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    • Intracellular gelatinolytic activity in mouse tissues 

      Solli, Ann Iren (Master thesis; Mastergradsoppgave, 2011-09-12)
      Matrix metalloproteinases have traditionally been thought to act only extracellulary. However, increasing evidence has revealed intracellular localization as well as several alternative substrates and novel biological roles for these proteinases. The aims of this master thesis were to map intracellular localization of MMP-2 and MMP-9 in different tissues from mouse, determine if detected enzymes ...

    • Intracellular MMP-2 Activity in Skeletal Muscle is Associated with Type II Fibers 

      Hadler-Olsen, Elin Synnøve; Solli, Ann Iren; Hafstad, Anne Dragøy; Winberg, Jan-Olof; Uhlin-Hansen, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-09-29)
      Matrix metalloproteinase 2 (MMP-2) is a proteolytic enzyme implicated in motility, differentiation, and regeneration of skeletal muscle fibers through processing of extracellular substrates. Although MMP-2 has been found to be localized intracellularly in cardiomyocytes where the enzyme is thought to contribute to post-ischemic loss of contractility, little is known about intracellular MMP-2 activity ...

    • Intracellular Transposition and Capture of Mobile Genetic Elements following Intercellular Conjugation of Multidrug Resistance Conjugative Plasmids from Clinical Enterobacteriaceae Isolates 

      Tansirichaiya, Supathep; Goodman, Richard N.; Guo, Xinyu; Bulgasim, Issra; Samuelsen, Ørjan; Al-Haroni, Mohammed; Roberts, Adam P. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-19)
      Mobile genetic elements (MGEs) are often associated with antimicrobial resistance genes (ARGs). They are responsible for intracellular transposition between different replicons and intercellular conjugation and are therefore important agents of ARG dissemination. Detection and characterization of functional MGEs, especially in clinical isolates, would increase our understanding of the underlying ...

    • Intrakranielle gliomer hos personer over 15 år i Nord-Norge i perioden 1986-2001. 

      Bjarghov, Steinar; Stølen, Stian Bergseng (Master thesis; Mastergradsoppgave, 2002-08-30)

    • Intramuscular uptake of tranexamic acid during haemorrhagic shock in a swine model 

      Bakke, Håkon Kvåle; Fuskevåg, Ole Martin; Nielsen, Erik Waage; Dietrichs, Erik Sveberg (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-18)
      Background: Tranexamic acid (TXA) reduce mortality in bleeding trauma patients, with greater efect if administered early. Serum concentrations above 10 µg/mL are considered sufcient to inhibit fbrinolysis. Normally administered intravenously (i.v.), TXA can also be administered intramuscularly (i.m.). This could be advantageous in low resource and military settings, if sufcient serum concentrations ...

    • Intraoperative swept-source OCT–based corneal topography for measurement and analysis of stromal surface after epithelial removal 

      Zhou, Wen; Reinstein, Dan Z.; Archer, Timothy J.; Chen, Xiangjun; Utheim, Tor Paaske; Feng, Yue; Stojanovic, Aleksandar (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-01)
      <p>PURPOSE: To assess intraoperative stromal topography measurements using swept-source optical coherence tomography (OCT)–based topography/tomography after epithelial removal and to analyze the epithelial contribution to the corneal topography and optics. <p>METHODS: This was a prospective series of 22 eyes of 19 patients referred to receive phototherapeutic keratotomy (PTK) for treatment of ...

    • Intraregional hospital outbreak of OXA-244-producing Escherichia coli ST38 in Norway, 2020 

      Lindemann, Paul Christoffer; Pedersen, Torunn Annie; Oma, Dorthea Hagen; Janice, Jessin; Grøvan, Fredrik; Chedid, Ghantous Milad; Hafne, Liv Jorunn; Josefsen, Ellen Haldis; Kacelnik, Oliver; Sundsfjord, Arnfinn; Samuelsen, Ørjan (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-06)
      Infections with OXA-244-carbapenemase-producing Escherichia coli with sequence type (ST)38 have recently increased in Europe. Due to its low-level activity against carbapenems, OXA-244 can be difficult to detect. Previous assessments have not revealed a clear source and route of transmission for OXA-244-producing E. coli, but there are indications of non-healthcare related sources and community ...

    • Intrathoracic Breast Transposition: A New Method in the Treatment of Bronchopleural Fistula and Empyema 

      de Weerd, Louis; Endresen, Petter Cappelen; Numan, Anmar; Weum, Sven (Journal article; Tidsskriftartikkel; Peer reviewed, 2019)
      A bronchopleural fistula (BF) is a life-threatening complication. Optimal management of a BF is still debated although surgery remains the preferred treatment. Usually, the fistula is a result of inadequate healing at the bronchial stump after pneumonectomy. Successful closure of a BF after pneumonectomy depends on evacuation of empyema, coverage of the suture line after fistula closure with ...

    • Intrauterine progestin therapy as a new approach to premalignant endometrial polyps: A prospective observational study 

      Sletten, Elise Thoresen; Arnes, Marit; Vereide, Anne Beate; Ørbo, Anne (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09)
      Background/Aim: Endometrial hyperplastic polyps (EHP) may progress to endometrial carcinoma (EC) if left untreated. We aimed to prospectively investigate the efficacy of the low-dose levonorgestrel intrauterine system (LNG-IUS) as therapy for EHP with malignant potential. Patients and Methods: In total, 37 women with EHP underwent therapy with LNG-IUS containing 13.5 mg levonorgestrel for six months ...

    • Intravenous thrombolytic treatment and endovascular thrombectomy for ischaemic wake-up stroke 

      Roaldsen, Melinda Berg; Lindekleiv, Haakon; Mathiesen, Ellisiv B. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-01)
      <b><p>Background</b> About one in five strokes occur during sleep (wake-up stroke). People with wake-up strokes have previously been considered to be ineligiblefor thrombolytic treatment because the time of stroke onset is unknown. However, recent studies suggest benefit from recanalisationtherapies in selected patients. <b><p>Objectives</b> To assess the effects of intravenous thrombolysis ...

    • Intravenøs ketamin for behandlingsresistent depresjon: Et scoping review 

      Lilleng, Tora; Forfang, Marie Charlotte (Mastergradsoppgave; Master thesis, 2022-12-12)
      Bakgrunn: Depresjon er blant de mest prevalente sykdommene i vestlige land. Flere av pasienter med depressive lidelser opplever ikke bedring av tilgjengelige behandlinger, og betegnes som behandlingsresistente. Lave doser intravenøs ketamin har vist å gi rask antidepressiv effekt kort tid etter infusjon, og det publiseres et stigende antall studier om ketamins virkning. Vi gjennomførte et scoping ...

    • Intra‐arterial blood pressure traits during and after heavy resistance exercise in healthy males 

      Heitmann, Kim Arne; Dalen, Håvard; Gundersen, Guri Holmen; Ingvaldsen, Rolf Petter; Welde, Boye (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-07-29)
      This randomized within‐subjects crossover‐designed study evaluated intra‐arterial blood pressure (BP) traits in seven healthy males (24 ± 1 years) during heavy resistance exercise (HRE) to failure (10 × 5 repetitions, 5RES) and not to failure (10 × 3 repetitions, 3RES), both at 5RM load. By combining few repetitions, avoidance of Valsalva maneuver, and restricting the duration of each contraction, ...

    • Intrinsic coagulation pathway-mediated thrombin generation in mouse whole blood 

      Konrath, Sandra; Mailer, Reiner K.; Beerens, Manu; Englert, Hanna; Frye, Maike; Kuta, Piotr; Preston, Roger J. S.; Maas, Coen; Butler, Lynn; Roest, Mark; de Laat, Bas; Renné, Thomas (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-28)
      Calibrated Automated Thrombography (CAT) is a versatile and sensitive method for analyzing coagulation reactions culminating in thrombin generation (TG). Here, we present a CAT method for analyzing TG in murine whole blood by adapting the CAT assay used for measuring TG in human plasma. The diagnostically used artificial and physiologic factor XII (FXII) contact activators kaolin, ellagic acid ...

    • Introducing dental local anaesthesia using a standardized cognitive behavioural technique 

      Vestjord, Maria; Kjøløymo, Tina; Nerdal, Anne Marte (Master thesis; Mastergradsoppgave, 2012-05-29)
      A major dilemma is that pain free dental treatment using local anaesthesia (LA) is of main importance for avoiding dental fear and anxiety (DFA) at the same time as intraoral injections are strongly associated with DFA. Well-educated dentists and dental hygienists, with a variety of techniques and approaches available, are important to give the patient receiving LA a perception of control. The purpose ...

    • Introducing Lightweight IT – A Way to Build Flexibility for Healthcare Organizations? 

      Severinsen, Gro-Hilde; Silsand, Line; Malm-Nicolaisen, Kristian; Pedersen, Rune; Ellingsen, Gunnar (Journal article; Tidsskriftartikkel; Peer reviewed, 2022)
      The paper addresses socio technical relations of implementing a lightweight IT app in Norway. The focus is on how such technology will influence the possibilities for an organization connected to a large-scale heavyweight IT infrastructure to provide more rapid changes in line with healthcare worker’s needs. The research question is therefore: How can lightweight IT support rapid organizational ...

    • Introduction and rationale: An overview of refugee education Europe 

      Gunntorsdottir, Hermina; Douglas, Marcela; Saus, Merete; Paulgaard, Gry (Chapter; Bokkapittel, 2020)
      According to the UNHCR’s report Global Trends - Forced Displacement in 2018 (UNHCR, 2019) on changes in UNHCR’s population of concern related to ongoing crises, the number of refugees under UNHCR’s care is almost double that of 2012, with two thirds coming from just 5 countries. Furthermore it is stated that the total global refugee population under UNHCR’s mandate is now at the highest level ever ...

    • An introduction to network analysis for studies of medication use 

      Askar, Mohsen Gamal Saad; Nozal Cañadas, Rafael; Svendsen, Kristian (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-29)
      Background - Network Analysis (NA) is a method that has been used in various disciplines such as Social sciences and Ecology for decades. So far, NA has not been used extensively in studies of medication use. Only a handful of papers have used NA in Drug Prescription Networks (DPN). We provide an introduction to NA terminology alongside a guide to creating and extracting results from the medication ...

    • Introduction to the special issue: Homeostatic vs. Hedonic feeding. 

      McCutcheon, James Edgar; Williams, Diana (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-01)

    • Introduction: Sensations, Symptoms and Healthcare Seeking 

      Andersen, Rikke Sand; Nichter, Mark; Risør, Mette Bech (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-03)
      Inspired by the sensory turn in the humanities, anthropologists have coined the term ‘an anthropology of the senses’ to describe the study of the perceptual construction and output of bodily sensations and sense-modalities (cf. Howes 2006; Nichter 2008). Starting from the premise that different cultures and social settings configure, elaborate and extend the senses in different directions, key ...

    • Introduction: Training is more important than technology (for performance in the cold) 

      Friedl, Karl E.; Hasselstrom, Henriette; Kingma, Boris R.M.; Norheim, Arne Johan; Ojanen, Tommi; Sullivan-Kwantes, Wendy; Teien, Hilde Kristin; White, Graham (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-27)
      After more than 50 years of studying soldiers in the cold, we are well past the phase of defining the unique problems; the research requirements are known but the solutions have been slow in coming. This requires iterative testing of proposed lab-based solutions with soldiers in the real environment. Representing a renewed effort to produce and implement solutions to human biomedical challenges in ...