Transdiagnostic Associations between Anger Hostility and Chemokine Interferon-gamma Inducible Protein 10
Permanent lenke
https://hdl.handle.net/10037/34954Dato
2023-07-17Type
Journal articleTidsskriftartikkel
Peer reviewed
Forfatter
Soløy-Nilsen, Hedda; Nygaard-Odeh, Kristin; Kristiansen, Magnhild Gangsøy; Kvig, Erling Inge; Brekke, Ole Lars; Mollnes, Tom Eirik; Berk, Michael; Reitan, Solveig Klæbo; Øiesvold, TerjeSammendrag
Methods: This was a cross sectional naturalistic study with 132 participants from a general open inpatient psychiatric ward at the Nordland Hospital Trust, Norway. Serum levels of 28 different cytokines were assessed. Psychiatric symptoms the last week were assessed by a self-rating scale (Symptom check list, SCL-90-R) and grouped in defined clusters. Multiple linear regression model was used for statistical analyses of associations between levels of cytokines and symptoms, adjusting for possible confounding factors.
Results: We found a positive association (p = 0.009) between the chemokine interferon-gamma inducible protein 10 (CXCL 10; IP-10) and the anger hostility cluster. No associations were found between the other symptom clusters and cytokines. IP-10 and the anger hostility cluster were positively associated (p = 0.002) in the subgroup of patients using psychotropic medication, not in the subgroup not using psychotropic medication.
Conclusion: Our analyses revealed a significant positive association between the symptom cluster anger hostility in SCL-90-R and the chemokine IP-10 in the subgroup of patients using psychotropic medications.