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dc.contributor.authorDuelund-Jakobsen, Jakob
dc.contributor.authorBuntzen, Steen
dc.contributor.authorLundby, Lilli
dc.contributor.authorLaurberg, Søren
dc.contributor.authorSørensen, Michael
dc.contributor.authorRydningen, Mona Birgitte
dc.date.accessioned2024-10-15T07:21:53Z
dc.date.available2024-10-15T07:21:53Z
dc.date.issued2024-03-11
dc.description.abstractAim: Sacral neuromodulation (SNM) is approved for the treatment of faecal incontinence (FI) in a two-stage technique. With standardized implantation, approximately 90% of pa tients undergo successful Stage I operation and proceed to a permanent implant (Stage II). The aim of this work was to explore the feasibility of SNM as a one-stage procedure and report the 24-week efficacy.<p> <p>Method: This study included patients diagnosed with idiopathic FI or FI due to an external anal sphincter defect ≤160° and one or more episodes of FI per week despite maximal conservative therapy. Patients were offered a one-stage procedure if a motor response of the external anal sphincter was achieved in three or more poles with at least one at ≤1.5 mA at lead placement. Patients were followed for 24 weeks. Their evaluation included the Wexner/St Mark's Incontinence Score, Faecal Incontinence Quality of Life score (FIQoL), a visual analogue scale (VAS) for assessing patient satisfaction and a bowel habit diary. <p>Results: Seventy-three patients with a median age of 60 years (interquartile range 50–69 years) completed this prospective study. Episodes of FI were significantly reduced at the 24-week follow-up, from 13 (8–23) at baseline to 2 (0–5) (p-value = 0002). A ≥50% reduction in the number of FI episodes was achieved in 92% of participants. The Wexner score improved significantly from 16 (14–17) at baseline to 9 (5–13) (p-value < 0.001), and the St Mark's score improved significantly from 18 (16–20) to 11 (7–16) (p-value < 0.001). All domains in the FIQoL score and VAS for patient satisfaction improved significantly following the one-stage procedure. <p>Conclusion: A one-stage implantation procedure is feasible in selected patients with FI, significantly improving continence, quality of life and patient satisfaction after 24 weeks of follow-up.en_US
dc.identifier.citationDuelund-Jakobsen, Buntzen, Lundby, Laurberg, Sørensen, Rydningen. One-stage implant in sacral neuromodulation for faecal incontinence – short-term outcome from a prospective study. Colorectal Disease. 2024en_US
dc.identifier.cristinIDFRIDAID 2261995
dc.identifier.doi10.1111/codi.16936
dc.identifier.issn1462-8910
dc.identifier.issn1463-1318
dc.identifier.urihttps://hdl.handle.net/10037/35233
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.journalColorectal Disease
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2024 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleOne-stage implant in sacral neuromodulation for faecal incontinence – short-term outcome from a prospective studyen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Med mindre det står noe annet, er denne innførselens lisens beskrevet som Attribution 4.0 International (CC BY 4.0)