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Identification of N-terminal and C-terminal peptides in proteomics
(Master thesis; Mastergradsoppgave, 2018-05-15)Background: Identifying modifications made to terminal parts of proteins are very useful in understanding diseases and other out of the ordinary biological states. This thesis has focused on developing methods for enriching N-terminal and C-terminal peptides from a complex protein mixture, so that analysis of these samples can give better, more comprehensive and more reproducible results. -
Identification of novel roles and new modes of regulation for the atypical MAP kinases ERK3 and ERK4
(Doctoral thesis; Doktorgradsavhandling, 2015-11-13)The atypical MAP kinases ERK3 and ERK4 are the main characters in this study. ERK3 and ERK4 were for long considered as orphan proteins without known upstream activators. However, in 2011 two studies had detected that group I p-21 protein activated kinase (PAKs) can constitutively phosphorylate ERK3 and ERK4 in their activation loop. The only well-characterized substrate for ERK3 and ERK4 at that ... -
Identification of novel serotonin transporter compounds by virtual Screening
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014-02-12)The serotonin (5-hydroxytryptamine, 5-HT) transporter (SERT) plays an essential role in the termination of serotonergic neurotransmission by removing 5-HT from the synaptic cleft into the presynaptic neuron. It is also of pharmacological importance being targeted by antidepressants and psychostimulant drugs. Here, five commercial databases containing approximately 3.24 million drug-like compounds ... -
Identification of p62/SQSTM1 as a component of non-canonical Wnt VANGL2-JNK signalling in breast cancer
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-01-12)The non-canonical Wnt/planar cell polarity (Wnt/PCP) pathway plays a crucial role in embryonic development. Recent work has linked defects of this pathway to breast cancer aggressiveness and proposed Wnt/PCP signalling as a therapeutic target. Here we show that the archetypal Wnt/PCP protein VANGL2 is overexpressed in basal breast cancers, associated with poor prognosis and implicated in tumour ... -
Identification of protein interaction candidates for the GOLD domain of FYCO1
(Master thesis; Mastergradsoppgave, 2016-05-27)Autophagy is an evolutionary conserved degradative pathway, where damaged or surplus cytosolic components are sequestered into double membrane vesicles, autophagosomes, which become degraded through the lysosomal system. The autophagy is a dynamic process, which is depended of transport of autophagosomes along microtubule, to become degraded by lysosomes. One of the proteins involved in this transport ... -
Identification of surface proteins in a clinical Staphylococcus haemolyticus isolate by bacterial surface shaving
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-07)<p><i>Background - </i>The skin commensal <i>Staphylococcus haemolyticus</i> is an emerging nosocomial pathogen. Despite its clinical relevance, published information about <i>S. haemolyticus</i> virulence factors is scarce. In this study, the adhesive and biofilm forming properties of ten clinical and ten commensal <i>S. haemolyticus</i> strains were examined using standard adhesion and biofilm ... -
Identification of VIM-2-producing Pseudomonas aeruginosa from Tanzania is associated with sequence types 244 and 640 and the location of blaVIM-2 in a TniC integron
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014) -
Identification, isolation and characterisation of scavenging endothelial cells in placenta
(Master thesis; Mastergradsoppgave, 2014-05-15)Haemopoiesis occurs in the BM, where haemopoietic stem cells (HSC) reside in a three-dimensional “niche” and give rise to the millions of circulating blood cells required everyday of life. The precise regulation of this immense task occurs by interaction of HSC with other BM cells and extracellular matrix molecules. In addition, the BM vasculature has also now been identified as a key HSC regulator. ... -
Identification, molecular epidemiology, and antibiotic resistance characterization of Acinetobacter spp. clinical isolates
(Doctoral thesis; Doktorgradsavhandling, 2011-09-02) -
Identifisering av antistoffer mot blodplatespesifikke antigener ved hjelp av MAIPA-metode i en cohort av 196 gravide kvinner fra Egypt
(Master thesis; Mastergradsoppgave, 2007-10-01)Som del av blodplatenes cellemembran inngår et antall glykoproteiner som medierer blodplatenes celle-celle-interaksjoner. Blodplatespesifikke alloantigen (Human platelet antigen, HPA) kan føre til immunisering og dannelse av alloantistoffer når mennesker som selv ikke utrykker disse molekylene på overflaten av sine blodplater, blir eksponert for dem. Neonatal alloimmune trombocytopeni (NAIT) er en ... -
Identifisering av en gruppe glykosyltransferaser som mulige målgener for transkripsjonsfaktoren Pax6
(Master thesis; Mastergradsoppgave, 2009-11-09)Det har vært stadig mer forskning på rollen av glykosylering i utvikling av sykdommer i de siste tiårene. Glykosylering av proteiner er en prosess hvor karbohydrat grupper overføres til et protein ved hjelp av glykosyltransferaser. Denne prosessen er nødvendig for riktig folding av proteiner som gir riktig funksjon til ulike proteiner. Endringer i glykosylering av proteiner har vist å ha sammenheng ... -
Identifisering av PAX- og MMP-uttrykk i tre prostatakreft-cellelinjer
(Master thesis; Mastergradsoppgave, 2009-05-20)Invasjon og metastasering er den vanligste årsaken til død hos kreftpasienter og dermed et alvorlig klinisk problem. Det er derfor viktig å forske på dette området for å finne mekanismene bak disse prosessene. Matriks metalloproteinaser (MMPer) er overuttrykt i flere kreftformer. PAX6 er en transkripsjonsfaktor som er vist å regulere matriks metalloproteinase 2 og 9 (MMP-2 og MMP-9) i henholdsvis ... -
Identifisering og fenotyping av invariante NKT-celler
(Master thesis; Mastergradsoppgave, 2009-09-15)NKT-cellene utgjør en liten gruppe av det totale T-celleantall og uttrykker overflatemolekyler karakteristisk for både T- og NK-celler. De er aktive i en rekke ulike immunologiske funksjo-ner. Blant annet kan disse cellene produsere store mengder cytokiner, både pro- og antiin-flammatoriske, og de kan indusere celledød ved direkte cytolytisk aktivitet på andre celler som tumorceller og infiserte ... -
Identifying and correcting epigenetics measurements for systematic sources of variation
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-03-21)<i>Background</i>: Methylation measures quantified by microarray techniques can be affected by systematic variation due to the technical processing of samples, which may compromise the accuracy of the measurement process and contribute to bias the estimate of the association under investigation. The quantification of the contribution of the systematic source of variation is challenging in datasets ... -
Identifying and measuring patient harms. A study of measuring adverse events in hospitalised patients by the Global Trigger Tool record review method
(Doctoral thesis; Doktorgradsavhandling, 2019-05-24)Patient harms, or adverse events which is the term used in this PhD thesis, is a global health problem. The Global Trigger Tool (GTT) is a widely used method to identify and measure adverse events (AEs). The method involves reviewers searching for triggers (situations) in randomly selected medical records and subsequently identifying AEs. However, the method is criticized due to the time used by ... -
Identifying and treating predictors of psychotic symptoms - How findings from Experience Sampling research can help to improve the treatment of psychosis and the prediction of relapse
(Doctoral thesis; Doktorgradsavhandling, 2021-06-10)The present thesis aims at using insights from ESM studies (i.e., frequent ecologically valid self-reports for approximately one week) to improve the treatment and the prediction psychotic symptoms. ESM indicates that warning signs, such as negative affect, worrying, sleep problems, or aberrant salience precede rapidly fluctuating psychotic symptoms throughout the day. Assuming underlying causal ... -
Identifying anti-TNF response biomarkers in ulcerative colitis using a diffusion-based signalling model
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-18)<p><i>Motivation:</i> Resistance to anti-TNF therapy in subgroups of ulcerative colitis (UC) patients is a major challenge and incurs significant treatment costs. Identification of patients at risk of nonresponse to anti-TNF is of major clinical importance. To date, no quantitative computational framework exists to develop a complex biomarker for the prognosis of UC treatment. Modelling patient-wise ... -
Identifying decisions in optometry: A validation study of the decision identification and classification taxonomy for use in medicine (DICTUM) in optometric consultations
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-18)<i>Objective</i> - The aim of this study was to assess the validity and reliability of the Decision Identification and Classification Taxonomy for Use in Medicine (DICTUM) applied to optometry, to compare decisions in medical and optometric consultations, and to describe decisions in optometry. <p> <p><i>Methods</i> - The study had a cross-sectional design. Data was collected from January to ... -
Identifying eating habits in Finnish children: A cross-sectional study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-15)<p><i>Background - </i>We aimed to identify different eating habits among Finnish children and to evaluate their association with meal patterns, breakfast consumption, and socio-demographic characteristics in a large, nationwide cohort of children. <p><i>Methods - </i>We evaluated 10,569 children aged 9–14 years into the Finnish Health in Teens cohort in a cross-sectional design. The hierarchical ... -
Identifying Measures Used for Assessing Quality of YouTube Videos with Patient Health Information: A Review of Current Literature
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)Background: Recent publications on YouTube have advocated its potential for patient education. However, a reliable description of what could be considered quality information for patient education on YouTube is missing. Objective: To identify topics associated with the concept of quality information for patient education on YouTube in the scientific literature. Methods: A literature review was ...
