Great advances in molecular biology, genetics and imaging serve to enhance the desire to develop multi-level and multi-scale models for "personalized medicine" but they remain very challenging for high prevalence, high impact childhood onset neuropsychiatric disorders. We currently have the capacity to develop innovative, effective and efficient clinical decision support models, while also creating ...

<i>Background</i> - Randomised trials on antibiotic treatment for patients with chronic low back pain and vertebral endplate changes visible on MRI (Modic changes) have shown mixed results. A possible explanation might be a real treatment effect in subgroups of the study populations. The purpose of the present study was to explore potential clinical effect modifiers of 3-months oral amoxicillin ...

<i>Introduction</i> - Diarrhea-predominant irritable bowel syndrome (IBS-D) is a gastrointestinal disease with a high incidence and no effective drugs available. Compound Glutamine Entersoluble Capsules (CGEC) is a compound preparation integrating Sijunzi Decoction and L-Glutamine. The aim of this systematic review was to evaluate the clinical effects and safety of CGEC for IBS-D.<p> <p><i>Methods</i> ...

Systemisk Lupus Erythematosus (SLE) er en kronisk sykdom der immunforsvaret produserer antistoffer som kan angripe kroppens egne organer. I 1997 ble klassifikasjonskriteriene for å stille diagnosen endret slik at flere typer autoantistoffer ble inkludert. For å undersøke mulige endringer etter innføring av de nye 1997 klassifikasjonskriteriene for SLE, delte vi inn pasientene i to grupper. En ...

Introduction: Identifying predictors of bacterial and viral pathogens in sputum from patients with acute exacerbations of chronic obstructive pulmonary disease (COPD) may help direct management.<p> <p>Methods: We used data from a trial evaluating a C-reactive protein (CRP) point of care guided approach to managing COPD exacerbations in primary care. We used regression analyses to identify ...

Object - Although many patients report clinical improvement after surgery due to degenerative cervical myelopathy, the aim of intervention is to stop progression of spinal cord dysfunction. We wanted to provide estimates and assess achievement rates of Minimal Clinically Important Difference (MCID) at 3- and 12-month follow-up for Neck Disability Index (NDI), Numeric Rating Scale for arm pain (NRS-AP) ...

Vitamin D is vital for calcium homeostasis and skeletal health, has immunomodulatory effects and is involved in the regulation of differentiation and proliferation of many different cell types. Adipose tissue is an important metabolic organ and a major organ for vitamin D storage. Though, the role of vitamin D and its function in adipose tissue is not fully explored. This thesis applies a solvent ...

The SRY-related HMG box gene 10 (SOX10), located on 22q13.1, encodes a member of the SOX family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate and differentiation. SOX10 is one of the six causal genes for Waardenburg syndrome, which is a dominantly inherited auditory-pigmentary disorder characterized by sensorineural hearing impairment ...

Objective: To retrospectively evaluate empress crowns/onlays placed in patients treated by dentistry students at the University clinic in Tromsø. Material and methods: A total of 37 empress restorations placed in 26 patients were evaluated according to the California Dental Association´s (CDA) quality evaluation system. All of the reconstructions were luted with resin composite cement. The mean ...