dc.contributor.author | Hansen, Solrunn | |
dc.contributor.author | Xu, Shanshan | |
dc.contributor.author | Huber, Sandra | |
dc.contributor.author | Alvarez, Marisa Viviana | |
dc.contributor.author | Odland, Jon Øyvind | |
dc.date.accessioned | 2024-10-03T12:19:12Z | |
dc.date.available | 2024-10-03T12:19:12Z | |
dc.date.issued | 2024-01-13 | |
dc.description.abstract | Background: Per- and polyfluoroalkyl substances (PFAS) are a group of synthetic chemicals with potential adverse
health effects. Information concerning PFAS concentrations in relation to pregnancy is scarce in South America
and non-existent in Argentina.
Aim: We aimed to investigate an extended maternal PFAS profile herein serum concentrations in a regional and
global view, source appointment, and determinants in Argentinean women.<p>
<p>Methods: A cross-sectional study with a sampling period from 2011 to 2012 included 689 women from Ushuaia
and Salta in Argentina. Serum samples collected two days postpartum were analyzed by ultra-high pressure
liquid chromatography coupled to electrospray negative ionisation tandem-quadrupole mass-spectrometry.
Principal Component Analysis (PCA) following absolute principal component score-multiple linear regression
(APCS-MLR) was used for PFAS source appointments. Determinants of PFAS were explored through a MLR
approach. A review of previous studies within the same period was conducted to compare with present levels. <p>Results: Argentinean PFAS concentrations were the lowest worldwide, with PFOS (0.74 ng/mL) and PFOA (0.11
ng/mL) as the dominant substances. Detection frequencies largely aligned with the compared studies, indicating
the worldwide PFAS distribution considering the restrictions. The PCA revealed region-specific loading patterns
of two component groups of PFAS, a mixture of replaced and legacy substances in Ushuaia and long-chain in
Salta. This might relate to a mix of non-diet and diet exposure in Ushuaia and diet in Salta. Region, age, lactation,
parity, household members, migration, bottled water, and freshwater fish were among the determinants of
various PFAS.
<p>Conclusion: This is the first study to monitor human PFAS exposure in Argentina. Maternal PFAS concentrations
were the lowest observed worldwide in the same period. Exposure contributions are suggested to be affected by
restrictions and substitutions. Given the limited population-based studies and the emergence of PFAS, it is
essential to conduct further monitoring of PFAS in Argentina and South America. | en_US |
dc.identifier.citation | Hansen, Xu, Huber, Alvarez, Odland. Profile of per- and polyfluoroalkyl substances, source appointment, and determinants in Argentinean postpartum women. Science of the Total Environment. 2024;915 | en_US |
dc.identifier.cristinID | FRIDAID 2245872 | |
dc.identifier.doi | 10.1016/j.scitotenv.2024.170096 | |
dc.identifier.issn | 0048-9697 | |
dc.identifier.issn | 1879-1026 | |
dc.identifier.uri | https://hdl.handle.net/10037/35033 | |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier | en_US |
dc.relation.journal | Science of the Total Environment | |
dc.rights.accessRights | openAccess | en_US |
dc.rights.holder | Copyright 2024 The Author(s) | en_US |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | en_US |
dc.rights | Attribution 4.0 International (CC BY 4.0) | en_US |
dc.title | Profile of per- and polyfluoroalkyl substances, source appointment, and determinants in Argentinean postpartum women | en_US |
dc.type.version | publishedVersion | en_US |
dc.type | Journal article | en_US |
dc.type | Tidsskriftartikkel | en_US |
dc.type | Peer reviewed | en_US |