<b>Background</b> <br> Group IVA cytosolic phospholipase A2 (cPLA2α) plays an important role in tumorigenesis and angiogenesis. It is overexpressed in basal-like breast cancer (BLBC), which is aggressive and usually triple-negative, making it unresponsive to current targeted therapies. Here, we evaluated the anti-angiogenic effects of a specific cPLA2α inhibitor, AVX235, in a patient-derived ...

Introduction: Consumption of antibacterials in children follows seasonal cycles, and time to first treatment depends on birth season. The aim of this study was to describe dispensing rate, one-year periodic prevalence, and age at first prescription in children aged 0-2 years in Norway. Methods: We used data from the Norwegian prescription database and included all dispensed prescriptions on systemic ...

To date the effectiveness of antibiotics is undermined by microbial resistance, threatening public health worldwide. Enhancing the efficacy of the current antibiotic arsenal is an alternative strategy. The administration of antimicrobials encapsulated in nanocarriers, such as liposomes, is considered a viable option, though with some drawbacks related to limited affinity between conventional liposomes ...

Norwegian health authorities have a goal to reduce the total antibiotic use by 30% by 2020. Studies have shown that dentists contribute to about 8% of the total antibiotic consumption in Norway, which emphasizes the role of dentists to achieve a reduction in the use of antibiotics in the society. The antibiotic prescription pattern among Norwegian dentists from 2010 until 2016 have been mapped and ...

Rationale: Antibiotic resistance compromises achievements of modern medicine and is a major threat to the society. The oral cavity has the distinct microbial community that serves as a reservoir for determinants of antibiotic resistance. Tet(M) gene is abundant in bacteria residing in the oral cavity and is often identified in oral specimens. Absolute quantification of resistance genes copies allows ...

<i>Klebsiella</i> spp. are a major cause of both nosocomial and community acquired infections, with <i>K. pneumoniae</i> being responsible for most human infections. Although <i>Klebsiella</i> spp. are present in a variety of environments, their distribution in the sea and the associated antibiotic resistance is largely unknown. In order to examine prevalence of <i>K. pneumoniae</i> and related ...

Background: Appendicitis is one of the most common causes of acute abdomen. Uncomplicated appendicitis is as an infamed appendix without perforation, gangrene or abscess formation. Recent trials show that one can safely treat uncomplicated appendicitis with antibiotics, given patient approval and appropriate follow-up. A recent study has also indicated no diference between antibiotic treatment ...

Prescriptions of antibiotics in Norway, and the effect of antibiotics on bacteria were investigated. The aim was to describe the consumption of antibiotics through prescriptions to patients and address how antibiotics can favour bacterial resistance. Several methods were applied, multivariate statistics, quantile regression and mathematical modelling of experimental conditions aided in the investigations. ...

OBJECTIVES - We aimed to study whether national and local antibiotic stewardship projects have reduced the antibiotic use in newborns and to monitor potential changes in adverse outcomes.<p> <p>METHODS - In a nationwide, population-based study from Norway, we included all hospital live births from 34 weeks' gestation (n = 282 046) during 2015 to 2019. The primary outcome was the proportion of ...

The main objective of this thesis was to systematically review potential side effects of antibiotic therapy in neonates and to study the gut microbiota composition of preterm infants receiving probiotic prophylaxis. This thesis includes two systemic reviews, a prospective longitudinal multi-centre trial investigating the gut microbiota in preterm infants receiving probiotics compared to preterm ...