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dc.contributor.authorLærum, Dan
dc.contributor.authorStrand, Trond-Eirik
dc.contributor.authorBrustugun, Odd Terje
dc.contributor.authorGallefoss, Frode
dc.contributor.authorFalk, Ragnhild Sørum
dc.contributor.authorDurheim, Michael Thomas
dc.contributor.authorFjellbirkeland, Lars
dc.date.accessioned2024-10-14T11:05:46Z
dc.date.available2024-10-14T11:05:46Z
dc.date.issued2024-05-15
dc.description.abstractBackground: Whether sex is an independent prognostic factor in lung cancer survival is the subject of ongoing debate. Both large national registries and single hospital studies have shown conflicting findings. In this study, we explore the impact of sex on lung-cancer-specific survival in an unselected population that is well-characterized with respect to stage and other covariates. Material and methods: All patients diagnosed with lung cancer at a single hospital serving a whole and defined region in Southern Norway during the 10 years 2007–2016 were included. Follow-up data were available for at least 56 months for all patients. Analyses were adjusted for stage, treatment, performance status, smoking, age, histology, epidermal growth factor receptor/anaplastic lymphoma kinase/immunotherapy treatment and period. Differences in lung-cancer-specific survival by sex were explored using restricted mean survival times (RMST).<p> <p>Results: Of the 1,261 patients diagnosed with lung cancer, 596 (47%) were females and 665 (53%) males, with mean ages of 68.5 and 69.5 years, respectively. The observed 5-year lung-cancer-specific survival rate was 27.4% (95% CI 23.7, 31.2) in females and 21.4% (95% CI 18.2, 24.8) in males. However, after adjustment for covariates, no significant differences by sex were observed. The 5-year RMST was 0.9 months shorter (95% CI −2.1, 0.31, p = 0.26) in males compared to females.<p> <p>Interpretation: In this cohort, sex was not associated with a difference in lung-cancer-specific survival after adjusting for clinical and biological factors. Imbalance in stage at diagnosis was the main contributor to the observed difference in lung-cancer-specific survival by sex.en_US
dc.identifier.citationLærum, Strand, Brustugun, Gallefoss, Falk, Durheim, Fjellbirkeland. Evaluation of sex inequity in lung-cancer-specific survival. Acta Oncologica. 2024;63:343-350en_US
dc.identifier.cristinIDFRIDAID 2273908
dc.identifier.doi10.2340/1651-226X.2024.27572
dc.identifier.issn0284-186X
dc.identifier.issn1651-226X
dc.identifier.urihttps://hdl.handle.net/10037/35222
dc.language.isoengen_US
dc.publisherMedical Journals Sweden ABen_US
dc.relation.journalActa Oncologica
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2024 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleEvaluation of sex inequity in lung-cancer-specific survivalen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's license is described as Attribution 4.0 International (CC BY 4.0)