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dc.contributor.authorJohnsen, Pål jarle
dc.contributor.authorTownsend, JP
dc.contributor.authorBøhn, Thomas
dc.contributor.authorSimonsen, Gunnar Skov
dc.contributor.authorSundsfjord, arnfinn
dc.contributor.authorNielsen, Kaare Magne
dc.date.accessioned2012-02-22T07:49:55Z
dc.date.available2012-02-22T07:49:55Z
dc.date.issued2011
dc.description.abstractTo estimate the relative fitness differences between glycopeptide-resistant Enterococcus faecium (GREF) and glycopeptide-susceptible E. faecium (GSEF) from yearly surveillance data on the occurrence of GREF in Danish poultry farm environments. A population genetic model was adapted to retrospectively estimate the biological fitness cost of acquired resistance. Maximization of a likelihood function was used to predict the longitudinal persistence of acquired resistance. Our analysis suggests strong selection against GREF following the 1995 ban on the glycopeptide growth promoter avoparcin. However, parameterizing the model with two selection coefficients suggesting a reduced negative effect of the acquired resistance on bacterial fitness over time significantly improved the fit of the model. Our analyses suggest that the acquired glycopeptide resistance will persist for >25 years. Conclusions Acquired resistance determinants in commensal E. faecium populations in Danish farm environments are likely to persist for decades, even in the absence of glycopeptide use.en
dc.identifier.citationJournal of Antimicrobial Chemotherapy 66(2011) nr. 3 s. 608-610en
dc.identifier.issn0305-7453
dc.identifier.otherFRIDAID 795798
dc.identifier.otherdoi: 10.1093/jac/dkq512
dc.identifier.urihttp://hdl.handle.net/10037/3847
dc.identifier.urnURN:NBN:no-uit_munin_3569
dc.language.isoengen
dc.publisherOxford Journalsen
dc.rights.accessRightsopenAccess
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710::Medical microbiology: 715en
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Medisinsk mikrobiologi: 715en
dc.titleRetrospective evidence for a biological cost of vancomycin resistance determinants in the absence of glycopeptide selective pressuresen
dc.typeJournal articleen
dc.typeTidsskriftartikkelen
dc.typePeer revieweden


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