Viser treff 1117-1136 av 10152

    • C-X-C ligand 16 is an independent predictor of cardiovascular death and morbidity in acute coronary syndromes 

      Andersen, Thomas; Ueland, Thor; Ghukasyan Lakic, Tatevik; Åkerblom, Axel; Bertilsson, Maria; Aukrust, Pål; Michelsen, Annika E; James, Stefan K.; Becker, Richard C.; Storey, Robert F.; Wallentin, Lars; Siegbahn, Agneta; Kontny, Frederic (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-26)
      <i>Objective:</i> - The chemokine CXCL16 (C-X-C motif ligand 16) is a scavenger receptor for OxLDL (oxidized low-density lipoproteins) and involved in inflammation at sites of atherosclerosis. This study aimed to investigate the association of CXCL16 with clinical outcome in patients with acute coronary syndrome.<p> <p><i>Approach and Results:</i> - Serial measurements of CXCL16 were performed ...
    • C1 inhibitor deficiency enhances contact pathway–mediated activation of coagulation and venous thrombosis 

      Grover, Steven P.; Kawano, Tomohiro; Wan, Jun; Tanratana, Pansakorn; Polai, Zsofia; Shim, Young J.; Snir, Omri; Brækkan, Sigrid Kufaas; Dhrolia, Sophia; Kasthuri, Rohan R.; Bendapudi, Pavan K.; McCrae, Keith R.; Wolberg, Alisa S.; Hansen, John Bjarne; Farkas, Henriette; Mackman, Nigel (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-11)
      C1 inhibitor (C1INH) is a multifunctional serine protease inhibitor that functions as a major negative regulator of several biological pathways, including the contact pathway of blood coagulation. In humans, congenital C1INH deficiency results in a rare episodic bradykinin-mediated swelling disorder called hereditary angioedema (HAE). Patients with C1INH deficiency–associated HAE (C1INH-HAE) have ...
    • C1-inhibitor. Betydning i sykdom og terapi -Et narrativt litteraturstudium belyst med publikasjoner av T.E Mollnes, E.W. Nielsen og medarbeidere ved immunologisk forskningslaboratorium Nordlandssykehuset Bodø 

      Evjenth, Marie Hansen (Master thesis; Mastergradsoppgave, 2017-09-18)
      Formålet med denne oppgaven er todelt. Hoveddelen av oppgaven er et narrativt litteraturstudium med mål å få en bred og god forståelse for hvilken struktur og funksjon C1-inhibitor har, hvilken effekt proteinet har i de ulike kaskadesystemene i kroppen hvor proteinet inngår som en regulator, samt hvilken rolle proteinet spiller i patogenesen ved hereditært angioødem, alt dette belyst med publikasjoner ...
    • Cabazitaxel-loaded Poly(2-ethylbutyl cyanoacrylate) nanoparticles improve treatment efficacy in a patient derived breast cancer xenograft 

      Fusser, Markus; Øverbye, Anders; Pandya, Abhilash D.; Mørch, Ýrr Asbjørg; Borgos, Sven Even F.; Kildal, Wanja; Snipstad, Sofie; Sulheim, Einar; Fleten, Karianne Giller; Askautrud, Hanne Arenberg; Engebraaten, Olav; Flatmark, Kjersti; Iversen, Tore Geir; Sandvig, Kirsten; Skotland, Tore; Mælandsmo, Gunhild Mari (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-04)
      The effect of poly(2-ethyl-butyl cyanoacrylate) nanoparticles containing the cytotoxic drug cabazitaxel was studied in three breast cancer cell lines and one basal-like patient-derived xenograft model grown in the mammary fat pad of immunodeficient mice. Nanoparticle-encapsulated cabazitaxel had a much better efficacy than similar concentrations of free drug in the basal-like patient-derived xenograft ...
    • Cabin temperature during prehospital patient transport – a prospective observational study 

      Svendsen, Tuva; Lund-Kordahl, Inger; Fredriksen, Knut (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-13)
      <i>Background</i> - Few studies have investigated the patient compartment temperatures during ambulance missions or its relation to admission hypothermia. Still hypothermia is a known risk factor for increased mortality and morbidity in both trauma and disease. This has special relevance to our sub-arctic region’s pre-hospital services, and we prospectively studied the environmental temperature in ...
    • Cabin temperature during prehospital patient transport – a prospective observational study from Northern Norway 

      Svendsen, Tuva (Master thesis; Mastergradsoppgave, 2019-11-01)
      Background Few studies have investigated the patient compartment temperatures during ambulance missions or its relation to admission hypothermia. Still hypothermia is a known risk factor for increased mortality and morbidity in both trauma and disease. This has special relevance to our sub-arctic region’s pre-hospital services, and we prospectively studied the environmental temperature in the patient ...
    • Caesarean section rates and activity-based funding in Northern Norway: A model-based study using the World Health Organization's recommendation 

      Norum, Jan; Svee, Tove Elisabeth (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-07-16)
      <i>Objective</i>: Caesarean section (CS) rates vary significantly worldwide. ,e World Health Organization (WHO) has recommended a maximum CS rate of 15%. Norwegian hospitals are paid per CS (activity-based funding), employing the diagnosis-related group (DRG) system. We aimed to document how financial incentives can be affected by reduced CS rates, according to the WHO’s recommendation. <p> <p> ...
    • The Cafeteria Diet: a standardized protocol and its effects on behavior 

      Lalanza, Jaume F; Snoeren, Eelke (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-10)
      Obesity is a major health risk, with junk food consumption playing a central role in weight gain, because of its high palatability and high-energy nutrients. The Cafeteria (CAF) diet model for animal experiments consists of the same tasty but unhealthy food products that people eat (e.g. hot dogs and muffins), and considers variety, novelty and secondary food features, such as smell and texture. ...
    • Caffeine and primary (migraine) headaches-friend or foe? 

      Alstadhaug, Karl Bjørnar; Andreou, Anna P. (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-03)
      <i>Background</i>: The actions of caffeine as an antagonist of adenosine receptors have been extensively studied, and there is no doubt that both daily and sporadic dietary consumption of caffeine has substantial biological effects on the nervous system. Caffeine influences headaches, the migraine syndrome in particular, but how is unclear.<p> <p><i>Materials and Methods</i>: This is a narrative ...
    • Caffeine for treating apnea in premature babies - A literary review 

      Kristiansen, Christel Brekke (Master thesis; Mastergradsoppgave, 2021-05-31)
      Premature infants with pulmonary complications is becoming a substantial health care problem. Apnea of prematurity being one of the biggest challenges that may end in death with no or wrongful treatment. Non-invasive respiratory support has been the favorable alternative, and caffeine citrate has been the drug of choice since the 1970s. The aim of this study was to explore how effective caffeine is ...
    • Calanus oil and its lipid constituents - Impact on obesity and obesity-related metabolic disorders in rodents 

      Höper, Anje Christina (Doctoral thesis; Doktorgradsavhandling, 2014-02-26)
      Fedme er et økende helseproblem, og spesielt er avleiring av bukfett forbundet med økt risiko for en rekke sykdommer. Kosttilskudd med omega-3 fettsyrer har vist positive effekter på fedme-relaterte sykdommer. Calanusolje er et relativt nytt produkt som produseres fra raudåte (Calanus finmarchicus) som finnes i store mengder i norske farvann. Oljen har lavt innhold av miljøgifter og er rik på ...
    • Calcium Intake and Lung Cancer Risk: A Pooled Analysis of 12 Prospective Cohort Studies 

      Takata, Yumie; Yang, Jae Jeong; Yu, Danxia; Smith-Warner, Stephanie A.; Blot, William J.; White, Emily; Robien, Kimberly; Prizment, Anna; Wu, Kana; Sawada, Norie; Lan, Qing; Park, Yikyung; Gao, Yu-Tang; Cai, Qiuyin; Song, Mingyang; Zhang, Xuehong; Pan, Kathy; Agudo, Antonio; Panico, Salvatore; Liao, Linda M.; Tsugane, Shoichiro; Chlebowski, Rowan T.; Nøst, Therese Haugdahl; Schulze, Matthias B.; Johannson, Mattias; Zheng, Wei; Shu, Xiao-Ou (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-11)
      Background - Previous studies on calcium intake and lung cancer risk reported inconsistent associations, possibly due to the differences in intake amounts and contributing sources of calcium and smoking prevalence.<p> <p>Objectives - We investigated the associations of lung cancer risk with intake of calcium from foods and/or supplements and major calcium-rich foods in 12 studies.<p> <p>Methods ...
    • CALCOCO1 acts with VAMP ‐associated proteins to mediate ER ‐phagy 

      Nthiga, Thaddaeus Mutugi; Shrestha, Birendra Kumar; Sjøttem, Eva; Bruun, Jack-Ansgar; Larsen, Kenneth Bowitz; Bhujabal, Zambarlal; Lamark, Trond; Johansen, Terje (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-11)
      The endoplasmic reticulum (ER) plays important roles in protein synthesis and folding, and calcium storage. The volume of the ER and expression of its resident proteins are increased in response to nutrient stress. ER‐phagy, a selective form of autophagy, is involved in the degradation of the excess components of the ER to restore homeostasis. Six ER‐resident proteins have been identified as ER‐phagy ...
    • CALCOCO1 is a soluble reticulophagy receptor 

      Mutugi Nthiga, Thaddaeu; Shrestha, Birendra Kumar; Lamark, Trond; Johansen, Terje (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-25)
      The endoplasmic reticulum (ER) is the largest membrane-bound organelle in eukaryotic cells and plays critical roles in diverse processes in metabolism, signaling and intracellular organization. In response to stress stimuli such as nutrient deprivation, accumulation of misfolded proteins or exposure to chemicals, the ER increases in size through upregulated synthesis of its components to counteract ...
    • Calculating the 30-day survival in acute myocardial infarction: should we use the treatment chain or the hospital catchment model? 

      Norum, Jan; Hansen, Tonya Moen; Hovland, Anders; Balteskard, Lise; Haug, Bjørn; Olsen, Frank; Trovik, Thor (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-01-12)
      <p><i>Introduction</i> Acute myocardial infarction (AMI) is a potentially deadly disease and significant efforts have been concentrated on improving hospital performance. A 30-day survival rate has become a key quality of care indicator. In Northern Norway, some patients undergoing AMI are directly transferred to the Regional Cardiac Intervention Center at the University Hospital of North Norway ...
    • A Call for Urgent Monitoring of Food and Water Security Based on Relevant Indicators for the Arctic 

      Nilsson, Lena Maria; Destouni, Georgia; Berner, James; Dudarev, Alexy A.; Mulvad, Gert; Odland, Jon Øyvind; Parkinson, Alan; Tikhonov, Constantine; Rautio, Arja; Evengård, Birgitta (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      This perspective paper argues for an urgent need to monitor a set of 12 concrete, measurable indicators of food and water security in the Arctic over time. Such a quantitative indicator approach may be viewed as representing a reductionist rather than a holistic perspective, but is nevertheless necessary for actually knowing what reality aspects to monitor in order to accurately understand, quantify, ...
    • CAM in Europe - a complex legal and regulative situation. Will hamonized EU-wide regulation strengthen CAM research and practice? 

      Wiesener, Solveig; Fønnebø, Vinjar (Conference object; Konferansebidrag, 2011)
      <p><i>Background and objectives</i> The Pan-European research network CAMbrella was established under the 7th Framework Programme in 2010. One of the main aims is to review the legal and regulatory status for Complementary and Alternative Medicine, and indicate how legal and regulatory differences can be taken into account both in research initiatives and efforts to secure equal access to health ...
    • "CAMCrossEurope" regulation- Impact on patient safety- with focus on supervision 

      Wiesener, Solveig (Conference object; Konferansebidrag, 2015)
    • «CAMCrossEurope» regulation – with an osteopathy focus. Will harmonization improve patient safety? 

      Wiesener, Solveig (Conference object; Konferansebidrag, 2013)
    • «CAMCrossEurope» regulation. Impact on patient safety – with focus on India-Nor collaboration 

      Wiesener, Solveig (Conference object; Konferansebidrag, 2015)