The SRY-related HMG box gene 10 (SOX10), located on 22q13.1, encodes a member of the SOX family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate and differentiation. SOX10 is one of the six causal genes for Waardenburg syndrome, which is a dominantly inherited auditory-pigmentary disorder characterized by sensorineural hearing impairment ...

Objective: To retrospectively evaluate empress crowns/onlays placed in patients treated by dentistry students at the University clinic in Tromsø. Material and methods: A total of 37 empress restorations placed in 26 patients were evaluated according to the California Dental Association´s (CDA) quality evaluation system. All of the reconstructions were luted with resin composite cement. The mean ...

Clinical reasoning is a core activity in everyday clinical work, but is also a well-developed field of research with scholarly papers, reviews, books, conferences and medical curriculum activities. In this body of knowledge, and although it remains a complex construct [1], clinical reasoning is generally defined as the cognitive processes and mental structures that physicians mobilise to decide on ...

Noncommunicable diseases are among the most significant health threats in our society, being cardiovascular diseases (CVD) the most prevalent. Because of the severity and prevalence of these illnesses, early detection and prevention are critical for reducing the worldwide health and economic burden. Though machine learning (ML) methods usually outperform conventional approaches in many domains, class ...

<p><i>Background</i>: Earlier work has described videoconferencing technologies, peripheral equipment, organizational models, human relations, purposes, goals and roles as versatile, multifaceted, and those used differently in different clinical practices. Knowledge about benefits and challenges connected to specific characteristics of services are lacking. A 2005 systematic review of published ...

Neuroblastoma is a pediatric cancer of the developing sympathetic nervous system. High-risk neuroblastoma patients typically undergo an initial remission in response to treatment, followed by recurrence of aggressive tumors that have become refractory to further treatment. The need for biomarkers that can select patients not responding well to therapy in an early phase is therefore needed. In this ...

This qualitative study explores Sami and non-Sami clinicians’ assumptions about Sami culture and their experiences in providing mental health services to Sami patients. The aim is to better understand and improve the ways in which culture is incorporated into mental health services in practice. Semi-structured interviews were conducted with 20 clinicians in mental health outpatient clinics in the ...

Denne studien har undersøkt Escherichia coli resistente for kinoloner, en bredpektret gruppe antibiotika. Målet har vært å finne ut hvorfor disse bakteriene oftere er resistente mot andre antoibiotikagrupper. Studiet er basert på molekylærgenetisk analyser - herunder klonal analyse, plasmidanalyser og undersøkelse av resistensgener. Resultatene viser at kinolonresistente Escherichia coli er ofte ...

Chronic myelogenous leukaemia is a monoclonal hematopoetic stem cell disorder characterised by the t(9;22) translocation and results in the constitutively activated Bcr-Abl tyrosine kinase. Since the tyrosine kinase activity of the Bcr-Abl fusion protein is the causative molecular event in CML, targeting the tyrosine kinase activity appears to be an attractive therapeutic strategy. Imatinib, ...