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dc.contributor.authorChen, Wei
dc.contributor.authorLim, Chi Eung Danforn
dc.contributor.authorKang, Hong-Jun
dc.contributor.authorLiu, Jianping
dc.date.accessioned2012-03-14T10:52:43Z
dc.date.available2012-03-14T10:52:43Z
dc.date.issued2011
dc.description.abstractChinese herbs are thought to be effective for type A H1N1 influenza. Series of Chinese herbs have been authorized recommended by the Chinese government, and until now a number of clinical trials of Chinese herbs for H1N1 influenza have been conducted. However, there is no critically appraised evidence such as systematic reviews or metaanalyses on potential benefits and harms of medicinal herbs for H1N1 influenza to justify their clinical use and their recommendation. CENTRAL, MEDLINE, EMBASE, CBM, CNKI, VIP, China Important Conference Papers Database, China Dissertation Database, and online clinical trial registry websites were searched for published and unpublished randomized controlled trials (RCTs) of Chinese herbs for H1N1 influenza till 31 August, 2011. A total of 26 RCTs were identified and reviewed. Most of the RCTs were of high risk of bias with flawed study design and poor methodological quality. The combination of several Chinese herbal medicines with or without oseltamivir demonstrated positive effect on fever resolution, relief of symptoms, and global effectiveness rate compared to oseltamivir alone. However, only one herbal medicine showed positive effect on viral shedding. Most of the trials did not report adverse events, and the safety of herbal medicines is still uncertain. Some Chinese herbal medicines demonstrated potential positive effect for 2009 type A H1N1 influenza; however, due to the lack of placebo controlled trial and lack of repeated test of the intervention, we could not draw confirmative conclusions on the beneficial effect of Chinese herbs for H1N1 influenza. More rigorous trials are warranted to support their clinical use.en
dc.identifier.citationPLoS ONE (2011) 6(12): e28093.en
dc.identifier.issn1932-6203
dc.identifier.otherFRIDAID 901281
dc.identifier.otherdoi: 10.1371/journal.pone.0028093
dc.identifier.urihttp://hdl.handle.net/10037/3961
dc.identifier.urnURN:NBN:no-uit_munin_3683
dc.language.isoengen
dc.publisherPublic Library of Science (PLoS)en
dc.rights.accessRightsopenAccess
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801en
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801en
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Preventive medicine: 804en
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Forebyggende medisin: 804en
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Health service and health administration research: 806en
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Helsetjeneste- og helseadministrasjonsforskning: 806en
dc.titleChinese Herbal Medicines for the Treatment of Type A H1N1 Influenza : a Systematic Review of Randomized Controlled Trialsen
dc.typeJournal articleen
dc.typeTidsskriftartikkelen
dc.typePeer revieweden


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