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    • Collaboration between Sami and non-Sami formal and family caregivers in rural municipalities 

      Larsen, Lill Sverresdatter; Normann, Hans Ketil; Hamran, Torunn (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-09-17)
      The aim of this study was to explore how caregivers experience collaboration in rural municipalities in northern Norway. We conducted fieldwork with a dementia team in addition to seventeen qualitative in-depth interviews with formal and family caregivers. The caregivers had ethnic Sami and ethnic Norwegian affiliation. The theme ‘negotiating ethnic and ethno-political positions’ was identified ...

    • Collagen-covered autologous chondrocyte implantation versus autologous matrix-induced chondrogenesis: A randomized trial comparing 2 methods for repair of cartilage defects of the knee 

      Fossum, Vegard; Hansen, Ann Kristin; Wilsgaard, Tom; Knutsen, Gunnar (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-17)
      <i>Background</i>: Autologous matrix-induced chondrogenesis (AMIC) is a single-stage alternative to autologous chondrocyte implantation for treatment of localized cartilage defects of the knee. To our knowledge, no randomized controlled trial exists comparing the 2 methods.<p><p> <i>Purpose</i>: To evaluate any difference in the outcome of AMIC as compared with collagen-covered autologous chondrocyte ...

    • Collateral Sensitivity and Resistance Networks in Clinical Escherichia coli Isolates 

      Norvik, Mari (Master thesis; Mastergradsoppgave, 2015-05-13)
      Because of an increasing development of antimicrobial resistance, treatment options for bacterial infectious diseases are narrowed. A strategy to reduce the evolution of resistance is to take advantage of antimicrobial collateral networks. In this thesis, we explored these collateral networks with a focus on antimicrobials used in Norway for the treatment of cystitis. Cystitis is the most common ...

    • Collateral sensitivity in clinical Escherichia coli isolates 

      Nguyen, Lilli Minh (Master thesis; Mastergradsoppgave, 2015-05-13)
      The continuous increase in resistance development towards antimicrobial agents is a well-known problem, however, insecurities exist about how frequently the emergence of resistance in microbes, at the same time, leads to an increased sensitivity to other antimicrobial agents. This phenomenon is called “collateral sensitivity”. We evolved resistance in clinical E. coli strains towards three antimicrobial ...

    • Collateral sensitivity in clinical Escherichia coli isolates 

      Tran, Jessica Nguyen (Master thesis; Mastergradsoppgave, 2018-05-15)
      <p><i>Background</i> At present time, antimicrobial resistance is emerging more rapidly than the development of novel antimicrobials, presenting a serious threat to how we prevent and treat infectious diseases. Several treatment strategies to counteract this development have been proposed, among these is the use of collateral sensitivity in clinical treatment. The ability to predict collateral ...

    • Collateral sensitivity in clinical Escherichia coli isolates resistant to ciprofloxacin 

      Lam, Chon Kit (Master thesis; Mastergradsoppgave, 2016-05-13)
      The increase in antimicrobial resistance in bacteria is a serious problem in public heath limiting the efficacy of available antimicrobials for treatment of infections. E. coli is the most frequent cause of uncomplicated urinary tract infections. Ciprofloxacin is an important antimicrobial for treatment of uncomplicated urinary tract infections. Unfortunately, resistance to ciprofloxacin is commonly ...

    • Collateral sensitivity in clinical Escherichia coli isolates resistant to ciprofloxacin and/or mecillinam 

      Hasund, Camilla Remøy (Master thesis; Mastergradsoppgave, 2017-05-16)
      The escalating emergence of AMR is a growing public health concern, and a result of the use and misuse of antibiotics since its introduction. To prevent the development of resistance and preserve the efficacy of antimicrobial agents, new treatment strategies is of utmost importance. One possible approach may be to take advantage of collateral sensitivity, a phenomenon where bacteria acquiring ...

    • Collateral sensitivity in clinical Escherichia coli isolates resistant to ciprofloxacin and/or mecillinam 

      Hasund, Camilla Remøy (Master thesis; Mastergradsoppgave, 2017-05-16)
      The escalating emergence of AMR is a growing public health concern, and a result of the use and misuse of antibiotics since its introduction. To prevent the development of resistance and preserve the efficacy of antimicrobial agents, new treatment strategies is of utmost importance. One possible approach may be to take advantage of collateral sensitivity, a phenomenon where bacteria acquiring ...

    • Collateral sensitivity in clinical mecillinam resistant isolates of Escherichia coli 

      Nguyen, Tammy Tam Hoai Thi (Master thesis; Mastergradsoppgave, 2016-05-13)
      Background The rapid increase in antimicrobial resistance (AMR) has become a major threat to the successful management of infectious diseases. To counteract this global threat, development of novel treatment strategies is essential. A promising strategy may be exploiting collateral sensitivity; a phenomenon that occurs when a microorganism that has developed resistance to one antimicrobial agent, ...

    • Coloring of the past via respondent’s current psychological state, mediation, and the association between childhood disadvantage and morbidity in adulthood 

      Sheikh, Mashhood Ahmed (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-05-31)
      <p><i>Objective</i>: Many researchers view retrospective reports with skepticism. Indeed, the observed association between retrospectively-reported childhood disadvantage (CD) and morbidity in adulthood has been criticized as an artefactual correlation driven by the psychological state of the respondent at the time of reporting (current psychological state). The aim of this study was to assess the ...

    • Colostrum og akutt påvirkning av serum IGF-1 : et pilotprosjekt for å vurdere utslag på framtidige dopingtester 

      Trulsen, Lene Nymo; Øverøyen, Anne Weber (Master thesis; Mastergradsoppgave, 2010-09-15)
      Misbruk av veksthormon er mest aktuelt i idretter som krever styrke og lav fettprosent. Deteksjon av veksthormonbruk blant idrettsutøvere gjøres med et isoform ratio immunoassay utviklet for å skille mellom forholdet av veksthormonisoformer sett ved normale fysiologiske forhold, og de sett etter injeksjon av rekombinant veksthormon. Insulinlignende vekstfaktor-1 (IGF-1) medierer mange av veksthormons ...

    • Coma influence on manifest astigmatism in coma-dominant irregular corneal optics 

      Zhou, Wen; Stojanovic, Filip; Reinstein, Dan Z.; Archer, Timothy J.; Chen, Xiangjun; Feng, Yue; Stojanovic, Aleksandar (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-01)
      PURPOSE:To evaluate the influence of coma on manifest refractive cylinder (MRC) in eyes with coma-dominated corneal optics and suggest alternative guidelines for surgical planning of astigmatism correction in topography-guided ablation and toric intraocular lens (IOL) exchange surgery.<p> <p>METHODS:Twelve eyes with coma-dominant corneal optics and low lenticular astigmatism were selected. The ...

    • Combating antibiotic resistance: An approach to discover antimicrobial compounds 

      Wigand, Johannes; Winje, Endre (Mastergradsoppgave; Master thesis, 2022-05-01)
      Objective: This study aims to test a cost-effective approach for discovery of novel molecular compounds with antimicrobial characteristics. Materials and methods: Thirteen randomly picked objects were swabbed in the area in and around Liverpool. They were further cultivated on BHI-agar plates, and then spread on top of several clinically relevant pathogenic indicator strains including C. albicans, ...

    • A combination of infraclavicular and suprascapular nerve blocks for total shoulder arthroplasty: A case series 

      Musso, Dario Davide; Klaastad, Øivind; Ytrebø, Lars Marius (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-27)
      Background - Shoulder arthroplasty is associated with significant post-operative pain. Interscalene plexus block is the gold standard for pain management in patients undergoing this surgery, however, alternatives are currently being developed. We hypothesized that a combination of anterior suprascapular nerve block and lateral sagittal infraclavicular block would provide effective post-operative ...

    • A combined effect of anti-HPA-1a and anti-HLA Class I in pregnancy? 

      Dahl, Jesper; Skogen, Bjørn; Kjær, Mette; Husebekk, Anne; Kjeldsen-Kragh, Jens; Tiller, Heidi (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-30)
      <i>Background</i> - Maternal anti–human leukocyte antigen (HLA) Class I is commonly detected alongside anti–human platelet antigen (HPA)-1a in fetal and neonatal alloimmune thrombocytopenia (FNAIT). Little is known regarding whether the presence of anti-HLA Class I may exert an additive effect on the risk and severity of FNAIT.<br><br> <i>Methods and Materials</i> - We reanalyzed samples originally ...

    • Combined effect of high factor VIII levels and high mean platelet volume on the risk of future incident venous thromboembolism 

      Hansen, Ellen-Sofie; Edvardsen, Magnus; Aukrust, Pål; Ueland, Thor; Hansen, John Bjarne; Brækkan, Sigrid Kufaas; Morelli, Vania Maris (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-29)
      Background - High factor VIII (FVIII) levels and large platelets, as reflected by a high mean platelet volume (MPV), are separately associated with increased risk of venous thromboembolism (VTE). Whether the combination of high FVIII levels and large platelets has a supra-additive effect on VTE risk is unknown.<p> <p>Objectives - We aimed to investigate the joint effect of high FVIII levels and ...

    • Combined effects of cancer and prothrombotic genotypes on the risk of venous thromboembolism 

      Skille, Hanne (Doctoral thesis; Doktorgradsavhandling, 2021-06-18)
      Venous thromboembolism (VTE), a collective term for deep vein thrombosis and pulmonary embolism, is a severe and multifactorial disease. Heritability has been found to explain up to 60% of VTE events, however, the role of genetics on VTE in cancer is scarcely studied. VTE occurs frequently in cancer patients and is a common cause of morbidity and mortality in this patient group. The aim of the present ...

    • Combined effects of five prothrombotic genotypes and cancer on the risk of a first venous thromboembolic event 

      Skille, Hanne; Paulsen, Benedikte; Hveem, Kristian; Gabrielsen, Maiken Elvestad; Brumpton, Ben Michael; Hindberg, Kristian; Gran, Olga Vikhammer; Rosendaal, Frits Richard; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-16)
      Background - The role of combined prothrombotic genotypes in cancer‐related venous thromboembolism (VTE) is scarcely studied. We aimed to investigate the impact of a 5‐single nucleotide polymorphism (SNP) score on the risk of VTE in patients with and without cancer using a population‐based case‐cohort.<p> <p>Methods - Cases with a first VTE (n = 1493) and a subcohort (n = 13 072) were derived ...

    • Combined effects of plasma von Willebrand factor and platelet measures on the risk of incident venous thromboembolism 

      Edvardsen, Magnus; Hansen, Ellen-Sofie; Hindberg, Kristian; Morelli, Vania Maris; Ueland, Thor; Aukrust, Pål; Brækkan, Sigrid Kufaas; Holtet Evensen, Line; Hansen, John Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-23)
      Plasma von Willebrand factor (VWF) and platelet reactivity are risk factors for venous thromboembolism (VTE), and VWF can promote hemostasis by interaction with platelets. In this study, we explored the combined effects of plasma VWF and platelet measures on the risk of incident VTE. A population-based nested case-control study with 403 cases and 816 controls was derived from the Tromsø Study. VWF, ...

    • A combined experimental-computational approach uncovers a role for the Golgi matrix protein Giantin in breast cancer progression 

      Ghannoum, Salim; Fantini, Damiano; Zahoor, Muhammad; Reiterer, Veronika; Phuyal, Santosh; Leoncio Netto, Waldir; Sørensen, Øystein; Iyer, Arvind; Sengupta, Debarka; Prasmickaite, Lina; Mælandsmo, Gunhild Mari; Kohn Luque, Alvaro; Farhan, Hesso (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-17)
      Our understanding of how speed and persistence of cell migration affects the growth rate and size of tumors remains incomplete. To address this, we developed a mathematical model wherein cells migrate in two-dimensional space, divide, die or intravasate into the vasculature. Exploring a wide range of speed and persistence combinations, we find that tumor growth positively correlates with increasing ...