dc.contributor.author | Duelund-Jakobsen, Jakob | |
dc.contributor.author | Buntzen, Steen | |
dc.contributor.author | Lundby, Lilli | |
dc.contributor.author | Laurberg, Søren | |
dc.contributor.author | Sørensen, Michael | |
dc.contributor.author | Rydningen, Mona Birgitte | |
dc.date.accessioned | 2024-10-15T07:21:53Z | |
dc.date.available | 2024-10-15T07:21:53Z | |
dc.date.issued | 2024-03-11 | |
dc.description.abstract | Aim: Sacral neuromodulation (SNM) is approved for the treatment of faecal incontinence
(FI) in a two-stage technique. With standardized implantation, approximately 90% of pa tients undergo successful Stage I operation and proceed to a permanent implant (Stage
II). The aim of this work was to explore the feasibility of SNM as a one-stage procedure
and report the 24-week efficacy.<p>
<p>Method: This study included patients diagnosed with idiopathic FI or FI due to an external anal sphincter defect ≤160° and one or more episodes of FI per week despite
maximal conservative therapy. Patients were offered a one-stage procedure if a motor
response of the external anal sphincter was achieved in three or more poles with at least
one at ≤1.5 mA at lead placement. Patients were followed for 24 weeks. Their evaluation
included the Wexner/St Mark's Incontinence Score, Faecal Incontinence Quality of Life
score (FIQoL), a visual analogue scale (VAS) for assessing patient satisfaction and a bowel
habit diary.
<p>Results: Seventy-three patients with a median age of 60 years (interquartile range
50–69 years) completed this prospective study. Episodes of FI were significantly reduced
at the 24-week follow-up, from 13 (8–23) at baseline to 2 (0–5) (p-value = 0002). A ≥50%
reduction in the number of FI episodes was achieved in 92% of participants. The Wexner
score improved significantly from 16 (14–17) at baseline to 9 (5–13) (p-value < 0.001), and
the St Mark's score improved significantly from 18 (16–20) to 11 (7–16) (p-value < 0.001).
All domains in the FIQoL score and VAS for patient satisfaction improved significantly
following the one-stage procedure.
<p>Conclusion: A one-stage implantation procedure is feasible in selected patients with FI,
significantly improving continence, quality of life and patient satisfaction after 24 weeks
of follow-up. | en_US |
dc.identifier.citation | Duelund-Jakobsen, Buntzen, Lundby, Laurberg, Sørensen, Rydningen. One-stage implant in sacral neuromodulation for faecal incontinence – short-term outcome from a prospective study. Colorectal Disease. 2024 | en_US |
dc.identifier.cristinID | FRIDAID 2261995 | |
dc.identifier.doi | 10.1111/codi.16936 | |
dc.identifier.issn | 1462-8910 | |
dc.identifier.issn | 1463-1318 | |
dc.identifier.uri | https://hdl.handle.net/10037/35233 | |
dc.language.iso | eng | en_US |
dc.publisher | Wiley | en_US |
dc.relation.journal | Colorectal Disease | |
dc.rights.accessRights | openAccess | en_US |
dc.rights.holder | Copyright 2024 The Author(s) | en_US |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | en_US |
dc.rights | Attribution 4.0 International (CC BY 4.0) | en_US |
dc.title | One-stage implant in sacral neuromodulation for faecal incontinence – short-term outcome from a prospective study | en_US |
dc.type.version | publishedVersion | en_US |
dc.type | Journal article | en_US |
dc.type | Tidsskriftartikkel | en_US |
dc.type | Peer reviewed | en_US |