p>Results Among 111,493 pregnant women, 16,751 had confirmed infection during pregnancy, and 7,332 were fully vaccinated against COVID-19 before delivery. Compared to the reference group, those with confirmed infection within 30 days before or at delivery experienced increased odds of MD (aOR: 43.11, 95% CI, 21.99–84.55), post-delivery ICU admission (aOR: 5.20, 95% CI, 4.05–6.67), and CS delivery (aOR: 1.11, 95% CI, 1.03–1.20). <p>Conclusions Pregnant women in Georgia with confirmed SARS-CoV-2 infection within 30 days before or at delivery experienced a considerably higher risk of MD and post-delivery ICU admission and a slightly higher risk for CS delivery. Additionally, the results highlighted that most pregnant women were not vaccinated against COVID-19. These findings should alert stakeholders that adherence to public health preventive measures needs to be improved.en_US
dc.identifier.citationSkhvitaridze, Gamkrelidze, Manjavidze, Brenn, Rylander. SARS-CoV-2 infection during pregnancy and the risk of adverse maternal outcomes in the Republic of Georgia: a national birth registry-based cohort study. BMC Pregnancy and Childbirth. 2024;24(1)
dc.identifier.cristinIDFRIDAID 2260275
dc.identifier.doi10.1186/s12884-024-06329-x
dc.identifier.issn1471-2393
dc.identifier.urihttps://hdl.handle.net/10037/34822
dc.language.isoengen_US
dc.publisherBMCen_US
dc.relation.ispartofSkhvitaridze, N. (2024). Maternal death and maternal morbidity in Georgia. (Doctoral thesis). <a href=https://hdl.handle.net/10037/34961>https://hdl.handle.net/10037/34961</a>.
dc.relation.journalBMC Pregnancy and Childbirth
dc.rights.holderCopyright 2024 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleSARS-CoV-2 infection during pregnancy and the risk of adverse maternal outcomes in the Republic of Georgia: a national birth registry-based cohort studyen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


Tilhørende fil(er)

Thumbnail

Denne innførselen finnes i følgende samling(er)

Vis enkel innførsel

Attribution 4.0 International (CC BY 4.0)
Med mindre det står noe annet, er denne innførselens lisens beskrevet som Attribution 4.0 International (CC BY 4.0)