Now showing items 1755-1774 of 5495

    • Exploration of 27 plasma immune markers: A cross-sectional comparison of 64 old psychiatric inpatients having unipolar major depression and 18 non-depressed old persons 

      Gaarden, Torfinn Lødøen; Engedal, Knut; Saltyte Benth, Jurate; Larsen, Marianne; Lorentzen, Bernhard; Mollnes, Tom Eirik; Bjølseth, Tor Magne; Castellheim, Albert (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-06-25)
      <p><i>Background</i>: The prevalence of major depression (MD) according to population studies is the same for old (65 years and older) and younger adults. In contrast, an elevated proportion of old MD patients are hospitalized compared to younger adults with MD, indicating a need to expand the characteristics of old inpatients with MD. To illustrate this point, the association between inflammation ...
    • Exploration of characteristics of community pharmacies that may influence the successful outcomes of Stop Smoking Services 

      Mortensen, Kristian (Master thesis; Mastergradsoppgave, 2013-05-20)
      BACKGROUND: National Health Service (NHS) Lothian community pharmacies contracted to deliver the Stop Smoking Service have varying success rates. A clearer understanding of the factors or predictors which may impact on the success of the NHS community pharmacy Stop Smoking Services is required by NHS Lothian Public Health Directorate. AIM:To describe the characteristics of community pharmacies ...
    • Exploring Personality and Readiness to Change in Patients With Substance Use Disorders With and Without ADHD 

      Flores, Lizbett; Ytterstad, Elinor; Lensing, Michael B.; Eisemann, Martin (Journal article; Tidsskriftartikkel; Peer reviewed, 2016)
      <p><i>Objective</i>: To explore personality and readiness to change among substance use disorders (SUD) patients with and without ADHD.</p> <p><i>Method</i>: SUD + ADHD versus SUD − ADHD patients consecutively entering treatment between 2010 and 2012 were compared concerning personality (Temperament and Character Inventory) and readiness to change (Stages of Change Readiness and Treatment Eagerness ...
    • Exploring physical activity and dietary choices among adolescents in Troms County, with focus on a potential association between the two health-related behaviors. A cross-sectional study based on Fit Futures - part of The Tromsø Study 

      Sandvær, Vårin (Master thesis; Mastergradsoppgave, 2013-07-30)
      Increased knowledge about physical activity(PA) and dietary choises could be valuable when preventive measures against overweight are planned and carried out. The main aim of the thesis was therefore to explore PA and dietary choises among adolescents in Troms County, furthermore to investigate if there were an association between these two health-related behaviors. The thesis is a cross-sectional ...
    • Exploring the causal and effect nature of EQ-5D dimensions: an application of confirmatory tetrad analysis and confirmatory factor analysis 

      Gamst-Klaussen, Thor; Gudex, Claire; Olsen, Jan Abel (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-07-31)
      <p><i>Background</i>: The relationship between the various items in an HRQoL instrument is a key aspect of interpreting and understanding preference weights. The aims of this paper were i) to use theoretical models of HRQoL to develop a conceptual framework for causal and effect relationships among the five dimensions of the EQ-5D instrument, and ii) to empirically test this framework.</p> ...
    • Exploring the gender specific association between use of complementary and alternative medicine and alcohol consumption and injuries caused by drinking. The sixth Tromsø study 

      Sivertsen, Kristina (Master thesis; Mastergradsoppgave, 2017-08-25)
      Background: Previous studies have found that the use of complementary and alternative medicine (CAM) is associated with several characteristic, such as female gender, higher education and higher income. However, studies investigating the relationship between alcohol consumption patterns and different CAM approaches have so far been limited. Harmful use of alcohol has detrimental consequences to ...
    • Exploring the in vitro expansion of CD4 T cells. For improved culturing of CD4 T cells linked to FNAIT 

      Hofsten, Susannah von (Master thesis; Mastergradsoppgave, 2018-05-15)
      Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a rare disease that may cause serious bleedings in the fetus or neonate of a woman who has developed antibodies against the fetus’ platelets. Development of FNAIT has been linked to the presence of platelet reactive CD4 T cells that help B cells to develop into antibody producing plasma cells. To be able to conduct research on such T cells, ...
    • Exploring the meaning of a new assistive technology device for older individuals 

      Gramstad, Astrid; Storli, Sissel Lisa; Hamran, Torunn (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)
    • Exploring the overlapping binding sites of ifenprodil and EVT‐101 in GluN2B‐containing NMDA receptors using novel chicken embryo forebrain cultures and molecular modeling 

      Fjelldal, Marthe Fredheim; Freyd, Thibaud; Evenseth, Linn; Sylte, Ingebrigt; Ring, Avi; Paulsen, Ragnhild Elisabeth (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-30)
      N‐methyl‐d‐aspartate receptors (NMDAR) are widely expressed in the brain. GluN2B subunit‐containing NMDARs has recently attracted significant attention as potential pharmacological targets, with emphasis on the functional properties of allosteric antagonists. We used primary cultures from chicken embryo forebrain (E10), expressing native GluN2B‐containing NMDA receptors as a novel model system. ...
    • Exploring the Wnt signaling pathway in schizophrenia and bipolar disorder 

      Hoseth, Eva Zsuzsanna; Krull, Florian; Dieset, Ingrid; Mørch, Ragni Helene; Hope, Sigrun; Gardsjord, Erlend Strand; Steen, Nils Eiel; Melle, Ingrid; Brattbakk, Hans-Richard; Steen, Vidar Martin; Aukrust, Pål; Djurovic, Srdjan; Andreassen, Ole Andreas; Ueland, Thor (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-03-06)
      The Wnt signaling pathway plays a crucial role in neurodevelopment and in regulating the function and structure of the adult nervous system. Schizophrenia (SCZ) and bipolar disorder (BD) are severe mental disorders with evidence of subtle neurodevelopmental, structural and functional neuronal abnormalities. We aimed to elucidate the role of aberrant regulation of the Wnt system in these disorders ...
    • Exploring why and how encounters with the Norwegian health-care system can be considered culturally unsafe by North Sami-speaking patients and relatives: A qualitative study based on 11 interviews 

      Mehus, Grete; Bongo, Berit Andersdatter; Engnes, Janne Isaksen; Moffitt, Pertice (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-09)
      <p><i>Background - </i>Citizens of Norway have free and equal access to healthcare. Nurses are expected to be culturally sensitive and have cultural knowledge in encounters with patients. Culturally safe care is considered both a process and an outcome, evaluated by whether the patients feel safe, empowered and cared for, or not. All patients request equal access to quality care in Norway, also Sami ...
    • Exposure to bacterial products lipopolysaccharide and flagellin and hepatocellular carcinoma: A nested case-control study 

      Fedirko, Veronika; Tran, Hao Quang; Gewirtz, Andrew T.; Stepien, Magdalena; Trichopoulou, Antonia; Aleksandrova, Krasimira; Olsen, Anja; Tjønneland, Anne; Overvad, Kim; Carbonnel, Franck; Boutron-Ruault, Marie-Christine; Severi, Gianluca; Kühn, Tilman; Kaaks, Rudolf; Boeing, Heiner; Bamia, Christina; Lagiou, Pagona; Grioni, Sara; Panico, Salvatore; Palli, Domenico; Tumino, Rosario; Naccarati, Alessio; Peeters, Petra H.; Bueno-De-Mesquita, Hendrik Bastiaan; Weiderpass, Elisabete; Castaño, José María Huerta; Barricarte, Aurelio; Sánchez, María-José; Dorronsoro, Miren; Quirós, José Ramón; Agudo, Antonio; Sjöberg, Klas; Ohlsson, Bodil; Hemmingsson, Oskar; Werner, Mårten; Bradbury, Kathryn E.; Khaw, Kay-Tee; Wareham, Nick; Tsilidis, Konstantinos K.; Aune, Dagfinn; Scalbert, Augustin; Romieu, Isabelle; Riboli, Elio; Jenab, Mazda (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-04-04)
      Background:<br>Leakage of bacterial products across the gut barrier may play a role in liver diseases which often precede the development of liver cancer. However, human studies, particularly from prospective settings, are lacking.<br>Methods:<br>We used a case-control study design nested within a large prospective cohort to assess the association between circulating levels of anti-lipopolysaccharide ...
    • Exposure to community violence, psychopathology, and personality traits in Russian youth. 

      Koposov, Roman A; Ruchkin, Vladislav (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Previous research with the US inner-city youth demonstrated the hazardous effects of community violence exposure. It remains unclear, however, whether these findings are generalizable to other cultures and populations. Furthermore, the role of factors influencing the processing of traumatic events such as personality has not been investigated. Two groups of Russian adolescents (community youth (N ...
    • Expression and activity of NADPH oxidases (NOX) and the ROS-mediated effects on γ-Glutamyltransferase (GGT) expression in cancer cells 

      Ravuri, Chandra Sekhar (Doctoral thesis; Doktorgradsavhandling, 2010-12-10)
      Cancer cells with the ability to metastasize have also an ability to adapt and survive in new surroundings. This is connected to their ability to alter the balance between and the level of oxidants and antioxidants within the cell. To understand how cancer cells do this, a panel of cancer cells were examined with respect to genes that can affect the oxidant production. These cells had been isolated ...
    • Expression and function of the miR-143/145 cluster in vitro and in vivo in human breast cancer 

      Johannessen, Charles; Moi, Line; Kiselev, Yury; Pedersen, Mona Irene; Dalen, Stig Manfred; Braaten, Tonje; Busund, Lill-Tove (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-10-26)
      MicroRNAs (miRNAs) are small non-coding RNAs that function as post-transcriptional regulators of gene expression and are dysregulated in cancer. Studies of miRNAs to explore their potential as diagnostic and prognostic markers are of great scientific interest. Here, we investigate the functional properties and expression of the miR-143/145 cluster in breast cancer (BC) in vitro and in vivo. The ER ...
    • Expression and functional properties of selected miRNAs in human cancer tissue and cancer cell lines 

      Johannessen, Charles Walquist (Doctoral thesis; Doktorgradsavhandling, 2019-03-01)
      MicroRNAs (miRNAs) are small non-coding RNAs (ncRNAs) involved in the regulation of gene expression, and they are often seen dysregulated in cancer. For this reason, it is of great scientific interest to study these ncRNAs to better understand their distribution in human tissues and their mode of function. Based on a comprehensive miRNA microarray from 108 breast cancers in the Norwegian Woman and ...
    • Expression of adenylyl cyclase subtypes in endocrine pancreatic cell lines 

      Krum-Hansen, Sanda (Master thesis; Mastergradsoppgave, 2003-09)
    • Expression of G-Protein βγ Subunits in Endocrine Pancreatic cell Lines 

      Baug, Therese (Master thesis; Mastergradsoppgave, 2004-09)
    • The expression of miR-21 in prostate cancer measured by in situ hybridization and its relevance as a diagnostic biomarker 

      Melbø-Jørgensen, Christian Nordahl (Master thesis; Mastergradsoppgave, 2012-12-15)
      Background: Micro RNAs (miRNA) are a novel class of molecular regulators that have gained considerable attention in cancer research. Multiple studies in recent time have reported altered miRNA regulation in most cancers by deregulating of oncogenes and tumour suppressor genes. Additionally, certain tumours are represented by specific miRNA expression files. Prostate cancer is a markedly heterogeneous ...
    • Expression of phosphatase of regenerating liver (PRL)-3, is independently associated with biochemical failure, clinical failure and death in prostate cancer 

      Andersen, Sigve; Richardsen, Elin; Rakaee, Mehrdad; Bertilsson, Helena; Bremnes, Roy; Børset, Magne; Busund, Lill-Tove; Slørdahl, Tobias (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-11-30)
      Background: Prostate cancer (PC) stratification needs new prognostic tools to reduce overtreatment. Phosphatase of regenerating liver (PRL-3) is a phosphatase found at high levels in several cancer types, where its expression is associated with survival. A recent PC cell line study has shown it to be involved in PC growth and migration. <br>Methods: We used a monoclonal antibody to evaluate ...