Candida auris (C. auris) er en gjærsopp som kan forårsake alvorlige infeksjoner hos mennesker. Infeksjoner med Candida auris forekommer i hovedsak i helseinstitusjoner og rammer som regel alvorlig syke pasienter. I tillegg er behandling vanskelig fordi soppen ofte er resistent/motstandsdyktig mot de vanligste medikamentene som brukes ved Candida-infeksjon.

<i>Background</i>: With recent changes in legislation regulating recreational and medical cannabis use around the globe, increased use in pregnancy is to be expected.<p> <p><i>Objectives</i>: To investigate the association between cannabis use during pregnancy and birth outcomes. <p> <p><i>Method</i>: Data from the Norwegian Mother and Child Cohort Study (MoBa), a prospective pregnancy cohort, ...

Background - When capacity-based mental health legislation was introduced in Norway in 2017, there was concern about the consequences of change in the law for patients’carer whose community treatment order was revoked as a result of being assessed as having capacity to consent. The concern was that the lack of a community treatment order would increase carers’ responsibilities in an already challenging ...

<b><p>Aims</b> Antimicrobial resistance genes (ARGs) are often associated with mobile genetic elements (MGEs), which facilitate their movement within and between bacterial populations. Detection of mobility is therefore important to understand the dynamics of MGE dissemination and their associated genes, especially in resistant clinical isolates that often have multiple ARGs associated with MGEs. ...

Two novel bla_DIM-1- or bla<SUB>IMP-1</SUB>-containing genomic islands (GIs) were discovered by whole-genome sequence analyses in four extensively drug-resistant (XDR) <i>Pseudomonas aeruginosa</i> isolates from inpatients at a tertiary hospital in Ghana. The strains were of sequence type 234 (ST234) and formed a phylogenetic clade together with ST111, which is recognized as a global ...

The very positive effect of hydrogels on wounds and enhanced wound healing process has been proven. Hydrogels provide a warm, moist environment for wound that makes it heal faster in addition to their useful mucoadhesive properties. Moreover, hydrogels can be used as carriers for liposomes containing variety of drugs, such as antimicrobial drugs. This will provide a depot release of drug to the wound ...

Aims - Cisplatin-based chemotherapy (CBCT) is essential in the treatment of metastatic testicular cancer (TC) but has been associated with long-term risk of cardiovascular morbidity and mortality. Furthermore, cisplatin can be detected in the body decades after treatment. We aimed to evaluate the long-term impact of CBCT on cardiac function and morphology in TC survivors 30 years after treatment.< ...

Heart failure is associated with altered myocardial substrate utilization and reduced cardiac efficiency - changes that are hallmarks in heart failure independent of disease aetiology. This thesis describes remodelling in two distinct models of heart failure, namely obesity-mediated cardiomyopathy and early failure induced using a low dose angiotensin II (AngII). The reported cardiac phenotype in ...

The thesis consists of experimental studies elucidating the mechanisms that contribute to changes in cardiac efficiency by i) the increase in fatty acid supply to the heart (chronic and acute), ii) changes in cardiac calcium handling and iii) physical exercise. By measuring the heart's oxygen consumption for both mechanical and non-mechanical processes, we have shown for the first time, that oxygen-cost ...

This thesis springs from 3 different papers: Paper 1 A randomised controlled study in rats to investigate whether an infusion of crystalloids or colloids during rewarming from hypothermia could alleviate the alterations in cardiovascular function seen in untreated control animals. Paper 2 A randomised controlled study in pigs, examining normothermic vs hypothermic cardiopulmonary resuscitation (CPR). ...