Blar i forfatter Det helsevitenskapelige fakultet "Ueland, Thor"

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    • Markers of extracellular matrix remodeling and systemic inflammation in patients with heritable thoracic aortic diseases 

      Seim, Bjørn Edvard; Holt, Margrethe Flesvig; Ratajska, Aleksandra; Michelsen, Annika Elisabet; Ringseth, Monica Myklebust; Halvorsen, Bente; Skjelland, Mona; Kvitting, John-Peder; Lundblad, Runar; Krohg-Sørensen, Kirsten; Osnes, Liv T. N.; Aukrust, Pål; Paus, Benedicte; Ueland, Thor (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-12-20)
      Background: In approximately 20% of patients with thoracic aortic aneurysms or dissections a heritable thoracic aortic disease (HTAD) is suspected. Several monogenic connective tissue diseases imply high risk of aortic disease, including both non-syndromic and syndromic forms. There are some studies assessing inflammation and extracellular matrix remodeling in patients with non-hereditary aortic ...

    • Monocyte/macrophage and T cell activation markers are not independently associated with MI risk in healthy individuals - results from the HUNT Study 

      Ueland, Thor; Laugsand, Lars Erik; Vatten, Lars Johan; Janszky, Imre; Platou, Carl Geoffrey Parrinder; Michelsen, Annika; Damås, Jan Kristian; Aukrust, Pål; Åsvold, Bjørn Olav (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-06-06)
      <p><i>Background</i>: We hypothesized that circulating markers reflecting monocyte/macrophage and T cell activation are associated with increased risk of myocardial infarction (MI) in apparently healthy individuals.</p> <p><i>Methods</i>: Serum monocyte/macrophage and T cell activation markers soluble (s) CD163, sCD14, Gal3BP, sCD25 and sCD166 were analyzed by enzyme-immunoassay in a case-control ...

    • Osteoprotegerin is associated with major bleeding but not with cardiovascular outcomes in patients with acute coronary syndromes: Insights from the PLATO (Platelet Inhibition and Patient Outcomes) trial 

      Ueland, Thor; Åkerblom, Axel; Ghukasyan, Tatevik; Michelsen, Annika; Aukrust, Pål; Becker, Richard C.; Bertilsson, Maria; Himmelmann, Anders; James, Stefan K.; Siegbahn, Agneta; Storey, Robert F.; Kontny, Frederic; Wallentin, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-01-12)
      Background: <br>Elevated levels of osteoprotegerin, a secreted tumor necrosis factor–related molecule, might be associated with adverse outcomes in patients with coronary artery disease. We measured plasma osteoprotegerin concentrations on hospital admission, at discharge, and at 1 and 6 months after discharge in a predefined subset (n=5135) of patients with acute coronary syndromes in the PLATO ...

    • Patients with depression display cytokine levels in serum and cerebrospinal fluid similar to patients with diffuse neurological symptoms without a defined diagnosis 

      Hestad, Knut A.; Engedal, Knut; Whist, Jon Elling; Aukrust, Pål; Farup, Per Grønaas; Mollnes, Tom Eirik; Ueland, Thor (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-04-13)
      INTRODUCTION: Several reports indicate that inflammation may play a role in depression and demonstrate enhanced systemic levels of inflammatory mediators. We hypothesized that 44 patients with a diagnosis of depression would present with a specific and different serum and cerebrospinal fluid (CSF) cytokine profile compared to 21 patients with diffuse neurological symptoms, of whom 15 had fatigue as ...

    • Persistent pulmonary pathology after COVID-19 is associated with high viral load, weak antibody response, and high levels of matrix metalloproteinase-9 

      Lerum, Tøri Vigeland; Maltzahn, Niklas; Aukrust, Pål; Trøseid, Marius; Nezvalova-Henriksen, Katerina; Kåsine, Trine; Dyrhol-Riise, Anne Ma; Stiksrud, Birgitte; Haugli, Mette; Blomberg, Bjørn; Kittang, Bård Reiakvam; Johannessen, Asgeir; Hannula, Raisa; Aballi, Saad; Kildal, Anders Benjamin; Eiken, Ragnhild; Dahl, Tuva Børresdatter; Lund-Johansen, Fridtjof; Müller, Fredrik; Rivero, Jezabel Rodriguez; Meltzer, Carin; Einvik, Gunnar; Ueland, Thor; Olsen, Inge Christoffer; Barratt-Due, Andreas; Aaløkken, Trond Mogens; Skjønsberg, Ole Henning (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-01)
      The association between pulmonary sequelae and markers of disease severity, as well as pro-fibrotic mediators, were studied in 108 patients 3 months after hospital admission for COVID-19. The COPD assessment test (CAT-score), spirometry, diffusion capacity of the lungs (DL<sub>CO</sub>), and chest-CT were performed at 23 Norwegian hospitals included in the NOR-SOLIDARITY trial, an open-labelled, ...

    • Plasma hepcidin is associated with future risk of venous thromboembolism 

      Ellingsen, Trygve; Lappegård, Jostein; Ueland, Thor; Aukrust, Pål; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2018)
      Red cell distribution width (RDW) is associated with venous thromboembolism (VTE), but the underlying mechanism(s) is unclear. Iron deficiency is associated with high RDW, and studies suggest an association between iron deficiency and VTE. To assess whether iron deficiency is a risk factor for VTE that explains the association between RDW and VTE, we conducted a nested case-control study of 390 ...

    • Plasma levels of growth differentiation factor 15 are associated with future risk of venous thromboembolism 

      Hansen, Ellen-Sofie; Hindberg, Kristian; Latysheva, Nadezhda; Aukrust, Pål; Ueland, Thor; Hansen, John-Bjarne; Brækkan, Sigrid Kufaas; Morelli, Vania Maris (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-15)
      Growth differentiation factor 15 (GDF-15), a marker of inflammation and oxidative stress, has emerged as a biomarker for arterial cardiovascular disease. However, the association between GDF-15 and venous thromboembolism (VTE) remains uncertain. We therefore investigated the association between plasma GDF-15 levels and future risk of incident VTE and explored the potential of a causal association ...

    • Plasma levels of leptin and risk of future incident venous thromboembolism 

      Frischmuth, Tobias; Hindberg, Kristian; Aukrust, Pål; Ueland, Thor; Brækkan, Sigrid K.; Hansen, John-Bjarne; Morelli, Vania Maris (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-11)
      Background - Circulating levels of leptin, an adipocyte-derived hormone, are frequently elevated in obesity. Leptin has been reported to upregulate prothrombotic hemostatic factors in vitro and could potentially mediate venous thromboembolism (VTE) risk in obesity. However, whether leptin is associated with VTE remains uncertain.<p> <p>Objective - This article investigates the association between ...

    • Plasma levels of mannose-binding lectin and future risk of venous thromboembolism 

      Liang, Robin Amanda; Høiland, Ina Isabella; Ueland, Thor; Aukrust, Pål; Snir, Omri; Hindberg, Kristian; Brækkan, Sigrid Kufaas; Garred, Peter; Mollnes, Tom Eirik; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-20)
      <i>Background</i> - Animal and observational studies have suggested a pathophysiological role for complement in venous thromboembolism (VTE), but the initiating mechanisms are unknown. Mannose‐binding lectin (MBL) bound to altered host cells leads to activation of the lectin complement pathway, and both high and low MBL levels have been implicated in the pathophysiology of cardiovascular ...

    • Plasma levels of P-selectin and future risk of incident venous thromboembolism 

      Swamy, Samantha; Ueland, Thor; Hansen, John Bjarne; Snir, Omri; Brækkan, Sigrid Kufaas (Journal article; Tidsskriftartikkel, 2023-05-12)
      Background - P-selectin levels are elevated following acute deep vein thrombosis and reported to predict recurrent venous thromboembolism (VTE) and cancer-associated VTE. Yet, it is unknown whether plasma P-selectin levels are associated with incident VTE.<p> <p>Objectives - We aimed to investigate the association between plasma P-selectin levels and risk of future incident VTE.<p> <p>Methods ...

    • Plasma levels of von Willebrand factor and future risk of incident venous thromboembolism 

      Edvardsen, Magnus; Hindberg, Kristian; Hansen, Ellen-Sofie; Morelli, Vania Maris; Ueland, Thor; Aukrust, Pål; Brækkan, Sigrid Kufaas; Holtet Evensen, Line; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-07)
      Several case-control studies have reported elevated plasma von Willebrand factor (VWF) levels in patients with venous thromboembolism (VTE) compared with controls. However, because few studies have investigated the association in a prospective design, it is unclear whether elevated plasma VWF is a risk factor or a consequence of the VTE event. Therefore, we aimed to investigate the prospective ...

    • Plasma lipopolysaccharide-binding protein is a biomarker for future venous thromboembolism: Results from discovery and validation studies 

      Jensen, Søren Beck; Latysheva, Nadezhda; Hindberg, Kristian; Ueland, Thor (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-04-14)
      Background<p> <p>Effect-size underestimation impedes biomarker identification. Long follow-up time in prospective studies attenuates effect-size estimates for transient biomarkers, while disease category–specific biomarkers are affected by merging of categories. Venous thromboembolism (VTE) encompasses deep vein thrombosis (DVT) and pulmonary embolism (PE). <p>Objectives <p>(i) To re-analyze untargeted ...

    • Plasma n-6 Polyunsaturated Fatty Acid Levels and Survival in Renal Transplantation 

      Skaare, Helga; Svensson, My Hanna Sofia; Jenssen, Trond Geir; Åsberg, Anders; Schmidt, Erik Berg; Chandra, Anupam; Ueland, Thor; Mollnes, Tom Eirik; Hartmann, Anders; Eide, Ivar Anders (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-04-24)
      <p><i>Objective</i>: The major n-6 polyunsaturated fatty acids linoleic acid (LA) and arachidonic acid (AA) play a role in inflammation and glucose metabolism, which could affect patient and renal transplant survival.</p> <p><i>Design and methods</i>: In this single center cohort study of 1988 Norwegian renal transplant recipients, we assessed associations between plasma levels of LA and AA at ...

    • Prediction of gestational diabetes mellitus and pre-diabetes 5 years postpartum using 75 g oral glucose tolerance test at 14-16 Weeks' gestation 

      Lekva, Tove; Godang, Kristin; Michelsen, Annika E.; Qvigstad, Elisabeth; Normann, Kjersti R.; Norwitz, Errol R.; Tore, Henriksen; Bollerslev, Jens; Roland, Marie; Ueland, Thor (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-09-06)
      Early detection and treatment of women at risk for gestational diabetes mellitus (GDM) could improve perinatal and long-term outcomes in GDM women and their offspring. We explored if a 75 g oral glucose tolerance test (OGTT) at 14-16 weeks of gestation could identify women who will (1) develop GDM or give birth to large-for-gestational-age (LGA) babies in 1031 pregnant women from the STORK study ...

    • Pro-gastrin-releasing peptide and outcome in patients with heart failure and anaemia: results from the RED-HF study 

      Ueland, Thor; Gullestad, Lars; Kou, Lei; Aukrust, Pål; Anand, Inder S.; Nordlund, Marianne Sparby; McMurray, John J.; van Veldhuisen, Dirk J.; Warren, David; Bolstad, Nils (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-08-25)
      <p><i>Aims</i>: Neuroendocrine activation is associated with poor outcome in heart failure (HF). The neuropeptide gastrin‐releasing peptide (GRP), derived from the precursor proGRP1‐125 (proGRP), has recently been implicated in inflammation and wound repair. We investigated the predictive value of proGRP on clinical outcomes in HF patients with reduced ejection fraction.</p> <p><i>Methods and ...

    • Prognostic biomarkers for immunotherapy with ipilimumab in metastatic melanoma 

      Nyakas, Marta Sølvi; Aamdal, Elin; Jacobsen, Kari Dolven; Guren, Tormod Kyrre; Aamdal, Steinar; Hagene, Kirsten Thorin; Brunsvig, Paal Fr.; Yndestad, Arne; Halvorsen, Bente; Tasken, Kristin Austlid; Aukrust, Pål; Mælandsmo, Gunhild Mari; Ueland, Thor (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-01)
      New therapies, including the anti‐cytotoxic T lymphocyte antigen (CTLA)‐4 antibody, ipilimumab, is approved for metastatic melanoma. Prognostic biomarkers need to be identified, because the treatment has serious side effects. Serum samples were obtained before and during treatment from 56 patients with metastatic or unresectable malignant melanoma, receiving treatment with ipilimumab in a national ...

    • Randomized Trial of Interleukin-6 Receptor Inhibition in Patients With Acute ST-Segment Elevation Myocardial Infarction 

      Broch, Kaspar; Anstensrud, Anne Kristine; Woxholt, Sindre; Sharma, Kapil Kishore; Tøllefsen, Ingvild Maria; Bendz, Bjørn; Aakhus, Svend; Ueland, Thor; Amundsen, Brage H.; Damås, Jan Kristian; Berg, Erlend; Bjørkelund, Elisabeth; Bendz, Christina; Hopp, Einar; Kleveland, Ola; Stensæth, Knut Haakon; Opdahl, Anders; Kløw, Nils-Einar; Seljeflot, Ingebjørg; Andersen, Geir Øystein; Wiseth, Rune; Aukrust, Pål; Gullestad, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-12)
      <p><i>Background - </i>Prompt myocardial revascularization with percutaneous coronary intervention (PCI) reduces infarct size and improves outcomes in patients with ST-segment elevation myocardial infarction (STEMI). However, as much as 50% of the loss of viable myocardium may be attributed to the reperfusion injury and the associated inflammatory response. <p><i>Objectives - </i>This study sought ...

    • Secreted frizzled related protein 3 in chronic heart failure: Analysis from the controlled rosuvastatin multinational trial in heart failure (CORONA) 

      Askevold, Erik Tandberg; Gullestad, Lars; Nymo, Ståle Haugset; Kjekshus, John; Yndestad, Arne; Latini, Roberto; Cleland, John G.F.; McMurray, John J.V.; Aukrust, Pål; Ueland, Thor (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-08-19)
      Background We have previously demonstrated an association between increased sFRP3 expression and adverse outcome in a population of HF irrespective of cause and left ventricular ejection fraction. In this study we evaluated the prognostic value of sFRP3 in older patients with chronic systolic HF of ischemic origin. <p>Methods We evaluated sFRP3, by tertiles, as a risk factor for the primary ...

    • Serum levels of inflammation-related markers and metabolites predict response to neoadjuvant chemotherapy with and without bevacizumab in breast cancers 

      Nome, Marianne Eikhom; Euceda, Leslie R.; Jabeen, Shakila; Debik, Julia; Bathen, Tone Frost; Giskeødegård, Guro F.; Tasken, Kristin Austlid; Mælandsmo, Gunhild Mari; Halvorsen, Bente; Yndestad, Arne; Borgen, Elin; Garred, Øystein; Aukrust, Pål; Ueland, Thor; Engebraaten, Olav; Kristensen, Vessela N.; Tekpli, Xavier (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-08-24)
      Angiogenesis is necessary for tumor growth and has been targeted in breast cancer; however, it is unclear which patients will respond and benefit from antiangiogenic therapy. We report noninvasive monitoring of patient response to neoadjuvant chemotherapy given alone or in combination with anti‐vascular endothelial growth factor (bevacizumab) in a randomized clinical trial. At four time points during ...

    • Serum Markers of Neuronal Damage and Astrocyte Activity in Patients with Chronic Epilepsy: Elevated Levels of Glial Fibrillary Acidic Protein 

      Mochol, Monika; Taubøll, Erik; Aukrust, Pål; Ueland, Thor; Andreassen, Ole; Svalheim, Sigrid (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-07)
      Objectives. Blood-brain barrier (BBB) dysfunction is one of the key pathogenic mechanisms in the development of epilepsy. There is therefore an increasing need to identify BBB biomarkers as these will have prognostic and therapeutic implications. The purpose of this study was to assess the levels of the BBB permeability markers, glial fibrillary acidic protein (GFAP), neuron-specific enolase ...