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In Home we trust. An ethnographic study of mental health and the use of traditional medicine in a North Norwegian community
(Doctoral thesis; Doktorgradsavhandling, 2019-05-24)Traditional healing practices used when faced with illness or crisis, exist in many North Norwegian communities. Northern Troms has a historical multi-ethnicity of Sami, Kven and Norwegian. The notion of culture appears ambivalent and ambiguous, particularly concerning the Sami identity, but cultural diversity is nevertheless manifested through the use of traditional healing practices such as reading. ... -
In HPA 1a-immunized women the decrease in anti-HPA 1a antibody level during pregnancy is not associated with anti-idiotypic antibodies
(Journal article; Tidsskriftartikkel, 2009) -
In need of percutaneous coronary intervention in an arctic setting– patients’ experience of safety and quality of care: a qualitative study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-29)Patients with coronary heart disease need timely treatment for survival and optimum prognosis. There is limited research exploring patients’ experience regarding distance to percutaneous coronary intervention. The aim was to explore patients’ experiences of aspects contributing to safety and quality of care regarding health services following percutaneous coronary intervention in Northern Norway. A ... -
In plastico: laboratory material newness affects growth and reproduction of Daphnia magna reared in 50-ml polypropylene tubes
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-04-20)Plastic laboratory materials are found to affect vital parameters of the waterflea Daphnia magna. The main responsible factor is defined as “newness” of the materials. Juvenile D. magna were raised individually in; a) new laboratory-standard 50 ml polypropylene tubes, and; b) identical tubes which had been washed and aerated for several weeks. Newness had significant effects on growth and fecundity ... -
In search of a common currency: A comparison of seven EQ‐5D‐5L value sets
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-10-24)The recently published EQ‐5D‐5L value sets from Canada, England, Japan, Korea, the Netherlands, Spain, and Uruguay are compared with an aim to identify any similarities in preference pattern. We identify some striking similarities for Canada, England, the Netherlands, and Spain in terms of (a) the relative importance of the 5 dimensions; (b) the relative utility decrements across the 5 levels; and ... -
In Silico Methods for the Discovery of Orthosteric GABAB Receptor Compounds
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-07)The GABA<sub>B</sub> receptor (GABA<sub>B</sub>-R) is a heterodimeric class C G protein-coupled receptor comprised of the GABA<sub>B1a/b</sub> and GABA<sub>B2</sub> subunits. The endogenous orthosteric agonist γ-amino-butyric acid (GABA) binds within the extracellular Venus flytrap (VFT) domain of the GABA<sub>B1a/b</sub> subunit. The receptor is associated with numerous neurological and ... -
In silico screening for GAT-3 inhibitors
(Master thesis; Mastergradsoppgave, 2017-05-15)ϒ-aminobutyric acid (GABA) is the main inhibitory neurotransmitter of the central nervous system (CNS). GABA exert is function by binding to three different receptor subtypes, the GABAA, GABAB and GABAC receptor. The GABA level in different brain regions are regulated by four GABA transporters (GATs); GAT-1, GAT-2, GAT-3 and BGT-1. GAT-3 is located in glial cells that is controlling GABA function ... -
In silico site-directed mutagenesis of the Daphnia magna ecdysone receptor identifies critical amino acids for species-specific and inter-species differences in agonist binding
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-04)Molting is an essential process in the life cycle of arthropods and is regulated by complex neuroendocrine pathways where activation of the ecdysone receptor (EcR) plays a major role. The EcR forms a non-covalent heterodimer with the ultraspiracle protein (USP) when activated by endogenous ecdysteroids, but can also be activated by several insecticides and other environmental chemicals. Environmental ... -
In situ simulation training strengthened bachelor of nursing students’ experienced learning and development process– a qualitative study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-02-15)Background In advanced clinical learning labs on campus, high-fidelity simulation has become an essential educational approach in the Bachelor of Nursing Education programme. However, simulation while in clinical placement, in situ, is rarely used in Bachelor of Nursing Education. The aim of the present study was to explore how in situ simulation training at a surgical hospital ward, according ... -
In the Blink of an Eye: Investigating the Role of Awareness in Fear Responding by Measuring the Latency of Startle Potentiation
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012)The latency of startle reflex potentiation may shed light on the aware and unaware processes underlying associative learning, especially associative fear learning. We review research suggesting that single-cue delay classical conditioning is independent of awareness of the contingency between the conditioned stimulus (CS) and the unconditioned stimulus (US). Moreover, we discuss research that argues ... -
In utero exposure to endocrine disrupting chemicals, micro-RNA profiles, and fetal growth: a pilot study protocol
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-05)<i>Background</i>: The developing fetus is particularly vulnerable to the effects of endocrine disrupting chemicals (EDCs). Molecular fingerprints of EDCs can be identified via microRNA (miRNA) expression profiles and may be etiologically implicated in the developmental origin of disease (DOHaD).<p> <p><i>Methods/design</i>: This pilot study includes pregnant women at high risk (smoking at ... -
In Vitro and in Silico Competitive Binding of Brominated Polyphenyl Ether Contaminants with Human and Gull Thyroid Hormone Transport Proteins
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-12-28)Tetradecabromo-1,4-diphenoxybenzene (TeDB-DiPhOBz) is a highly brominated additive flame retardant (FR). Debrominated photodegradates of TeDBDiPhOBz are hydroxylated <i>in vitro</i> in liver microsomal assays based on herring gulls (<i>Larus argentatus</i>), including one metabolite identified as 4<i>″</i>-OH-2,2<i>′</i>,2<i>″</i>,4-tetrabromo-DiPhOBz. Chemically related methoxylated tetra- ... -
In vitro Candida albicans biofilm formation on different titanium surface topographies
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-09)<i>Objectives</i> - To investigate if differences in titanium implant surface topography influence <i>Candida albicans</i> biofilm formation.<p> <p><i>Materials and Methods</i> - Titanium discs were prepared and characterized using a profilometer: Group A (<i>R</i><sub>a</sub> 0.15 µm, smooth), Group B (<i>R</i> <sub>a</sub> 0.64 µm, minimally rough) and Group C (<i>R</i> <sub>a</sub> 1.3 µm, ... -
In vitro chondrogenic potency of surplus chondrocytes from autologous transplantation procedures does not predict short-term clinical outcomes
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-10)<p><i>Background</i>: Autologous chondrocyte implantation (ACI) has been used over the last two decades to treat focal cartilage lesions aiming to delay or prevent the onset of osteoarthritis; however, some patients do not respond adequately to the procedure. A number of biomarkers that can forecast the clinical potency of the cells have been proposed, but evidence for the relationship between in ... -
In vitro effects of alcohol and oxidative stress on sperm cell motility and viability
(Master thesis; Mastergradsoppgave, 2020-08-28)The deteriorating semen quality is one of the increasing problems of male reproductive health worldwide and the exact cause of this has not been fully understood yet. Many stress factors may affect semen quality such as sperm cell motility and viability and thus impair the fertilization outcome. Among the different stress factors, alcohol can inhibit steroidogenesis, suppresses LH release from the ... -
In vitro fertilisering Tromsø : utvikling av et blastocystregime og resultater i to karakteristiske perioder
(Master thesis; Mastergradsoppgave, 2010-09)Bakgrunn: In vitro fertiliseringsklinikken ved Universitetssykehuset i Nord Norge har vært sterkt delaktig i utviklingen av et regime til bruk i klinisk in vitro fertilisering som går ut på å dyrke embryo i langtidskultur i fem dager til blastocyster. Dette for å selektere de mest levedyktige embryoene for tilbakeføring ved å observere hvilke embryoer som utvikler seg best og ekskludere de som ... -
In vitro generation of functional liver organoid-like structures using adult human cells
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-10-21)In this study we used differentiated adult human upcyte1 cells for the in vitro generation of liver organoids. Upcyte1 cells are genetically engineered cell strains derived from primary human cells by lenti-viral transduction of genes or gene combinations inducing transient proliferation capacity (upcyte1 process). Proliferating upcyte1 cells undergo a finite number of cell divisions, i.e., ... -
In vitro host range, multiplication and virion forms of recombinant viruses obtained from co-infection in vitro with a vaccinia-vectored influenza vaccine and a naturally occurring cowpox virus isolate
(Journal article; Tidsskriftartikkel; Peer reviewed, 2009-05-12)Background: Poxvirus-vectored vaccines against infectious diseases and cancer are currently under development. We hypothesized that the extensive use of poxvirus-vectored vaccine in future might result in co-infection and recombination between the vaccine virus and naturally occurring poxviruses, resulting in hybrid viruses with unpredictable characteristics. Previously, we confirmed that ... -
In vitro micro-CT analyse av demineraliseringslesjoner på emaljeoverflaten
(Mastergradsoppgave; Master thesis, 2020-05-20)Målsetting: Målet med dette masterforsøket er å danne demineraliseringslesjoner som ligner på initialkaries ved hjelp av 4 ulike syreløsninger på emaljeoverflaten in vitro, og deretter sammenlikne bildene utfra de diagnostiske kriteriene, definert under, for å se hvilken som gir det beste resultatet. Metode: 40 tenner ble samlet inn fra UTK og TkNN, hvor deretter 12 tenner ble randomisert valgt ut ... -
In vitro permeation models for healthy and compromised skin: The Phospholipid Vesicle-based Permeation Assay (PVPA) for skin applications
(Doctoral thesis; Doktorgradsavhandling, 2015-03-20)In vitro models with the ability to estimate drug penetration through healthy and compromised skin may reduce animal testing of drugs and cosmetics to a minimum. The phospholipid vesicle based permeation assay (PVPA) is based on a tight barrier composed of liposomes mimicking cells. It was originally made to mimic the intestinal epithelial barrier and in this project further developed to mimic the ...
